1.
Analyst
; 142(9): 1429-1433, 2017 May 02.
Article
in English
| MEDLINE
| ID: mdl-28322385
ABSTRACT
Imaging tumoral pH may help to characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2-13C,D10]diethylmalonic acid, which exhibits a large pH-dependent 13C chemical shift over the physiological range. We demonstrate that co-polarization with [1-13C,D9]tert-butanol accurately measures pH via13C NMR and magnetic resonance spectroscopic imaging in phantoms.
Subject(s)
Carbon Isotopes/chemistry , Dicarboxylic Acids/chemistry , Magnetic Resonance Imaging , Magnetic Resonance Spectroscopy , Hydrogen-Ion Concentration , Phantoms, Imaging
2.
Chem Commun (Camb)
; 52(14): 3030-3, 2016 Feb 18.
Article
in English
| MEDLINE
| ID: mdl-26792559
ABSTRACT
A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized (13)C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized (13)C pH imaging in a phantom and in vivo in a murine model of prostate cancer.