Experiencias docentes en el cambio curricular vivido en la carrera de enfermería de la FES, Iztacala / Teaching experiences in the curricular change experienced in the nursing career of the FES Iztacala

Introducción: la calidad educativa en las IES (Instituciones de Educación Superior) ha sido avalada por procesos de evaluación y acreditación a nivel institucional y curricular, llevando a cabo un proceso de mejora continua, mediante recomendaciones sugeridas por los evaluadores, lo anterior garantizará la calidad institucional ante la formación de futuros profesionales. Objetivo: analizar las experiencias del profesorado de la carrera de enfermería de la Facultad de Estudios Superiores Iztacala, sobre el cambio curricular vivido. Material y métodos: estudio cualitativo con enfoque fenomenológico, mediante entrevista a profundidad a doce profesores de enfermería. Muestreo por conveniencia de acuerdo a la saturación de datos. En aspectos éticos y legales, se realizó carta de consentimiento informado. El análisis de datos fue basado en Miles y Huberman, con abordaje teórico según Van Manen. Resultados: surgieron dos categorías: 1. Sentimientos y afectaciones emocionales respecto al cambio curricular y laborales; 2. impacto del cambio curricular en los aprendizajes de los estudiantes, las cuales evidenciaron cómo el profesorado ha vivido los cambios curriculares en los 17 años desde que fue implementada la licenciatura. Conclusiones: los informantes narraron que en cada cambio curricular surgen emociones diferentes, entre incertidumbre, compromiso, responsabilidad y asumir empoderamiento para implementar la curricula, con ello, lograr los objetivos esperados por la misma, considerando perfil de egreso y rendimiento académico de los estudiantes.

Introduction: the educational quality at the higher level in schools and faculties has been endorsed by evaluation and accreditation processes at the institutional and curricular level, carrying out an improvement process, through the recommendations suggested by the evaluators, thus covering them in a certain time. The foregoing will guarantee the institutional quality before the training of future professionals. Objective: to analyze experiences of the teaching staff of the nursing career of the Iztacala Faculty of Higher Studies, on the curricular change experienced. Material and methods: Qualitative study with a phenomenological approach, through an in-depth interview with twelve nursing professors. Convenience sampling according to data saturation. In ethical and legal aspects, an informed consent letter was drawn up. The data analysis was through Miles and Huberman, with a theoretical approach based on Van Manen. Results: two categories emerged: 1. Feelings and emotional affectations regarding the curricular and work change; 2. impact of curricular change on student learning, which showed how teachers have experienced curricular changes in the 17 years since the degree was implemented. Conclusions: the informants narrated that in each curricular change different emotions arise, between uncertainty, commitment, responsibility and assuming empowerment to implement the curriculum, thereby achieving the objectives expected by it, considering the graduation profile and the academic performance of the students.

Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research.

Neuroactive steroids are endogenous neuromodulators synthesised in the brain that rapidly alter neuronal excitability by binding to membrane receptors, in addition to the regulation of gene expression via intracellular steroid receptors. Neuroactive steroids induce potent anxiolytic, antidepressant, anticonvulsant, sedative, analgesic and amnesic effects, mainly through interaction with the GABAA receptor. They also exert neuroprotective, neurotrophic and antiapoptotic effects in several animal models of neurodegenerative diseases. Neuroactive steroids regulate many physiological functions, such as the stress response, puberty, the ovarian cycle, pregnancy and reward. Their levels are altered in several neuropsychiatric and neurological diseases and both preclinical and clinical studies emphasise a therapeutic potential of neuroactive steroids for these diseases, whereby symptomatology ameliorates upon restoration of neuroactive steroid concentrations. However, direct administration of neuroactive steroids has several challenges, including pharmacokinetics, low bioavailability, addiction potential, safety and tolerability, which limit its therapeutic use. Therefore, modulation of neurosteroidogenesis to restore the altered endogenous neuroactive steroid tone may represent a better therapeutic approach. This review summarises recent approaches that target the neuroactive steroid biosynthetic pathway at different levels aiming to promote neurosteroidogenesis. These include modulation of neurosteroidogenesis through ligands of the translocator protein 18 kDa and the pregnane xenobiotic receptor, as well as targeting of specific neurosteroidogenic enzymes such as 17ß-hydroxysteroid dehydrogenase type 10 or P450 side chain cleavage. Enhanced neurosteroidogenesis through these targets may be beneficial not only for neurodegenerative diseases, such as Alzheimer's disease and age-related dementia, but also for neuropsychiatric diseases, including alcohol use disorders.

