Transmembrane grasshopper Semaphorin I promotes axon outgrowth in vivo.
Development
; 124(18): 3597-607, 1997 Sep.
Article
em En
| MEDLINE
| ID: mdl-9342052
ABSTRACT
Members of the Semaphorin family of glycoproteins play an important role in axonal pathfinding by functioning as inhibitory guidance cues. Here we provide evidence that a transmembrane form of Semaphorin (Semaphorin I), which is expressed by bands of epithelial cells in the developing grasshopper limb bud, functions as an attractive/permissive cue for the growth cones of the subgenual organ. In addition, we demonstrate that Semaphorin I is needed for initial axonal outgrowth from the subgenual organ. These results are consistent with an alternative function for a transmembrane form of Semaphorin and may explain the previously reported arrest of the proximal extension of the subgenual organ growth cones in the absence of the Ti1 pioneer pathway.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Axônios
/
Moléculas de Adesão Celular Neuronais
/
Botões de Extremidades
/
Semaforinas
/
Gafanhotos
Limite:
Animals
Idioma:
En
Revista:
Development
Assunto da revista:
BIOLOGIA
/
EMBRIOLOGIA
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Canadá