Subject(s)
Kidney Transplantation , Adolescent , Child , Child, Preschool , Female , Graft Rejection/etiology , Graft Survival , Humans , Infant , Infant, Newborn , Infections/etiology , Kidney Transplantation/adverse effects , Kidney Transplantation/mortality , Male , Mexico/epidemiology , Sex Factors , Socioeconomic Factors , Survival Rate , Time FactorsABSTRACT
IgA nephropathy, also called Berger's disease, is characterized by recurrent gross hematuria or persistent microscopic hematuria, together with mesangial glomerular deposits of IgA found in the renal biopsy. Seven children with IgA nephropathy were studied. Most of them presented initially with recurrent macroscopic hematuria and low or moderate-grade proteinuria, without hypertension or renal function impairment. Only one patient presented with a rapidly progressive glomerulonephritis. Four patients did not receive any treatment; one of them is in remission, one has improved and two remain with moderate proteinuria and hematuria. One patient with significant proteinuria improved after prednisone and azathioprine treatment. The patient with rapidly progressive glomerulonephritis improved his renal function after oral prednisone and intravenous boluses of methylprednisolone and cyclophosphamide.
Subject(s)
Glomerulonephritis, IGA/diagnosis , Adolescent , Biopsy , Child , Child, Preschool , Female , Hematuria/diagnosis , Humans , Kidney/pathology , Male , Microscopy, Electron , Proteinuria/diagnosis , RecurrenceABSTRACT
Several renal and renal-related disturbances have been described in patients with AIDS (acquired immune deficiency syndrome), in adults and children as well. These are mainly electrolyte and acid-base imbalance, acute renal failure and nephrotic syndrome. The latter is usually steroid non-responder. The renal histopathological lesions described more commonly are minimal change, mesangial hyperplasia and focal segmental glomerulosclerosis. Herein, we describe a 5 year-old with AIDS, that developed nephrotic syndrome, characterized by edema, ascites, hypoalbuminemia and massive proteinuria. A percutaneous renal biopsy showed mesangial proliferation. She did not respond to a 6 week treatment with prednisone. She died with sepsis after several viral and bacterial infections.
Subject(s)
AIDS-Associated Nephropathy , Nephrotic Syndrome , Child, Preschool , Female , HumansABSTRACT
Africanized bees are unique in their aggressive behavior, characterized by massive attacks during which the victims are injected an important amount of venom. For this reason, Africanized bees are extremely dangerous. Their venom contains biological toxic substances, mainly mellitin, phospholipases, histamine, hyaluronidase and apamin. Non-sensitized persons that survive a massive attack may develop acute renal failure, as a consequence of the severe hemolysis, rhabdomyolysis and shock. These complications may lead to acute renal tubular necrosis. Also, the clinical pattern and treatment of the acute renal failure secondary to bee stings are discussed.