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Effect of heat stress on LPS-induced fever and tumor necrosis factor.
Kluger, M J; Rudolph, K; Soszynski, D; Conn, C A; Leon, L R; Kozak, W; Wallen, E S; Moseley, P L.
Afiliação
  • Kluger MJ; Lovelace Respiratory Research Institute, Albuquerque 87108, USA.
Am J Physiol ; 273(3 Pt 2): R858-63, 1997 Sep.
Article em En | MEDLINE | ID: mdl-9321860
ABSTRACT
Exposure to heat stress leads to both short-term and long-term effects on morbidity. Male rats were exposed to a high ambient temperature of 40 degrees C, which resulted in biotelemetered core body temperature rising to approximately 42 degrees C. This treatment led to a marked enhancement in lipopolysaccharide (LPS)-induced fever at 24 h after exposure to heat stress. The increase in fever was accompanied by a significant suppression in the circulating concentration of tumor necrosis factor. Heat-shock protein-70 measured in liver was elevated by the heat exposure (but not further elevated by the injection of LPS). An enhanced fever to LPS and other inflammatory stimuli found in heat-stressed human subjects could explain the apparent increase in susceptibility to disease.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 3_ND Problema de saúde: 3_neglected_diseases / 3_zoonosis Assunto principal: Estresse Fisiológico / Regulação da Temperatura Corporal / Lipopolissacarídeos / Fator de Necrose Tumoral alfa / Febre Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Am J Physiol Ano de publicação: 1997 Tipo de documento: Article País de afiliação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Contexto em Saúde: 3_ND Problema de saúde: 3_neglected_diseases / 3_zoonosis Assunto principal: Estresse Fisiológico / Regulação da Temperatura Corporal / Lipopolissacarídeos / Fator de Necrose Tumoral alfa / Febre Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Am J Physiol Ano de publicação: 1997 Tipo de documento: Article País de afiliação: Estados Unidos
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