Perfil de ingreso de los alumnos de Enfermería, Facultades de Estudios Superiores Iztacala y Zaragoza, UNAM / Nursing student's enrollment profile, Iztacala and Zaragoza Superior Studies Faculties, UNAM

Introducción: La Universidad tiene como una de sus tareas conocer a los estudiantes, ya que en la medida que nuestro sistema de educación logre tener mayor información sobre el perfil de éstos y sus trayectorias escolares, se podrán diseñar e implementar políticas novedosas y funcionales que atiendan las necesidades específicas de su población. Objetivo: Analizar el perfil de los estudiantes que ingresan a la Licenciatura en Enfermería de México. Las Facultades de Estudios Superiores (FES) Iztacala y Zaragoza. Método: Estudio descriptivo-transversal, con estudiantes de primer ingreso de la generación 2011-I de la FES Zaragoza e Iztacala. La población de estudio fueron 600 alumnos. La recolección de la información fue a través de un cuestionario. La confiabilidad del instrumento fue de 0.875 con la prueba de Alfa de Cronbach. Para el manejo de la información se elaboró una base de datos con el programa SPSS® y se utilizó estadística descriptiva. Resultados: El 49% de alumnos proviene de pase reglamentado, el promedio de ingreso es de 8.1 a 9.0; en el 61% Enfermería fue primera elección; el nivel socioeconómico de los alumnos es bajo; en el 74% el promedio durante el primer año fue de 8.0 a 10.0. Discusión: A diferencia de otras Carreras de la Universidad Nacional Autónoma de México (UNAM), la de Enfermería da cabida a casi el 50% de los aspirantes de escuelas externas a ella. Los alumnos aún cuando son de nivel socioeconómico bajo, reúnen características favorables para su trayectoria escolar, entre ellas, un buen promedio y que fueron admitidos en la Carrera que seleccionaron.

Introduction: The University has as one of its tasks to better know the profiles and trajectories of students, so that supporting innovative and functional policies can be designed and implemented. Objective: To analyze the profile of students enrolling into the Nursing Undergraduate System at the Iztacala and Zaragoza Superior Studies Faculty. Method: Basic-descriptive study with freshmen students of the 2011-I generation of the Nursing Bachelors Degree program at the FES Zaragoza and Iztacala. the population was 600 alumni. A questionnaire was used to gather data. the instrument reliability was equivalent to a 0.875 Cronbach Alpha score. A SPSS® database was created and data were analyzed through descriptive statistics. Results: The 49% of the students came from the "automatic pass" format. The enrollment grade point average went from 8.1 to 9.0. For the 61% of the students, nursing was their first choice of major. The socioeconomic level of the students was low. The 76% of the students obtained a grade point average between 8.0 and 10.0 during all their freshman year. Discussion: Unlike other careers at the Universidad Nacional Autónoma de México (UNAM), Nursing accepts almost 50% of the prospects from external schools, situation which does not occur in other careers. Although the majority of students who entered have a low social-economical level, they have other favorable characteristics for their school trajectory such as a good grade point average and that they were accepted in the career that they chose.

Effect of chronic hCG administration on Alzheimer's-related cognition and A beta accumulation in PS1KI mice.

