Effect of heat stress on LPS-induced fever and tumor necrosis factor.
Am J Physiol
; 273(3 Pt 2): R858-63, 1997 Sep.
Article
em En
| MEDLINE
| ID: mdl-9321860
ABSTRACT
Exposure to heat stress leads to both short-term and long-term effects on morbidity. Male rats were exposed to a high ambient temperature of 40 degrees C, which resulted in biotelemetered core body temperature rising to approximately 42 degrees C. This treatment led to a marked enhancement in lipopolysaccharide (LPS)-induced fever at 24 h after exposure to heat stress. The increase in fever was accompanied by a significant suppression in the circulating concentration of tumor necrosis factor. Heat-shock protein-70 measured in liver was elevated by the heat exposure (but not further elevated by the injection of LPS). An enhanced fever to LPS and other inflammatory stimuli found in heat-stressed human subjects could explain the apparent increase in susceptibility to disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Contexto em Saúde:
3_ND
Problema de saúde:
3_neglected_diseases
/
3_zoonosis
Assunto principal:
Estresse Fisiológico
/
Regulação da Temperatura Corporal
/
Lipopolissacarídeos
/
Fator de Necrose Tumoral alfa
/
Febre
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Am J Physiol
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos