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1.
Phys Rev Lett ; 132(12): 122701, 2024 Mar 22.
Article in English | MEDLINE | ID: mdl-38579210

ABSTRACT

^{140}Ce(n,γ) is a key reaction for slow neutron-capture (s-process) nucleosynthesis due to being a bottleneck in the reaction flow. For this reason, it was measured with high accuracy (uncertainty ≈5%) at the n_TOF facility, with an unprecedented combination of a high purity sample and low neutron-sensitivity detectors. The measured Maxwellian averaged cross section is up to 40% higher than previously accepted values. Stellar model calculations indicate a reduction around 20% of the s-process contribution to the Galactic cerium abundance and smaller sizeable differences for most of the heavier elements. No variations are found in the nucleosynthesis from massive stars.

2.
Phys Rev Lett ; 131(3): 031802, 2023 Jul 21.
Article in English | MEDLINE | ID: mdl-37540851

ABSTRACT

We report the direct observation of muon neutrino interactions with the SND@LHC detector at the Large Hadron Collider. A dataset of proton-proton collisions at sqrt[s]=13.6 TeV collected by SND@LHC in 2022 is used, corresponding to an integrated luminosity of 36.8 fb^{-1}. The search is based on information from the active electronic components of the SND@LHC detector, which covers the pseudorapidity region of 7.2<η<8.4, inaccessible to the other experiments at the collider. Muon neutrino candidates are identified through their charged-current interaction topology, with a track propagating through the entire length of the muon detector. After selection cuts, 8 ν_{µ} interaction candidate events remain with an estimated background of 0.086 events, yielding a significance of about 7 standard deviations for the observed ν_{µ} signal.

3.
Eur Phys J A Hadron Nucl ; 58(12): 239, 2022.
Article in English | MEDLINE | ID: mdl-36514540

ABSTRACT

Neutron capture reaction cross sections on 74 Ge are of importance to determine 74 Ge production during the astrophysical slow neutron capture process. We present new resonance data on 74 Ge( n , γ ) reactions below 70 keV neutron energy. We calculate Maxwellian averaged cross sections, combining our data below 70 keV with evaluated cross sections at higher neutron energies. Our stellar cross sections are in agreement with a previous activation measurement performed at Forschungszentrum Karlsruhe by Marganiec et al., once their data has been re-normalised to account for an update in the reference cross section used in that experiment.

4.
Phys Rev Lett ; 125(14): 142701, 2020 Oct 02.
Article in English | MEDLINE | ID: mdl-33064503

ABSTRACT

The neutron capture cross sections of several unstable nuclides acting as branching points in the s process are crucial for stellar nucleosynthesis studies. The unstable ^{171}Tm (t_{1/2}=1.92 yr) is part of the branching around mass A∼170 but its neutron capture cross section as a function of the neutron energy is not known to date. In this work, following the production for the first time of more than 5 mg of ^{171}Tm at the high-flux reactor Institut Laue-Langevin in France, a sample was produced at the Paul Scherrer Institute in Switzerland. Two complementary experiments were carried out at the neutron time-of-flight facility (n_TOF) at CERN in Switzerland and at the SARAF liquid lithium target facility at Soreq Nuclear Research Center in Israel by time of flight and activation, respectively. The result of the time-of-flight experiment consists of the first ever set of resonance parameters and the corresponding average resonance parameters, allowing us to make an estimation of the Maxwellian-averaged cross sections (MACS) by extrapolation. The activation measurement provides a direct and more precise measurement of the MACS at 30 keV: 384(40) mb, with which the estimation from the n_TOF data agree at the limit of 1 standard deviation. This value is 2.6 times lower than the JEFF-3.3 and ENDF/B-VIII evaluations, 25% lower than that of the Bao et al. compilation, and 1.6 times larger than the value recommended in the KADoNiS (v1) database, based on the only previous experiment. Our result affects the nucleosynthesis at the A∼170 branching, namely, the ^{171}Yb abundance increases in the material lost by asymptotic giant branch stars, providing a better match to the available pre-solar SiC grain measurements compared to the calculations based on the current JEFF-3.3 model-based evaluation.