Age-associated changes in the reproductive hormones-the gonadal steroid hormones and the gonadotropins-have been identified as potential risk factors for Alzheimer's disease (AD). However, levels of gonadotropins and estrogens are closely linked in vivo, and it has proven difficult to separate the effects of gonadotropins from the well-documented estrogenic effects on AD-related neuropathology in experimental models of menopause. To assess the effects of gonadotropins on cognition and AD biochemical markers independent of estrogenic effects, a potent analog of luteinizing hormone [human chorionic gonadotropin (hCG)] was administered to ovariectomized presenilin1 knock-in mice (PS1KI). Gonadotropin administration was found to induce hyperactivity and anxiety (Open Field Maze and Taste Neophobia Task) and working memory dysfunction, without altering reference memory (Morris Water Maze). Although gonadotropin administration modestly altered ß amyloid (Aß40) levels, levels of the longer more toxic form (Aß42) were unaffected. Furthermore, altered Aß40 levels were not associated with observed behavioral and cognitive impairments. These findings provide proof, in principle, that the gonadotropin hormones play a role in the modulation of AD-related behavior, cognition, and neuropathology.

Ovariectomy and 17beta-estradiol replacement do not alter beta-amyloid levels in sheep brain.

The benefits of estrogen replacement as a preventative treatment for Alzheimer's disease (AD) are subject to debate. Because the effects of estrogen depletion and replacement on accumulation of the neurotoxic beta-amyloid (A beta) peptide in transgenic animal models of AD have been variable, we examined A beta levels and oxidative stress in a nontransgenic animal model. Sheep have traditionally been used as a model for human reproduction; however because they share 100% sequence homology with the human form of A beta, they may also have potential as a nontransgenic model for A beta biology. The effect of ovariectomy and estrogen replacement administered for 6 months via slow-release implant was examined in the brain of 4.5-yr-old sheep. A beta levels were measured by ELISA, and protein levels of the amyloid precursor protein (APP), APP C-terminal fragments (C100), and presenilin-1 were examined semiquantitatively by Western blot as markers of APP processing. Markers of oxidative stress were examined semiquantitatively by Western blot [4-hydroxy-2(E)-nonenal] and oxyblot (protein carbonyls). We found no effects of estrogen depletion and supplementation in terms of AD-related biochemical markers, including A beta levels, APP processing, and oxidative stress levels. Evidence of a trend toward increased P450 side-chain cleavage enzyme levels in the hippocampus of ovariectomized and estrogen supplemented sheep suggests that neurosteroidogenesis may compensate for gonadal estrogen depletion; however, these findings cannot explain the lack of effect of estrogen supplementation on APP processing. It is possible that supraphysiological doses of estrogen are necessary to yield antiamyloidogenic and antioxidative benefits in ovariectomized sheep.

Legislation, policy, and tobacco use among youth: implications for health care providers.

This paper addresses implications of recent tobacco legislation, policy, and tobacco use among youth in the context of health care policy and services. Tobacco use prevalence and definitions and diagnoses of nicotine addiction and dependence are described. Assessment of smoking prevalence in Texas provides a case study of the problem and potential solutions for tobacco use among youth. The case study highlights specific implications to be considered when providing health care focused on prevention and risk reduction for youth. The paper concludes with implications and critical Internet resources for health care providers engaging in youth tobacco control.

Robustness of bioequivalence procedures under Box-Cox alternatives.

This study investigates the robustness of Schuirmann's two one-sided tests procedure under a set of Box-Cox alternatives. A simulation is conducted to study the level of significance and the power of the procedure. Empirical results show that Schuirmann's procedure is robust under Box-Cox alternatives when the mean of the underlying distribution of the reference formulation is known, which suggests that the assumptions of normality or lognormality are sufficient but may not be necessary. It appears that Schuirmann's procedure cannot maintain the proper level of significance when the mean of the reference formulation is unknown, even under the normality or lognormality assumptions.

Heterotopic pancreas: gastric outlet obstruction secondary to pancreatitis and pancreatic pseudocyst.

Heterotopic pancreas, usually a silent gastrointestinal anomaly, may become clinically evident when complicated by a pathologic process. We report a unique case in which pancreatitis and pseudocyst formation in an antral lesion produced gastric outlet obstruction. The nature of heterotopic pancreas, its diagnosis, and management are discussed.