Application of uncertainty quantification to artificial intelligence in healthcare: A review of last decade (2013-2023).

Uncertainty estimation in healthcare involves quantifying and understanding the inherent uncertainty or variability associated with medical predictions, diagnoses, and treatment outcomes. In this era of Artificial Intelligence (AI) models, uncertainty estimation becomes vital to ensure safe decision-making in the medical field. Therefore, this review focuses on the application of uncertainty techniques to machine and deep learning models in healthcare. A systematic literature review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Our analysis revealed that Bayesian methods were the predominant technique for uncertainty quantification in machine learning models, with Fuzzy systems being the second most used approach. Regarding deep learning models, Bayesian methods emerged as the most prevalent approach, finding application in nearly all aspects of medical imaging. Most of the studies reported in this paper focused on medical images, highlighting the prevalent application of uncertainty quantification techniques using deep learning models compared to machine learning models. Interestingly, we observed a scarcity of studies applying uncertainty quantification to physiological signals. Thus, future research on uncertainty quantification should prioritize investigating the application of these techniques to physiological signals. Overall, our review highlights the significance of integrating uncertainty techniques in healthcare applications of machine learning and deep learning models. This can provide valuable insights and practical solutions to manage uncertainty in real-world medical data, ultimately improving the accuracy and reliability of medical diagnoses and treatment recommendations.

Fusion of Higher Order Spectra and Texture Extraction Methods for Automated Stroke Severity Classification with MRI Images.

This paper presents a scientific foundation for automated stroke severity classification. We have constructed and assessed a system which extracts diagnostically relevant information from Magnetic Resonance Imaging (MRI) images. The design was based on 267 images that show the brain from individual subjects after stroke. They were labeled as either Lacunar Syndrome (LACS), Partial Anterior Circulation Syndrome (PACS), or Total Anterior Circulation Stroke (TACS). The labels indicate different physiological processes which manifest themselves in distinct image texture. The processing system was tasked with extracting texture information that could be used to classify a brain MRI image from a stroke survivor into either LACS, PACS, or TACS. We analyzed 6475 features that were obtained with Gray-Level Run Length Matrix (GLRLM), Higher Order Spectra (HOS), as well as a combination of Discrete Wavelet Transform (DWT) and Gray-Level Co-occurrence Matrix (GLCM) methods. The resulting features were ranked based on the p-value extracted with the Analysis Of Variance (ANOVA) algorithm. The ranked features were used to train and test four types of Support Vector Machine (SVM) classification algorithms according to the rules of 10-fold cross-validation. We found that SVM with Radial Basis Function (RBF) kernel achieves: Accuracy (ACC) = 93.62%, Specificity (SPE) = 95.91%, Sensitivity (SEN) = 92.44%, and Dice-score = 0.95. These results indicate that computer aided stroke severity diagnosis support is possible. Such systems might lead to progress in stroke diagnosis by enabling healthcare professionals to improve diagnosis and management of stroke patients with the same resources.

Future IoT tools for COVID-19 contact tracing and prediction: A review of the state-of-the-science.

In 2020 the world is facing unprecedented challenges due to COVID-19. To address these challenges, many digital tools are being explored and developed to contain the spread of the disease. With the lack of availability of vaccines, there is an urgent need to avert resurgence of infections by putting some measures, such as contact tracing, in place. While digital tools, such as phone applications are advantageous, they also pose challenges and have limitations (eg, wireless coverage could be an issue in some cases). On the other hand, wearable devices, when coupled with the Internet of Things (IoT), are expected to influence lifestyle and healthcare directly, and they may be useful for health monitoring during the global pandemic and beyond. In this work, we conduct a literature review of contact tracing methods and applications. Based on the literature review, we found limitations in gathering health data, such as insufficient network coverage. To address these shortcomings, we propose a novel intelligent tool that will be useful for contact tracing and prediction of COVID-19 clusters. The solution comprises a phone application combined with a wearable device, infused with unique intelligent IoT features (complex data analysis and intelligent data visualization) embedded within the system to aid in COVID-19 analysis. Contact tracing applications must establish data collection and data interpretation. Intelligent data interpretation can assist epidemiological scientists in anticipating clusters, and can enable them to take necessary action in improving public health management. Our proposed tool could also be used to curb disease incidence in future global health crises.