5.
Eur J Paediatr Dent ; 20(4): 320-324, 2019 Dec.
Article in English | MEDLINE | ID: mdl-31850777

ABSTRACT

AIM: Local anaesthesia injection necessary for pain control in paediatric dentistry may itself be painful sometimes, partly because of the pressure felt during injection; electronically assisted injection systems were developed to address this problem. MATERIALS AND METHODS: Study design: The present study is a clinical study in children that compared two types of devices for paediatric buccal infiltration anaesthesia: the aspirating syringe and an electronically assisted injection system, the Wand STA. A split mouth, randomised controlled clinical trial was conducted on 30 healthy six to eight-year-old patients (6.64 ± 0.803 years) requiring pulpotomies on two symmetrical primary maxillary molars. Each patient received the following types of anaesthesia, in separate, consecutive, randomly ordered sessions: conventional buccal infiltration by metallic aspirating syringe and buccal infiltration by computer-controlled local anaesthetic device (Single Tooth Anesthesia). Parameters assessed were: pain experienced during injection, patient's heart rate and behaviour, anaesthesia quantity required and onset time. RESULTS: No statistical differences were observed between the two techniques (p? 0.05) for all assessed parameters. CONCLUSIONS: Results suggest that computer-assisted anaesthesia may represent an alternative to conventional syringes for local buccal anaesthesia in paediatric dental treatment; comparison to other types of dental infiltration anaesthesia needs further investigation.


Subject(s)
Anesthesia, Dental , Syringes , Anesthesia, Local , Anesthetics, Local , Child , Humans , Pain Measurement
6.
Phys Rev Lett ; 121(4): 042701, 2018 Jul 27.
Article in English | MEDLINE | ID: mdl-30095928

ABSTRACT

We report on the measurement of the ^{7}Be(n,p)^{7}Li cross section from thermal to approximately 325 keV neutron energy, performed in the high-flux experimental area (EAR2) of the n_TOF facility at CERN. This reaction plays a key role in the lithium yield of the big bang nucleosynthesis (BBN) for standard cosmology. The only two previous time-of-flight measurements performed on this reaction did not cover the energy window of interest for BBN, and they showed a large discrepancy between each other. The measurement was performed with a Si telescope and a high-purity sample produced by implantation of a ^{7}Be ion beam at the ISOLDE facility at CERN. While a significantly higher cross section is found at low energy, relative to current evaluations, in the region of BBN interest, the present results are consistent with the values inferred from the time-reversal ^{7}Li(p,n)^{7}Be reaction, thus yielding only a relatively minor improvement on the so-called cosmological lithium problem. The relevance of these results on the near-threshold neutron production in the p+^{7}Li reaction is also discussed.

7.
Eur Phys J C Part Fields ; 78(6): 505, 2018.
Article in English | MEDLINE | ID: mdl-30956555

ABSTRACT

Inelastic nuclear interaction probability of 400 GeV/c protons interacting with bent silicon crystals was investigated, in particular for both types of crystals installed at the CERN Large Hadron Collider for beam collimation purposes. In comparison to amorphous scattering interaction, in planar channeling this probability is ∼ 36 % for the quasi-mosaic type (planes (111)), and ∼ 27 % for the strip type (planes (110)). Moreover, the absolute inelastic nuclear interaction probability in the axial channeling orientation, along the ⟨ 110 ⟩ axis, was estimated for the first time, finding a value of 0.6 % for a crystal 2 mm long along the beam direction, with a bending angle of 55 µ rad. This value is more than two times lower with respect to the planar channeling orientation of the same crystal, and increases with the vertical angular misalignment. Finally, the correlation between the inelastic nuclear interaction probability in the planar channeling and the silicon crystal curvature is reported.

