Histopathology-driven prostate cancer identification: A VBIR approach with CLAHE and GLCM insights.

Efficient extraction and analysis of histopathological images are crucial for accurate medical diagnoses, particularly for prostate cancer. This research enhances histopathological image reclamation by integrating Visual-Based Image Reclamation (VBIR) techniques with contrast-limited adaptive Histogram Equalization (CLAHE) and the Gray-Level Co-occurrence Matrix (GLCM) algorithm. The proposed method leverages CLAHE to improve image contrast and visibility, crucial for regions with varying illumination, and employs a non-linear Support Vector Machine (SVM) to incorporate GLCM features. Our approach achieved a notable success rate of 89.6%, demonstrating significant improvement in image analysis. The average execution time for matched tissues was 41.23 s (standard deviation 36.87 s), and for unmatched tissues, 21.22 s (standard deviation 29.18 s). These results underscore the method's efficiency and reliability in processing histopathological images. The findings from this study highlight the potential of our method to enhance image reclamation processes, paving the way for further research and advancements in medical image analysis. The superior performance of our approach signifies its capability to significantly improve histopathological image analysis, contributing to more accurate and efficient diagnostic practices.

Effect of groundwater nutrients on coastal phytoplankton community composition in the Bay of Bengal, India: An experimental study.

Submarine groundwater discharge is a pivotal factor in modifying the structure of phytoplankton communities in coastal waters. The objective of the study was to investigate how variations in nutrient concentrations and ratios influence the composition of phytoplankton communities along the coastal waters of Bay of Bengal. The experiment involved mixing groundwater with coastal water at 5 % and 10 % proportions. Phytoplankton growth was more pronounced in 10 % groundwater than those with 5 % and control samples. In control samples, Chl-a and other pigments, experienced decrease from 20 % to 80 %, except in Odisha-Paradeep and Visakhapatnam-Andhra Pradesh, where peridinin concentrations increased by 60 % to 65 % owing to low Si:N ratios below 0.2. A shift was observed from diatoms to dinoflagellates due to low Si: N ratios. The results reaffirm the hypothesis that variations in nutrient concentrations and ratios play a substantial role in shaping the composition of phytoplankton in the adjacent coastal waters.

Canalicular Adenoma of Parotid- A Rare Case Report.

Salivary gland canalicular adenoma is rare yet benign. It accounts for fewer than 1% of salivary tumors and is the third most common non-cancerous mass in the small salivary glands. A 45-year-old presented to the outpatient department with complaints of swelling in the left parotid region for the past 3 years. Examination revealed a firm swelling in the left parotid region. USG and MRI revealed features suggestive of pleomorphic adenoma. Superficial parotidectomy was planned but intra-operatively, the mass was seen between the two lobes of the parotid, which was removed, and on histopathological examination, it was diagnosed as canalicular adenoma. Post-operatively, the patient's condition is excellent.

Enhancing HVDC transmission line fault detection using disjoint bagging and bayesian optimization with artificial neural networks and scientometric insights.

DC grid fault protection techniques have previously faced challenges such as fixed thresholds, insensitivity to high-resistance faults, and dependency on specific threshold settings. These limitations can lead to elevated fault currents in the grid, particularly affecting multi-modular converters (MMCs) vulnerability to large fault current transients. This paper proposes a novel approach that combines the disjoint-based Bootstrap Aggregating (Bagging) technique and Bayesian optimization (BO) for fault detection in DC grids. Disjoint partitions reduce variance and enhance Ensemble Artificial Neural Network (EANN) performance, while BO optimizes EANN architecture. The proposed approach uses multiple transient periods instead of a fixed time to train the model. Transient periods are segmented into multiple 1 ms intervals, and each interval trains a separate neural network. In this way, a robust local relay is created that does not require high-speed communication systems. Additionally, a discrete wavelet transform (DWT) is applied to select detailed coefficients of the transient fault current, measured at the DC line's sending terminal for fault protection. EANN is trained in comprehensive offline data that considers noise impact. Simulation results demonstrate the scheme's ability to detect faults as high as 400 Ω accurately. This makes it a robust, reliable, and effective solution for fault detection on high-voltage direct current (HVDC) transmission lines. Lastly, this research provides the first-ever scientometric analysis of HVDC transmission line fault protection using neural network algorithms, highlighting major research themes and trends. The scientometric analysis was based on a dataset of 136 available research articles from the Scopus database from the last ten years. Therefore, this research provides valuable insights into the use of ANN for HVDC transmission line fault protection.

External validation of dementia prediction models in Black or African American and White older adults: A longitudinal population-based study in the United States.

