ABSTRACT
We performed comparative analysis of hemodynamic in the periodontal microcirculatory bed in adolescents with arterial hypertension (AH) and morphological changes in the periodontal tissues of in hypertensive ISIAH rats of comparable biological age. In the periodontal tissues of adolescents with hypertension, the blood flow velocity and index of peripheral resistance increased, while pulse pressure decreased. In ISIAH rats, the mean area of periodontal and pulp vessels increased and the area of the connective tissue decreased. These results can be used in the complex assessment of morphofunctional state periodontium during hypertension development.
Subject(s)
Hypertension/physiopathology , Microcirculation , Periodontium/physiopathology , Adolescent , Animals , Blood Flow Velocity , Blood Pressure , Case-Control Studies , Female , Humans , Hypertension/diagnostic imaging , Male , Periodontium/blood supply , Periodontium/diagnostic imaging , Rats , Rats, Inbred SHR , Rats, Wistar , Ultrasonography, Doppler , Vascular ResistanceABSTRACT
The peculiarities of the histological structure and morphometrical parameters of the dentition in ISIAH rats (inherited stress-induced arterial hypertension) before stress and after modeling of everyday life stress regimen (chronic stress) were compared with those in WAG rats. The area of blood vessels of the periodontium, the thickness of the endothelium in the periodontal and pulp vessels, and the number of fibroblasts were increased, while the level of odontoblasts was reduced in ISIAH rats both before and after exposure to chronic stress, which can reflect more pronounced reaction to stress in hypertensive animals.
Subject(s)
Dentition , Hypertension/pathology , Periodontium/pathology , Stress, Physiological/physiology , Animals , Blood Pressure/physiology , Male , RatsABSTRACT
It was shown that the intensity of morphological changes in the dental system tissues (periodontium and pulp) of ISIAH rats depends on the mode of stress exposure. Acute stress was associated with a significant increase in the area of periodontal and pulp vessels, a decrease in the area of connective tissue of these components, and an increase in the thickness of the vascular endothelium. Chronic stress in these animals induced an increase in the thickness of the endothelial layer of the periodontal and pulp vessels, fibromatosis (increase in the number of fibroblasts), and a sharp decrease in the level of odontoblasts.