8.
Phys Med Biol ; 62(16): 6784-6803, 2017 Aug 01.
Article in English | MEDLINE | ID: mdl-28762335

ABSTRACT

In the field of particle therapy helium ion beams could offer an alternative for radiotherapy treatments, owing to their interesting physical and biological properties intermediate between protons and carbon ions. We present in this work the comparisons and validations of the Monte Carlo FLUKA code against in-depth dosimetric measurements acquired at the Heidelberg Ion Beam Therapy Center (HIT). Depth dose distributions in water with and without ripple filter, lateral profiles at different depths in water and a spread-out Bragg peak were investigated. After experimentally-driven tuning of the less known initial beam characteristics in vacuum (beam lateral size and momentum spread) and simulation parameters (water ionization potential), comparisons of depth dose distributions were performed between simulations and measurements, which showed overall good agreement with range differences below 0.1 mm and dose-weighted average dose-differences below 2.3% throughout the entire energy range. Comparisons of lateral dose profiles showed differences in full-width-half-maximum lower than 0.7 mm. Measurements of the spread-out Bragg peak indicated differences with simulations below 1% in the high dose regions and 3% in all other regions, with a range difference less than 0.5 mm. Despite the promising results, some discrepancies between simulations and measurements were observed, particularly at high energies. These differences were attributed to an underestimation of dose contributions from secondary particles at large angles, as seen in a triple Gaussian parametrization of the lateral profiles along the depth. However, the results allowed us to validate FLUKA simulations against measurements, confirming its suitability for 4He ion beam modeling in preparation of clinical establishment at HIT. Future activities building on this work will include treatment plan comparisons using validated biological models between proton and helium ions, either within a Monte Carlo treatment planning engine based on the same FLUKA code, or an independent analytical planning system fed with a validated database of inputs calculated with FLUKA.


Subject(s)
Helium/therapeutic use , Monte Carlo Method , Radiometry , Radiotherapy Planning, Computer-Assisted , Carbon/therapeutic use , Humans , Normal Distribution , Proton Therapy , Radiotherapy Dosage , Water
9.
Br Dent J ; 222(6): 467-471, 2017 Mar 24.
Article in English | MEDLINE | ID: mdl-28337015

ABSTRACT

Objectives The aim of this study was to evaluate the patients' willingness to pay (WTP) values and preference for the treatment of a tooth with very poor prognosis, among two options: root canal therapy and crown positioning or tooth extraction, implant insertion and crown positioning.Methods A total of 103 patients were recruited from a private dental clinic and interviewed. A questionnaire measured individuals' preferences among the two alternative treatments for a tooth with poor prognosis and the maximum amount of money they would be willing to pay for their choice with a starting bid of [euro]2,000 in [euro]100 increment/decrement. Demographic data, patient choice, median values and WTP association with socio-demographic factors (Student ttest and one-way ANOVA) and correlation between variables (Pearson chi-square test) were revealed.Results Seventy-six percent of patients expressed a preference for root canal therapy, while the remaining 24% chose the dental surgery. A fair agreement between previous experience and current therapeutic choice was found (P = 0.0001). The WTP median value was [euro]2,000 and 46% of participants would pay an additional sum of money for the therapy (median: [euro]300). The preferred treatment was influenced by previous experience, but no association was found between WTP values and socio-demographic factors.Conclusion Patients tend to prefer a conservative approach for the treatment of a tooth with poor prognosis and are willing to pay an additional fee to receive their treatment choice.


Subject(s)
Crowns , Dental Implantation , Patient Preference/economics , Root Canal Therapy , Tooth Extraction , Adult , Aged , Female , Humans , Male , Middle Aged , Patient Acceptance of Health Care , Self Report , Young Adult
10.
Diabet Med ; 34(5): 621-624, 2017 05.
Article in English | MEDLINE | ID: mdl-27885706

ABSTRACT

AIMS: Insulin pump failure and/or malfunction requiring replacement have not been thoroughly investigated. This study evaluated pump replacement in children and adolescents with Type 1 diabetes using insulin pump therapy. METHODS: Data were collected for all participants younger than 19 years, starting insulin pump therapy before 31 December 2013. For each child, age, disease duration, date of insulin pump therapy initiation, insulin pump model, failure/malfunction/replacement yes/no and reason were considered for the year 2013. RESULTS: Data were returned by 40 of 43 paediatric centres belonging to the Diabetes Study Group of the Italian Society of Paediatric Endocrinology and Diabetology. In total, 1574 of 11 311 (13.9%) children and adolescents with Type 1 diabetes were using an insulin pump: 29.2% Animas VIBE™ , 9.4% Medtronic MiniMed 715/515™ , 34.3% Medtronic MiniMed VEO™ , 24.3% Accu-Check Spirit Combo™ and 2.8% other models. In 2013, 0.165 insulin pump replacements per patient-year (11.8% due to pump failure/malfunction and 4.7% due to accidental damage) were recorded. Animas VIBE™ (22.1%) and Medtronic MiniMed VEO™ (17.7%) were the most replaced. CONCLUSIONS: In a large cohort of Italian children and adolescents with Type 1 diabetes, insulin pump failure/malfunction and consequent replacement are aligned with rates previously reported and higher in more sophisticated pump models.