INTRODUCTION: Identifying people at high risk of Alzheimer's disease (AD) dementia allows for timely intervention, which, if successful, will result in preventing or delaying the onset of the disease. METHODS: Utilizing data from the Chicago Health and Aging Project (CHAP; n = 2130), we externally evaluated four risk-prediction models for AD dementia, including Cardiovascular Risk Factors, Aging, and Dementia (CAIDE), Australian National University Alzheimer's Disease Risk Index (ANU-ADRI), Brief Dementia Screening Indicator (BDSI), and Dementia Risk Score (DRS), in Black or African American and White adults. RESULTS: BDSI had the highest discriminate abilities for AD dementia (c-statistics of 0.79 in Black and 0.77 in White adults), followed by ANU-ADRI, within the age range and follow-up period of the original development cohort. CAIDE had the lowest discriminating power (c-statistic ≤0.55). With increasing follow-up periods (i.e., 10-15 years), the discrimination abilities for all models declined. DISCUSSION: Because of racial disparities in AD dementia and longer preclinical and prodromal stages of disease development, race-specific models are needed to predict AD risk over 10 years. HIGHLIGHTS: Utilizing risk-prediction models to identify individuals at higher risk of Alzheimer's disease (AD) dementia could benefit clinicians, patients, and policymakers. Clinicians could enroll high-risk individuals in clinical trials to test new risk-modifiable treatments or initiate lifestyle modifications, which, if successful, would slow cognitive decline and delay the onset of the disease. Current risk-prediction models had good discriminative power during the first 6 years of follow-up but decreased with longer follow-up time. Acknowledging the longer preclinical phase of AD dementia development and racial differences in dementia risk, there is a need to develop race-specific risk-prediction models that can predict 10 or 20 years of risk for AD and related dementias.

Enantioselective Separation and Pharmacokinetics of a Chiral 1,4-Dihydropyrimidine Derivative in Rats: A Combined Chromatography and Docking Approach.

Chirality in 1,4-Dihydropyrimidines influences their pharmacological properties and synthetic strategies. Enantiomers of chiral drugs often exhibit different pharmacokinetic profiles. Therefore, separating and studying individual enantiomers is crucial to optimize drug efficacy and safety. Enantiomeric separation of ±4-(4-chlorophenyl)-6-methyl-2-oxo-N-(O-toyl)-1,2,3,4-tetrahydropyrimidine-5-carboxamide (DP-1), which is a 1,4-Dihydropyrimidine derivative is achieved on CHIRALCEL® OD-H column (particle size: 5 µm, inner diameter: 4.6 mm, length:150 mm), following by investigating the kinetic properties of (R) and (S) enantiomers. The separation was achieved with a mobile phase composed of 70% (v/v) isopropyl alcohol and 30% (v/v) n-hexane. For the bioanalytical study, acetonitrile was used to precipitate the rat plasma samples and validated the method according to USFDA guidelines. The validated bioanalytical method was then successfully applied to determine the pharmacokinetic parameters of the drug in biological samples. Molecular modeling techniques, specifically docking simulations, were employed to predict the elution order of DP-1 enantiomers. The docking results revealed moderate binding interactions between the enantiomers and the chiral stationary phase (CSP), which aligns with the theoretical expectation that stronger interactions lead to longer retention times on the column.

Reversal of insulin resistance to combat type 2 diabetes mellitus by newer thiazolidinedione's in fructose induced insulin resistant rats.

In our pursuit of discovering new antidiabetic agents to manage type 2 diabetes mellitus (T2DM), our approach aimed to identify the bioactive feature/pharmacophore responsible for PPAR-γ expression, as it is accountable for the glucose homeostasis and lipid metabolism. This was achieved by pharmacophore model generation, screening of rationally designed newer thiazolidinedione's library, identifying synthesizing and characterizing the top ten molecules (5a-5j) for their (Invitro & invivo) antidiabetic activity. Preliminary screening of all the ligands by Invitro glucose uptake assay in L6 myotubes (skeletal muscle cell line of rats) revealed compound 5b and 5f stimulated the glucose uptake with 79.29 ± 1.02 % and 74.58 ± 1.02 % respectively compared to pioglitazone with 82.36 ± 0.98 %. This was validated by PPAR-γ TF expression assay, which highlighted a dose dependent increase in transactivation of PPAR-γ. These compounds 5b and 5f were evaluated in fructose induced insulin resistance rat model. Where the treatment with 5b and 5f markedly increased the exogenous clearance of glucose and exogenous insulin via OGTT and ITT respectively, also improved the glucose utilization by significantly increasing content of glycogen and uptake of glucose in rat hemidiaphragm and reversed insulin resistance. Likewise a significant decreased in the VLDL and triglyceride levels was seen in 5b and 5f treated groups compared to insulin resistant (IR) group. It improved glycogenesis by catabolism of glucose and maintained glycaemic control. Similarly it had marked action on enzymatic oxidative biomarkers. Compound 5b displayed better, improved T1/2 (half-life) of 4.21 h and Kel (elimination constant) of 0.381 was noticed in comparison to compound 5f indicating the pharmacokinetic profile. Insilico studies like DFT calculations refined the geometry of 5b and 5f ligands, docking and molecular simulation provided the insights in binding affinity, dynamic behaviour and stability of ligands in PPAR-γ ligand binding domain. MM/GBSA provided the energetics of 5b and 5f in binding pocket. Finally network pharmacology identified ADIPOQ (adiponectin), NR1C3 (PPAR-γ), SLC2A4 (GLUT4), and LEP (leptin) proteins associate with compound 5b and 5f and enriched in Adipocytokine pathway, and PPAR-γ signaling pathway.

