Effectiveness of a 2-Week Strength Training Learning Intervention on Self-selected Weight-Training Intensity.

Glass, SC, Ahmad, S, and Gabler, T. Effectiveness of a 2-week strength training learning intervention on self-selected weight-training intensity. J Strength Cond Res 34(9): 2443-2448, 2020-The purpose of this study was to determine the effectiveness of an imposed (IM) vs. self-selected (SS) 2-week strength training intervention on SS resistance training intensity. Subjects 18-40 years (SS n = 10 and IM n = 10) were provided resistance training orientation (chest press, leg press, triceps extension, bicep curl, and shoulder press). On 6 different training days, subjects completed 2 sets on each machine while blinded to the load. The SS group SS loads without any intensity or effort feedback. Load, repetitions, and ratings of perceived exertion (RPE) were recorded. The IM group was encouraged to lift to fatigue, and if they exceeded 12 repetitions, subsequent load was increased (goal-attain 70% one repetition maximum [1RM]). After training, SS and IM SS loads and repetitions for all lifts, plus 3 novel lifts (pec fly, leg extension, and shoulder raise). One repetition maximum was assessed last. Comparisons between groups were made using 2-way analysis of variance. There were significant main effects for % 1RM for the condition and day (day 1 IM = 57.2 ± 12.0%, SS = 47.2 ± 13.7% and day 6 IM = 74.7 ± 10.8%, SS = 66.2 ± 13.4%). There were significant effects across days for reps (day 1 IM = 10.8 ± 4.8, SS = 12.3 ± 4.0 and day 6 IM = 9.3 ± 3.6, SS = 10.0 ± 3.0) and RPE (day 1 = 15.4 ± 2.0 and day 6 = 16.5 ± 1.9). For both SS and IM post-training SS loads exceeded 60% 1RM. However, among the novel lifts, only the pec fly was greater than 60% 1RM (pec fly 63.0 ± 11.0%, leg extension 39.8 ± 12.5%, and shoulder raise 53.1 ± 12.8%). Two weeks of supervised resistance training resulted in both IM and SS self-selecting loads greater than 60% 1RM. There were no differences after 2-weeks of training between IM load and SS load groups.

Tumour lysis syndrome: implications for cancer therapy.

The tumour lysis syndrome (TLS) is a group of metabolic abnormalities caused by rapid and unexpected release of cellular components into the circulation as a result of massive destruction of rapidly proliferating malignant cells. It usually develops in patients with hematologic malignancies like acute lymphoid leukemia, non-Hodgkin and Burkitt's lymphoma after initiation of chemotherapy or may, rarely, occur spontaneously. Though TLS is seldom observed in relation to solid tumours, there have been reports of connections with examples such as lung, liver, breast, gastric carcinomas. The clinical manifestations of TLS include hyperuricemia, hyperkalemia, hyperphosphatemia and hypocalcemia. These indications if untreated lead to life-threatening complications such as acute renal failure, cardiac arrhythmias, seizures, and eventually death due to multiorgan failure. Therefore early detection of TLS is of vital importance. This can be accomplished by identification of high risk patients, implementation of suitable prophylactic measures and monitoring of the electrolyte levels in patients undergoing chemotherapy.

Chemoprotective and immunomodulatory effect of Acacia nilotica during cyclophosphamide induced toxicity.

Most of the synthetic chemotherapeutic agents used today are immunosuppressant and lead to numerous side effects. Plant based immunomodulators are employed as supportive therapy to counteract the undesirable side effects of chemotherapy. In the present study, the immunomodulatory and chemoprotective effect of methanolic extract of Acacia nilotica was investigated in mice. Intraperitoneal administration of the extract was found to significantly increase the Total WBC count, bone marrow cellularity and alpha-esterase positive cells. Cyclophosphamide is a chemotherapeutic drug and induces acute myelosuppression but treatment with the extract was beneficial in ameliorating chemically induced toxicity. The administration of the extract considerably increased the Total WBC count (6800 +/- 733.9 cells/cm2), bone marrow cellularity (43.6 x 10(5) +/- 14.33 cells/femur) and alpha-esterase positive cells (808.6 +/- 8.57 cells/4000 cells) in CTX treated mice when compared to CTX alone treated control mice. Weight of lymphoid organs such as spleen and thymus reduced by CTX were enhanced by treatment with Acacia nilotica extract. It can be concluded that the extract possess immunostimulatory properties.