Subject(s)
Diabetes Mellitus, Type 1/drug therapy , Equipment Failure/statistics & numerical data , Insulin Infusion Systems , Insulin/administration & dosage , Adolescent , Blood Glucose/analysis , Blood Glucose/drug effects , Blood Glucose Self-Monitoring/instrumentation , Child , Child, Preschool , Diabetes Mellitus, Type 1/blood , Diabetes Mellitus, Type 1/epidemiology , Female , Humans , Infant , Italy/epidemiology , Male , Retrospective Studies
11.
Phys Rev Lett ; 117(15): 152701, 2016 Oct 07.
Article in English | MEDLINE | ID: mdl-27768364

ABSTRACT

The energy-dependent cross section of the ^{7}Be(n,α)^{4}He reaction, of interest for the so-called cosmological lithium problem in big bang nucleosynthesis, has been measured for the first time from 10 meV to 10 keV neutron energy. The challenges posed by the short half-life of ^{7}Be and by the low reaction cross section have been overcome at n_TOF thanks to an unprecedented combination of the extremely high luminosity and good resolution of the neutron beam in the new experimental area (EAR2) of the n_TOF facility at CERN, the availability of a sufficient amount of chemically pure ^{7}Be, and a specifically designed experimental setup. Coincidences between the two alpha particles have been recorded in two Si-^{7}Be-Si arrays placed directly in the neutron beam. The present results are consistent, at thermal neutron energy, with the only previous measurement performed in the 1960s at a nuclear reactor. The energy dependence reported here clearly indicates the inadequacy of the cross section estimates currently used in BBN calculations. Although new measurements at higher neutron energy may still be needed, the n_TOF results hint at a minor role of this reaction in BBN, leaving the long-standing cosmological lithium problem unsolved.

12.
Phys Med Biol ; 61(11): 4283-99, 2016 06 07.
Article in English | MEDLINE | ID: mdl-27203864

ABSTRACT

Treatment planning studies on the biological effect of raster-scanned helium ion beams should be performed, together with their experimental verification, before their clinical application at the Heidelberg Ion Beam Therapy Center (HIT). For this purpose, we introduce a novel calculation approach based on integrating data-driven biological models in our Monte Carlo treatment planning (MCTP) tool. Dealing with a mixed radiation field, the biological effect of the primary (4)He ion beams, of the secondary (3)He and (4)He (Z = 2) fragments and of the produced protons, deuterons and tritons (Z = 1) has to be taken into account. A spread-out Bragg peak (SOBP) in water, representative of a clinically-relevant scenario, has been biologically optimized with the MCTP and then delivered at HIT. Predictions of cell survival and RBE for a tumor cell line, characterized by [Formula: see text] Gy, have been successfully compared against measured clonogenic survival data. The mean absolute survival variation ([Formula: see text]) between model predictions and experimental data was 5.3% ± 0.9%. A sensitivity study, i.e. quantifying the variation of the estimations for the studied plan as a function of the applied phenomenological modelling approach, has been performed. The feasibility of a simpler biological modelling based on dose-averaged LET (linear energy transfer) has been tested. Moreover, comparisons with biophysical models such as the local effect model (LEM) and the repair-misrepair-fixation (RMF) model were performed. [Formula: see text] values for the LEM and the RMF model were, respectively, 4.5% ± 0.8% and 5.8% ± 1.1%. The satisfactorily agreement found in this work for the studied SOBP, representative of clinically-relevant scenario, suggests that the introduced approach could be applied for an accurate estimation of the biological effect for helium ion radiotherapy.


Subject(s)
Helium/therapeutic use , Radioisotopes/therapeutic use , Radiotherapy Planning, Computer-Assisted/methods , Algorithms , Cell Line, Tumor , Cell Survival/radiation effects , Humans , Relative Biological Effectiveness
13.
Eur J Paediatr Dent ; 16(4): 290-4, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26637252

ABSTRACT

BACKGROUND: When treating children, a conservative and minimally invasive approach is mandatory. In dental traumas with partial coronal destruction, veneers represent the fastest and most effective method to rehabilitate front teeth of a young patient, since these no- or minimal-preparation restorations were proved to have predictable results without reducing the enamel layer. Indirect additive anterior composite restorations, besides being quick and minimally invasive, have to be considered a good treatment option for rehabilitating children, because they are inexpensive and repairable over time. Current laboratory techniques, associated with a strict clinical protocol, satisfy patients' restorative and aesthetic needs in few appointments and in a short time. CASE REPORT: The cases reported describe the minimally invasive treatment of two lateral incisors with nano-hybrid resin composite veneers after traumatic events. The patient satisfaction and good integration of indirect restorations confirmed the success of this rehabilitation.


