ABSTRACT
In previous studies, a new IVF method of intracytoplasmic morphologically selected sperm injection (IMSI) was introduced, based on motile sperm organellar morphology examination (MSOME). It was concluded that microinjection of morphologically selected sperm cells with strictly normal nucleus, defined by MSOME, improves IVF-ICSI outcome. The aim of the present study was to confirm this conclusion in new, enlarged study groups. Comparison between 80 couples, who underwent an IVF-IMSI trial, with matched couples, who underwent a standard IVF-ICSI procedure, confirmed that pregnancy rate following IVF-IMSI was significantly higher, and abortion rate significantly lower than in the routine IVF-ICSI (60.0 versus 25.0%, and 14 versus 40% respectively, P Subject(s)
Fertilization in Vitro/methods
, Spermatozoa/cytology
, Spermatozoa/physiology
, Adult
, Case-Control Studies
, Female
, Humans
, Male
, Pregnancy
, Pregnancy Outcome
, Pregnancy Rate
, Sperm Injections, Intracytoplasmic/methods
, Sperm Motility