Subject(s)
Communicable Diseases, Imported/epidemiology , Communicable Diseases, Imported/virology , Disease Outbreaks , Measles virus/genetics , Measles/epidemiology , Measles/virology , Adult , Asia, Southeastern/epidemiology , Cluster Analysis , Genotype , Humans , Infection Control , Italy/epidemiology , Measles/transmission , Measles virus/classification , Measles virus/immunology , Measles virus/isolation & purification , Middle AgedABSTRACT
Human adenoviruses (HAdVs) cause a wide spectrum of clinical syndromes, depending on species and types, from mild respiratory infections to deadly pneumonia: in particular, severe infections occur in immunocompromised patients. In this report, we describe the case of a 36 years-old woman admitted to our intensive care unit (ICU) with severe respiratory distress syndrome caused by adenovirus pneumonia, that required invasive respiratory support (mechanical ventilation and extracorporeal membrane oxygenation). Molecular assays detected the virus in respiratory and plasma specimen and sequencing procedure identified HAdV type 4. Patient improved after cidofovir administration. Leukopenia and subsequent bacterial infection occurred, but the patient recovered completely and was discharged from the hospital after 54days.
Subject(s)
Adenovirus Infections, Human , Adenoviruses, Human/genetics , Respiratory Distress Syndrome , Adult , Critical Care , DNA, Viral/analysis , DNA, Viral/genetics , Female , Hospitalization , Humans , Molecular Typing , Polymerase Chain ReactionABSTRACT
The coding sequences of five human enterovirus (HEV)-C genotype 105 strains recovered in Italy, Romania and Burundi from patients with upper and lower respiratory tract infections were analysed and phylogenetically compared with other circulating HEV-C strains. The EV-C105 was closely related to EV-C109 and EV-C118 strains. The European strains were similar to other circulating EV-C105 strains, while the two African EV-C105 clustered in separate bootstrap-supported (>0.90) branches of the P2 and P3 region trees. Minor inconsistencies in the clustering pattern of EV-C105 in the capsid region (P1) and non-capsid region (P3) suggest that recombination may have occurred in EV-C105 group B viruses. In conclusion, phylogenetic analysis revealed the circulation of two distinct EV-C105 lineages in Europe and Africa. A different pattern of evolution could be hypothesized for the two EV-C105 lineages.