Subject(s)
Composite Resins , Dental Veneers , Tooth Injuries/rehabilitation , Child , Dental Impression Technique , Humans , Male
14.
Phys Med Biol ; 60(5): 1845-63, 2015 Mar 07.
Article in English | MEDLINE | ID: mdl-25658644

ABSTRACT

Compton Cameras emerged as an alternative for real-time dose monitoring techniques for Particle Therapy (PT), based on the detection of prompt-gammas. As a consequence of the Compton scattering process, the gamma origin point can be restricted onto the surface of a cone (Compton cone). Through image reconstruction techniques, the distribution of the gamma emitters can be estimated, using cone-surfaces backprojections of the Compton cones through the image space, along with more sophisticated statistical methods to improve the image quality. To calculate the Compton cone required for image reconstruction, either two interactions, the last being photoelectric absorption, or three scatter interactions are needed. Because of the high energy of the photons in PT the first option might not be adequate, as the photon is not absorbed in general. However, the second option is less efficient. That is the reason to resort to spectral reconstructions, where the incoming γ energy is considered as a variable in the reconstruction inverse problem. Jointly with prompt gamma, secondary neutrons and scattered photons, not strongly correlated with the dose map, can also reach the imaging detector and produce false events. These events deteriorate the image quality. Also, high intensity beams can produce particle accumulation in the camera, which lead to an increase of random coincidences, meaning events which gather measurements from different incoming particles. The noise scenario is expected to be different if double or triple events are used, and consequently, the reconstructed images can be affected differently by spurious data. The aim of the present work is to study the effect of false events in the reconstructed image, evaluating their impact in the determination of the beam particle ranges. A simulation study that includes misidentified events (neutrons and random coincidences) in the final image of a Compton Telescope for PT monitoring is presented. The complete chain of detection, from the beam particle entering a phantom to the event classification, is simulated using FLUKA. The range determination is later estimated from the reconstructed image obtained from a two and three-event algorithm based on Maximum Likelihood Expectation Maximization. The neutron background and random coincidences due to a therapeutic-like time structure are analyzed for mono-energetic proton beams. The time structure of the beam is included in the simulations, which will affect the rate of particles entering the detector.


Subject(s)
Algorithms , Diagnostic Imaging/methods , Gamma Cameras , Image Processing, Computer-Assisted/methods , Phantoms, Imaging , Proton Therapy , Signal-To-Noise Ratio , Computer Simulation , Humans , Monte Carlo Method , Neutrons , Photons , Probability
15.
Minerva Pediatr ; 66(5): 381-414, 2014 Oct.
Article in Italian | MEDLINE | ID: mdl-25253187

ABSTRACT

Obesity in childhood is associated with the presence of complications that can undermine health immediately or in the long term. Several conditions, such as pulmonary or orthopedic complications are strictly associated with the severity of overweight, since they are directly associated to the mechanic stress of fat tissue on the airways or on the bones. Other conditions, such as metabolic or liver complications, although increasing with the extent of overweight, are associated with insulin resistance, which can be modulated by different other factors (ethnicity, genetics, fat distribution) and can occur in overweight children as well. No less important are psychological correlates, such as depression and stigma, which can seriously affect the health related quality of life. Pediatric services for the care of childhood obesity need to be able to screen overweight and obese children for the presence of physical and psychological complications, which can be still reversed by weight loss. This article provides pediatricians a comprehensive update on the main complications in obese children and adolescents and their treatment.


