ABSTRACT
Professor R.V. Babakhanyan - Head of the Department of Forensic Medicine and Law, Pavlov First Saint Petersburg State Medical University is one of the notable teachers and scientists among the St. Petersburg forensic experts. Author of 500 published works, co-author of 6 monographs. He trained 28 candidates of medical sciences. The range of scientific interests - topical issues of forensic toxicology and injuries from non-lethal self-defense weapons.
Subject(s)
Forensic Medicine , Forensic Toxicology , History, 20th Century , Humans , MaleABSTRACT
Experiments on albino outbred rats showed that chronic poisoning with organophosphorus compounds (Russian VX, and sarin) for 30 days in a total dose of 0.3 DL50 (0.01 DL50 daily) is followed by a decrease in phagocytic and metabolic activity of neutrophils. The reduction of functional activity of monocyte phagocytic system was stipulated by the stimulation of N-cholinergic receptors of these cells. These changes were accompanied by a decrease in blood concentration of proinflammatory cytokines (TNF-α, IL-1ß, and IL-6).
Subject(s)
Cholinesterase Inhibitors/toxicity , Cytokines/metabolism , Neutrophils/physiology , Organothiophosphorus Compounds/toxicity , Phagocytosis/drug effects , Sarin/toxicity , Animals , Animals, Outbred Strains , Female , Inflammation Mediators , Lethal Dose 50 , Male , Neutrophils/drug effects , Nicotine/toxicity , Nicotinic Agonists/toxicity , RatsABSTRACT
The article is devoted to the 80th anniversary of the formation of the naval medical science subunit, which is the part of the 1st Central Research Institute of the Defense Ministry of Russian Federation. In the 30th years of XX century, a group of naval doctors formulated the main directions of preventive naval medicine. For eight decades, several generations of medical scientists have developed and ensured implementation of regulatory requirements for habitability and ergonomics of Navy ships. At the present stage, this work focuses on promising directions of the development of the domestic military shipbuilding and the use of advanced and innovative biomedical technologies.