The expression in vivo of a second isoform of pT alpha: implications for the mechanism of pT alpha action.
J Immunol
; 161(1): 11-6, 1998 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-9647201
ABSTRACT
A second isoform of pT alpha, "pT alpha(b)," is derived from the pT alpha locus by tissue-specific, alternative splicing. pT alpha(b) is coexpressed in the thymus with the previously characterized form of pT alpha (which we term pT alpha(a)) and is also expressed in peripheral cells without pT alpha(a). While pT alpha(a) acts to retain most TCR beta-chains intracellularly, pT alpha(b) permits higher levels of cell surface TCR beta expression and facilitates signaling from a CD3-TCR beta complex.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Membrana
/
Receptores de Antígenos de Linfócitos T alfa-beta
Limite:
Animals
Idioma:
En
Revista:
J Immunol
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos