ABSTRACT
BACKGROUND: The efficacy of combined aspiration catheter and stent retriever compared with stent retriever alone for the treatment of large-vessel occlusion acute ischemic stroke is unclear. PURPOSE: Our aim was to conduct a systematic literature review and meta-analysis on several metrics of efficacy comparing aspiration catheter and stent retriever with stent retriever alone. DATA SOURCES: MEDLINE and the Cochrane Library Databases were searched. Randomized controlled trials and case-control and cohort studies were included. STUDY SELECTION: Ten comparative studies were included detailing a combined 1495 patients with aspiration catheter and stent retriever and 1864 with stent retrievers alone. DATA ANALYSIS: Data on first pass effect (TICI 2b/2c/3 after first pass), final successful reperfusion (modified TICI ≥2b), and 90-day functional independence (mRS ≤ 2) were collected. Meta-analysis was performed using a random-effects model. DATA SYNTHESIS: There was a pooled composite first pass effect of 40.8% (611/1495) versus 32.6% (608/1864) for aspiration catheter and stent retriever and stent retriever alone, respectively (P < .0001). Similarly, on a meta-analysis, aspiration catheter and stent retriever were associated with a higher first pass effect compared with stent retriever alone (OR = 1.63; 95% CI, 1.20-2.21; P = .002; I2 = 72%). There was no significant difference in composite rates of successful reperfusion between aspiration catheter and stent retriever (72.8%, 867/1190) and stent retriever alone (70.8%, 931/1314) (P = .27) or on meta-analysis (OR = 1.31; CI, 0.81-2.12; P = .27; I2 = 82%). No difference was found between aspiration catheter and stent retriever and stent retriever alone on 90-day functional independence (OR = 1.02; 95% CI, 0.77-1.36; P = .88; I2 = 40%). LIMITATIONS: This study is limited by high interstudy heterogeneity. CONCLUSIONS: On meta-analysis, aspiration catheter and stent retriever are associated with a superior first pass effect compared with stent retriever alone, but they are not associated with statistically different final reperfusion or functional independence.
Subject(s)
Arterial Occlusive Diseases , Brain Ischemia , Ischemic Stroke , Stroke , Arterial Occlusive Diseases/complications , Brain Ischemia/complications , Brain Ischemia/surgery , Catheters , Humans , Retrospective Studies , Stents , Stroke/complications , Thrombectomy , Treatment OutcomeABSTRACT
Twenty cases of unusual thorny foreign bodies (seeds of Xanthium strumarium) in laryngo-pharynx area are reported. The aetiopathogenesis, clinical features and management are briefly discussed.
Subject(s)
Foreign Bodies , Larynx , Pharynx , Seeds , Adolescent , Child , Child, Preschool , Female , Humans , India , MaleABSTRACT
Serum 5-nucleotidase levels have been estimated in a group of 50 patients with head and neck cancer. The mean value was significantly higher in patients compared to the controls. In patients with non-malignant growths, the activity was comparable with the controls. The increase was higher in patients with proliferative lesions than those with ulcerative growths. Enzyme activity was found to be increased with the advancement in the stage of cancer. The rise was comparatively higher in patients with cervical metastasis. After radiotherapy, a gradual and significant reduction of serum 5-nucleotidase activity was observed.
Subject(s)
Head and Neck Neoplasms/enzymology , Nucleotidases/blood , 5'-Nucleotidase , Adult , Aged , Aged, 80 and over , Female , Head and Neck Neoplasms/pathology , Head and Neck Neoplasms/radiotherapy , Humans , Lymphatic Metastasis , Male , Middle Aged , Neoplasm Metastasis , Neoplasm StagingABSTRACT
Serum magnesium levels have been estimated in 25 patients with head and neck cancer. The results have been compared with a group of 25 healthy controls. In cancer patients the mean value was significantly reduced when compared with the control group. A progressive, and significant, increase in serum magnesium concentration was observed following radiotherapy.
Subject(s)
Head and Neck Neoplasms/blood , Magnesium/blood , Adolescent , Adult , Aged , Aged, 80 and over , Carcinoma, Squamous Cell/blood , Female , Head and Neck Neoplasms/pathology , Head and Neck Neoplasms/radiotherapy , Humans , Male , Middle Aged , Neoplasm StagingSubject(s)
Bronchi , Foreign Bodies , Play and Playthings , Child , Child, Preschool , Female , Humans , MaleSubject(s)
Nasal Polyps/pathology , Adult , Female , Glycosaminoglycans/analysis , Humans , Male , Nasal Polyps/analysis , Nasal Polyps/etiologyABSTRACT
Serum aliesterase levels have been estimated in 38 patients with head and neck cancer. The mean value was significantly lower than in controls. The decrease in activity was greater in patients with ulcerative growths and it progressed with advancement in the stage of cancer. With radiotherapy, a progressive and significant increase in serum aliesterase activity was observed. In patients with non-malignant growths the activity was comparable with that in controls.
Subject(s)
Carboxylic Ester Hydrolases/blood , Head and Neck Neoplasms/enzymology , Adult , Aged , Aged, 80 and over , Carboxylesterase , Female , Head and Neck Neoplasms/radiotherapy , Humans , Male , Middle AgedSubject(s)
Esophagus , Foreign Bodies , Adolescent , Adult , Child , Child, Preschool , Esophagoscopy , Female , Foreign Bodies/diagnosis , Foreign Bodies/therapy , Humans , Male , Middle AgedABSTRACT
Serum phosphohexose isomerase (PHI) levels were estimated in 28 patients with head and neck cancer. The mean value was significantly higher when compared to the controls. There was no difference in mean PHI value with respect to the character of the lesion or with the histopathological type of growth. The activity was increased with the advancement of the stage of cancer. With radiotherapy, a gradual and significant decrease in serum PHI activity was observed.