ABSTRACT
Anti-galactocerebroside (Gal-C) antibodies are present in patients with conditions such as Guillain-Barré syndrome and mycoplasma pneumonia. We report a rare case of left vocal cord paralysis in a patient with anti-Gal-C IgG antibodies that improved after administeration of antivirals and steroids.
Subject(s)
Galactosylceramides , Vocal Cord Paralysis , Humans , Galactosylceramides/immunology , Vocal Cord Paralysis/etiology , Antiviral Agents/therapeutic use , Immunoglobulin G/blood , Male , Autoantibodies/blood , Treatment Outcome , Female , Middle AgedABSTRACT
Mikulicz's disease, an immunoglobulin G4-related disease (IgG4-RD) occurs frequently in the head and neck region but rarely in the larynx. We report a case of IgG4-RD with pseudotumor formation in the larynx. A 50-year-old man presented at our facility for a complete physical examination and diagnostic testing of a left arytenoid tumor. On examination, a large supraglottic mass was noted with signs of dyspnea. Movement disorder of the vocal fold was absent. The patient underwent surgery with general anesthesia to improve respiratory symptoms and a resected specimen was submitted for diagnosis. The pathology findings revealed lymph follicle formation, interstitial follicular fibrosis, angiogenesis, and inflammatory cell infiltration with plasmacytosis. Immunohistologic staining at high magnification revealed one hundred or more IgG4-positive plasma cells and fifty percent IgG4/IgG. In addition, obliterative phlebitis was observed. Medical history was positive for retroperitoneal fibrosis with serum IgG4 levels below the diagnostic criteria of IgG4-RD, but histological characteristics of IgG4-RD were met. The diagnosis of IgG4-RD was established, oral treatment with prednisolone (0.6 mg/kg/day) was initiated, and the tumor reduced in size. IgG4-RD may cause irreversible functional impairment. Early diagnosis and treatment are important in reducing the risk of permanent impairment of vocal fold mobility.
Subject(s)
Granuloma, Plasma Cell/pathology , Immunoglobulin G4-Related Disease/pathology , Laryngeal Diseases/pathology , Glucocorticoids/therapeutic use , Granuloma, Plasma Cell/complications , Granuloma, Plasma Cell/therapy , Humans , Immunoglobulin G4-Related Disease/complications , Immunoglobulin G4-Related Disease/diagnostic imaging , Immunoglobulin G4-Related Disease/therapy , Laryngeal Diseases/complications , Laryngeal Diseases/diagnostic imaging , Laryngeal Diseases/therapy , Laryngoscopy , Laryngostenosis/etiology , Laryngostenosis/therapy , Laser Therapy , Male , Middle Aged , Positron-Emission Tomography , Prednisolone/therapeutic use , Retroperitoneal Fibrosis/complications , Stents , Tomography, X-Ray Computed , Tracheostomy , Ureteral Obstruction/diagnostic imaging , Ureteral Obstruction/etiology , Ureteral Obstruction/surgery , Video-Assisted SurgeryABSTRACT
OBJECTIVE: We reviewed the clinical anatomy of the anterior commissure and examined the effectiveness of a specialized spreader developed for optimal, efficient spreading of the thyroid cartilage in type II thyroplasty. STUDY DESIGN AND METHODS: The present study was a multicenter retrospective study of patients with spasmodic dysphonia who underwent a primary operation either before or after the introduction of a specialized spreader (in 2008 or 2014, respectively). In these patients, we examined the size of the titanium bridge used, the presence of perforation of the mucosa directly superior to the anterior commissure, and postoperative glottic findings. RESULTS: The sample comprised 39 and 40 patients who underwent surgery in 2008 and 2014, respectively. The mean size of the titanium bridge used during surgery was significantly smaller in 2014 (2.9 mm) than in 2008 (3.81 mm). Perforation of the laryngeal mucosa occurred in 13 patients in 2008 but occurred in only one patient in 2014. Based on glottic findings, spreading the thyroid cartilage using the specialized spreader was deemed to yield an effective glottic gap. CONCLUSIONS: In type II thyroplasty, the handling of the anterior commissure is the most important point. It is necessary to split the tendon and to spread the glottis while the tendon is joined with the cartilage. For this purpose, a specialized spreader was made. The use of a specialized spreader renders separation around the anterior commissure unnecessary, enabling minimally invasive spreading of the thyroid cartilage and thereby improving phonation.
Subject(s)
Dysphonia/surgery , Glottis/surgery , Laryngoplasty/methods , Tendons/surgery , Thyroid Cartilage/surgery , Adult , Dysphonia/diagnosis , Dysphonia/physiopathology , Equipment Design , Female , Glottis/physiopathology , Humans , Japan , Laryngeal Mucosa/injuries , Laryngoplasty/adverse effects , Laryngoplasty/instrumentation , Male , Phonation , Recovery of Function , Retrospective Studies , Surgical Instruments , Tendons/physiopathology , Thyroid Cartilage/physiopathology , Titanium , Treatment Outcome , Voice QualityABSTRACT
Posterior glottic stenosis (PGS) is a rare but life-threatening condition mostly caused by damage to the interarytenoid mucosa by an endotracheal tube. In surgical treatment of PGS, airway patency is prioritized, and the laryngeal functions involved in swallowing and phonation are considerably sacrificed. In the majority of cases, lateralization of a vocal fold or partial excision of a vocal fold and arytenoid cartilage results in glottal closure insufficiency and deterioration of phonatory function. We present the first report of transcricothyroid endoscopic subglottic surgery to treat a 46-year-old man with PGS who was intubated for 10 days. Postoperative hypofunction was not observed in the aerodynamic examination and acoustic analysis, and phonatory function has been maintained within normal limits.