Subject(s)
Endocarditis, Bacterial/diagnosis , Staphylococcal Infections/diagnosis , Transcatheter Aortic Valve Replacement , Adult , Anti-Bacterial Agents , Endocarditis, Bacterial/drug therapy , Endocarditis, Bacterial/surgery , Humans , Male , Staphylococcal Infections/drug therapy , Staphylococcal Infections/surgery , Staphylococcus epidermidisSubject(s)
Endocarditis/etiology , Heart Failure/etiology , Staphylococcal Infections/etiology , Transcatheter Aortic Valve Replacement/adverse effects , Aged, 80 and over , Anti-Bacterial Agents/therapeutic use , Endocarditis/diagnostic imaging , Endocarditis/drug therapy , Heart Failure/diagnostic imaging , Heart Failure/therapy , Humans , Male , Staphylococcal Infections/diagnostic imaging , Staphylococcal Infections/drug therapy , Staphylococcus epidermidisSubject(s)
Factor VII Deficiency/drug therapy , Factor VIIa/adverse effects , Pulmonary Embolism/chemically induced , Factor VIIa/therapeutic use , Humans , Male , Middle Aged , Pulmonary Embolism/diagnostic imaging , Recombinant Proteins/adverse effects , Recombinant Proteins/therapeutic use , Urinary Bladder Neoplasms/surgeryABSTRACT
AIMS: The aim of the study was to evaluate the prognostic role of adipokines (adiponectin, apelin, resistin, and visfatin) in patients with acute myocardial infarction (AMI) in relation to the extent of glucose metabolism impairment and intensity of systemic low-grade inflammation. METHODS: This case-control study covered 131 patients with coronary artery disease: 104 consecutive patients with AMI (74% men, mean age of 62â±â11 years) treated with primary percutaneous coronary intervention with stent implantation, and 27 patients with stable angina (70% men, mean age of 63â±â11 years), who were initially assessed in terms of adipokine levels, C-reactive protein and various echocardiographic and vascular parameters. Major adverse cardiovascular events were recorded in the AMI group during 3-year follow-up. RESULTS: Resistin and visfatin serum levels were significantly higher (Pâ<â0.001), and adiponectin and apelin were lower (Pâ<â0.001) in AMI patients as compared to patients with stable angina. In AMI patients, adipokine levels were not related to glucose metabolism disturbances, yet adiponectin (Pâ=â0.03) and resistin (Pâ=â0.001) concentrations were related to the number of affected coronary vessels. Serum adiponectin level correlated negatively (râ=â-0.608, Pâ<â0.05), whereas resistin and visfatin correlated positively (râ=â0.526, Pâ<â0.05 and râ=â0.352, Pâ<â0.05, respectively) with C-reactive protein levels. All of the analyzed adipokines significantly accounted for the flow-mediated dilation variability (Radjusted 32%) in the AMI group. The Cox survival analysis indicated that resistin and visfatin were independent risk factors of recurrent AMI/unstable angina, with the diagnostic threshold above 12.2âng/ml for resistin and above 11.8âng/ml for visfatin concentrations. CONCLUSION: An abnormal profile in serum adipokines observed in AMI is related to systemic inflammation and the degree of atherosclerosis independently of glucose metabolism disturbances and heralds major adverse cardiovascular event occurrence in long-term observation.
Subject(s)
Adipokines/blood , Myocardial Infarction/blood , Aged , Angina, Stable/blood , Atherosclerosis/complications , Biomarkers/blood , Case-Control Studies , Endothelium, Vascular/physiopathology , Female , Glucose/metabolism , Humans , Inflammation/complications , Male , Middle Aged , Myocardial Infarction/diagnosis , Myocardial Infarction/physiopathology , Prognosis , Prospective Studies , Recurrence , Risk AssessmentABSTRACT
We present a case of a 70 year-old male with B-cell lymphoma of which the first clinical presentation was cardiac infiltration. The patient underwent full chemotherapy with complete tumour regression. Kardiol Pol 2011; 69, 10: 1063-1065.
Subject(s)
Drug Therapy/methods , Heart Neoplasms/pathology , Lymphoma, B-Cell/pathology , Aged , Electrocardiography , Heart Neoplasms/drug therapy , Humans , Lymphoma, B-Cell/drug therapy , Male , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
An incidence of sepsis, septic shock, systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) is still actual clinical problem. Inducing factors and clinical pictures are similar to recently reported data from comparable populations in North America, Europe and Australia. The most important complication of severe sepsis is organ dysfunction observed in over 30% of sepsis patients hospitalized in intensive care unit. Applied intensive therapy including new generations of antibiotics gives an increase in clinical recovery. However, a hospital mortality of sepsis patients is over 30%.