Subject(s)
Cardiovascular Diseases/etiology , Depression/etiology , Health Status , Insulin Resistance , Musculoskeletal Diseases/etiology , Obesity/complications , Respiratory Tract Diseases/etiology , Adolescent , Behavior Therapy , Body Mass Index , Cardiovascular Diseases/epidemiology , Child , Counseling , Depression/epidemiology , Diabetes Complications/epidemiology , Humans , Italy/epidemiology , Life Style , Musculoskeletal Diseases/epidemiology , Obesity/epidemiology , Obesity/therapy , Overweight/complications , Prevalence , Respiratory Tract Diseases/epidemiology , Risk Factors , Weight Loss
16.
Phys Med Biol ; 58(9): 2879-99, 2013 May 07.
Article in English | MEDLINE | ID: mdl-23571094

ABSTRACT

Monte Carlo simulations play a crucial role for in-vivo treatment monitoring based on PET and prompt gamma imaging in proton and carbon-ion therapies. The accuracy of the nuclear fragmentation models implemented in these codes might affect the quality of the treatment verification. In this paper, we investigate the nuclear models implemented in GATE/Geant4 and FLUKA by comparing the angular and energy distributions of secondary particles exiting a homogeneous target of PMMA. Comparison results were restricted to fragmentation of (16)O and (12)C. Despite the very simple target and set-up, substantial discrepancies were observed between the two codes. For instance, the number of high energy (>1 MeV) prompt gammas exiting the target was about twice as large with GATE/Geant4 than with FLUKA both for proton and carbon ion beams. Such differences were not observed for the predicted annihilation photon production yields, for which ratios of 1.09 and 1.20 were obtained between GATE and FLUKA for the proton beam and the carbon ion beam, respectively. For neutrons and protons, discrepancies from 14% (exiting protons-carbon ion beam) to 57% (exiting neutrons-proton beam) have been identified in production yields as well as in the energy spectra for neutrons.


Subject(s)
Heavy Ion Radiotherapy/methods , Monte Carlo Method , Proton Therapy , Radiotherapy Planning, Computer-Assisted/methods , Neutrons , Radiotherapy Dosage , Time Factors
17.
Nutr Metab Cardiovasc Dis ; 23(10): 1031-6, 2013 Oct.
Article in English | MEDLINE | ID: mdl-23466181

ABSTRACT

BACKGROUND AND AIMS: Type 1 diabetes (T1DM) affects young people during the most active years of their life. Our aim was to assess quality of life (QoL) and associated variables in a large cohort of adults with childhood-onset and adult-onset T1DM. METHODS: A cohort of adult patients (18 years and older) from the T1DM Registry of Turin, Italy, was recruited. Clinical characteristics and Diabetes QoL (DQOL) questionnaire were assessed by standardized procedures. RESULTS: 310 adults completed the questionnaire. Age and diabetes duration at assessment (mean ± SD) were 32.8 ± 7.3 years and 17.3 ± 6.3 years, respectively. DQOL and its subscores were in the lower quartiles of their distributions, indicating a good level of QoL. However, scores were significantly higher in females than in males, particularly for the subscale of diabetes-related worries. In multivariate analysis, lower QoL was independently associated with female sex (ß = 1.07, 95% CI 1.03-1.11, p = 0.003), higher age at onset (ß = 1.03, 1.00-1.05, p = 0.009), lower schooling (ß = 1.05, 1.00-1.09, p = 0.02), higher fasting plasma glucose (ß = 1.03, 1.01-1.05, p = 0.008), daily SMBG >4 (ß = 1.06, 1.01-1.10, p = 0.01), severe hypoglycemia over the last year (ß = 1.06, 1.01-1.11, p = 0.02), lower numbers of diabetologic visits (ß = 1.07, 1.01-1.13, p = 0.02) and hypertension (ß = 1.06, 1.02-1.10, p = 0.005). Autonomic neuropathy was associated with diabetes impact. Female sex (ß = 4.36, 2.43-7.83) and daily SMBG >4 (ß = 3.77, 1.72-8.30) were independently associated with worst level and CSII with better level (ß = 0.22, 0.07-0.68) of diabetes-related worries. CONCLUSIONS: The impact of T1DM on QoL may depend on demographic, metabolic control-related variables, presence of complications and insulin delivery modality.


