[Modulators of intracellular metabolism in the treatment of diseases of the internal ear]. / Moduliatory vnutrikletochnogo metabolizma v lechenii zabolevanii vnutrennego ukha.

Stress reactions develop in different organs as a result of the effect of unfavourable factors which increase the differential threshold for men. These derangements mainly occur in the organs where we can observe an inadequacy between high level of metabolism in the cell and instability of energy supply. Under such conditions stress reactions in the cells have the following stages in succession: intensiveness of the lipolysis in mitochondria, accumulation in the cells of fatty acid metabolites, destruction of the membranous apparatus of the cells, increase in the presence of Ca++ in the cells.

[Effects of induced hyperemia on the concentration of a labeled substance in the internal ear]. / Vliianie iskusstvennoi giperemii na kontsentratsiiu mechenogo veshchestva vo vnutrennem ukhe.

Cochlear neuroepithelial cells contain a lot of mitochondria which is an indication of a high rate of metabolism in the organ. However, blood flow in the internal ear is low because vessels of the stria vascularis have no muscular layer or vasomotor innervation. Therefore in case of a disease reactive hyperemia which may lead to the restoration of blood supply should not be expected. Internal ear circulation may be influenced by compressing internal jugular veins to produce venous hypertension and hyperemia. Rabbit experiments in which internal jugular veins were ligated showed that the concentration of a labeled substance in the ear preparation increased by 72.8% within an hour after intravenous injection as compared to the controls. This effect is due to an increase of transcapillary filtration and transmural permeability in the terminal circulation area. However, venous hyperemia has certain disadvantages which makes it necessary to develop better approaches to blood from control as a method of therapy of internal ear diseases.