ABSTRACT
Chronic granulomatous disease (CGD) is an inherited primary immunodeficiency disorder with recurrent bacterial and fungal infections like Staphylococcus aureus, Nocardia spp, Serratia marcescens, Burkholderia cepacia, Salmonella spp. and Aspergillus species. We present a 13-year-old male child who had 3 episodes of tuberculosis (TB) at 5 years, 8 years and 13 years of age, respectively, with no other intercurrent infections and who was diagnosed as CGD at the age of 13 years. This case highlights the possibility of phenotypic variations of CGD. The diagnosis of CGD should also be sought in all children with recurrent TB.
Subject(s)
Granulomatous Disease, Chronic/diagnosis , Tuberculosis/diagnosis , Adolescent , Child , Diagnosis, Differential , Humans , Male , RecurrenceSubject(s)
Antitubercular Agents/pharmacology , Bacteriological Techniques/methods , Extensively Drug-Resistant Tuberculosis/diagnosis , Extensively Drug-Resistant Tuberculosis/microbiology , Mycobacterium tuberculosis/drug effects , Rifampin/pharmacology , Adolescent , Antitubercular Agents/therapeutic use , Child , Child, Preschool , Drug Resistance, Multiple, Bacterial , Extensively Drug-Resistant Tuberculosis/drug therapy , Humans , India , Infant , Rifampin/therapeutic use , Sensitivity and SpecificityABSTRACT
Pellagra is a disorder characterized by dermatitis, diarrhea, dementia and eventually death, resulting from a deficiency of niacin or its precursor tryptophan. Ethionamide (a second-line antituberculosis agent)-induced pellagra is rarely encountered in clinical practice. Prompt diagnosis and treatment with nicotinamide can prevent life-threatening complications. To date, only three cases have been reported. We report a 13-year-old girl presenting with ethionamide-induced pellagra that resolved after the administration of niacin.