Subject(s)
Aging , Attitude to Health , Diabetes Complications/epidemiology , Diabetes Mellitus, Type 1/epidemiology , Hypoglycemic Agents/therapeutic use , Insulin/therapeutic use , Quality of Life , Adult , Age of Onset , Cohort Studies , Cost of Illness , Cross-Sectional Studies , Diabetes Mellitus, Type 1/complications , Diabetes Mellitus, Type 1/drug therapy , Female , Follow-Up Studies , Humans , Hypertension/complications , Hypertension/epidemiology , Hypoglycemic Agents/administration & dosage , Insulin/administration & dosage , Italy/epidemiology , Male , Middle Aged , Registries , Self Report , Sex Characteristics , Young Adult
18.
Phys Rev Lett ; 110(2): 022501, 2013 Jan 11.
Article in English | MEDLINE | ID: mdl-23383895

ABSTRACT

The 63Ni(n,γ) cross section has been measured for the first time at the neutron time-of-flight facility n_TOF at CERN from thermal neutron energies up to 200 keV. In total, capture kernels of 12 (new) resonances were determined. Maxwellian averaged cross sections were calculated for thermal energies from kT=5-100 keV with uncertainties around 20%. Stellar model calculations for a 25M⊙ star show that the new data have a significant effect on the s-process production of 63Cu, 64Ni, and 64Zn in massive stars, allowing stronger constraints on the Cu yields from explosive nucleosynthesis in the subsequent supernova.

19.
Clin Ter ; 163(5): e269-77, 2012.
Article in English | MEDLINE | ID: mdl-23099973

ABSTRACT

PURPOSE: To evaluate with criticism the available evidence shown in the literature about the efficacy of pneumotrabeculoplasty (PNT) as a treatment for primary open angle glaucoma. MATERIALS AND METHODS: PNT is a recent non-surgical and noninvasive technique to safely reduce the intraocular pressure (IOP) in eyes suffering from ocular hypertension or primary open angle glaucoma. The technique consists in the application on the ocular surface of a disposable suction ring that induces a temporary trabecular meshwork stretching, increasing outflow of aqueous humor in the Schlemm's canal. In our study, we compared the results on the efficacy and safety of this treatment published to date in the literature. RESULTS: During follow-up, Authors have observed significant reductions in IOP in about 70% of treated eyes. The first treatment consists in 3 applications at day 0, 7 and 90, repeatable every 90 days. Immediately after suction ring application there is a significant elevation of IOP, however, of short duration and without demonstrable visual field worsening. Side effects observed are of little clinical significance and spontaneously resolving in a short time. CONCLUSIONS: The PNT is a safe and effective technique to reduce IOP in patients with ocular hypertension or open-angle glaucoma. It is repeatable, but can not replace drug treatment in patients already receiving topical therapy for glaucoma; however, it has proven effectiveness in maintaining an IOP target over time if accompanied with only a single topical drug, favoring a reduction of antiglaucoma drugs in polytherapy and increasing the compliance with treatment.


Subject(s)
Glaucoma, Open-Angle/surgery , Trabeculectomy/methods , Glaucoma, Open-Angle/physiopathology , Humans , Intraocular Pressure
20.
Minerva Stomatol ; 61(3): 65-73, 2012 Mar.
Article in English, Italian | MEDLINE | ID: mdl-22402297

ABSTRACT

AIM: Aim of this study was to evaluate two different luting cements and how their clinical procedures influence the postcementation quality. METHODS: Thirty-six freshly extracted mono-radicular teeth (N.=18) were treated endodontically and randomly divided into two groups. Posts were cemented respectively with two different self adhesive luting cements: Group A - RelyX Unicem (3M Espe) and Group B - Multilink Sprint (Ivoclar-Vivadent) following the manufacturers' instructions. Teeth were then thermocycled according to protocol ISO/TR 11405 and were immersed 24 hours in 2% methylene-blue solution. Each tooth was sectioned by a diamond-coated saw (Isomet-Buhler) from CEJ to apex. Each slice was examined for the presence or absence of gutta-percha remnants, voids, bubbles, dye infiltration degree and polymerization grade of the luting agent. Findings were evidenced by stereoscopic microscopy (30x) and Micro-Raman spectroscopy. Mann-Whitney and ANOVA statistical analyses were performed for all results. RESULTS: No statistical significances were evidenced for gutta-percha presence, dye infiltration and polymerization degree. Voids were present mostly in Group B and bubbles in Group A. Both differences were statistically significant. CONCLUSION: Materials and protocols for glass fiber posts cementation are fundamental for the clinical success. Self adhesive luting cements, if used correctly, could be an acceptable and quick luting agent for postcementation.


Subject(s)
Cementation/methods , Dental Cements , Dental Materials , Dentin-Bonding Agents , Glass , Polymerization , Resin Cements , Humans , In Vitro Techniques
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