Myelodysplastic syndrome after regression of transient abnormal myelopoiesis in a Down syndrome infant: different clonal origin?
Cancer Genet Cytogenet
; 104(2): 115-8, 1998 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-9666804
ABSTRACT
A boy with Down syndrome who developed myelodysplastic syndrome after regression of transient abnormal myelopoiesis (TAM) is described. His blast cells in TAM had other chromosome abnormalities in addition to trisomy 21;50,XY,+21c,+12,+14,+21. Serial chromosome analysis in follow-up showed abnormal clones involving monosomy 7. Myelodysplastic syndrome was diagnosed. Because two clones had different karyotypes, they might have derived from different clones.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndromes Mielodisplásicas
/
Aberrações Cromossômicas
/
Síndrome de Down
/
Leucopoese
Limite:
Humans
/
Male
/
Newborn
Idioma:
En
Revista:
Cancer Genet Cytogenet
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Japão