Association of MIND diet with cognitive decline among Black and White older adults.

INTRODUCTION: We examined the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet's association with cognitive decline by race among older adults in the Chicago Health and Aging Project. METHODS: Five thousand two hundred fifty-nine participants (73.5 [± 6.0] years, 62% Black participants, 62% female) completed a food frequency questionnaire, and two or more cognitive assessments over 7.8 ± 4.6 years. RESULTS: Overall, higher MIND diet was associated with slower cognitive decline (p for trend = 0.0025). The MIND score (range:0-15) was different between Black and White older adults(6.97 vs. 7.12, p = 0.010). Compared to the lowest tertile, among White participants, the two highest tertiles (MIND score -7: ß = 0.0121 [95% confidence interval [CI]: 0.0006, 0.0237]; MIND score -8.5: ß = 0.0146 [95% CI: 0.0003, 0.0260]) and among Black participants, only the highest tertile (MIND score -8.5: ß = 0.0088 [95% CI: 0.0003, 0.0172]) had association with cognitive decline. Vascular and lifestyle factors attenuated the association only for Black older adults. DISCUSSION: The MIND diet was associated with slower cognitive decline in Black and White older adults, but this may vary with other lifestyle and vascular factors. Further research is warranted on race-specific cultural diets considering other risk factors for cognitive decline. HIGHLIGHTS: The intake of Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet components varies by race. The MIND diet may slow cognitive decline in both Black and White older adults. This association may vary with other lifestyle and vascular risk factors.

Monomelittoside and Dichotomoside D from bark extract of Alstonia scholaris (L.) R. Br. inhibits dental caries pathogen Streptococcus mutans.

Dental caries advances to be a significant global health concern, primarily attributed to the virulent actions of Streptococcus mutans. The antibacterial property of the bark extract of Alstonia scholaris was assessed using standard disc diffusion assays, which revealed significant inhibition of S. mutans. Subsequently, we determined the Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) revealed potent antibacterial activity of bark extract against S. mutans, at MIC and MBC values 62.5 and 125 µg/mL, respectively and antibiofilm activity at 125 µg/mL. Furthermore, cytotoxicity assays showed no adverse effects on mammalian cells. Moreover, we employed liquid chromatography-mass spectrometry to identify bioactive compounds in the bark extract and revealed the presence of major active compounds as Monomelittoside and Dichotomoside D effective in targeting the S. mutans. These findings showed that, the promising antibacterial efficacy of Monomelittoside and Dichotomoside D, highlighting their potential as natural therapeutics for combating dental caries.

From the discovery of a novel arepavirus in diseased arecanut palms (Areca catechu L.) in India to the identification of known and novel arepaviruses in bee and plant transcriptomes through data-mining.

Arecanut palm is a commercially important plantation crop valued for its nut. In this investigation, we report the discovery of a putative novel arepavirus, named areca palm necrotic ringspot virus 2 (ANRSV2), in necrotic ringspot diseased areca palms in Bantwal, Dakshina Kannada, Karnataka, India through RNA-sequencing and transmission electron microscopy. Further, the presence of ANRSV2 in the diseased samples was confirmed through reverse transcriptase-polymerase chain reaction assays. In addition, by mining public domain transcriptome data for arepaviral sequences, we identified a putative novel arepavirus in Psychotria rubra, a non-palm host. We recovered the genome sequences of the areca palm necrotic ringspot virus in honey bees, tomato, Onobrychis viciifolia, and Rhamnus heterophylla. These findings broaden our comprehension of arepaviral diversity and host range, and suggest an intriguing possibility of pollen-mediated arepaviral transmission that necessitates empirical validation. Further studies are needed to understand the biology of identified putative novel arepaviruses.

Comparison between Metal Mesh and Iliac Bonegraft in the Reconstruction of Orbital Floor Fracture-A Clinical Study.

Background: After face trauma, orbital floor fractures are often experienced, leading to both functional and cosmetic deficits. There are several methods for reconstructing the orbital floor, such as iliac bone grafting and metal mesh. There are not many comparison studies available, nevertheless, to help surgeons choose the best method. Methods: Fifty patients with orbital floor fractures were enrolled in this prospective, randomized clinical investigation. They were randomly allocated to receive either an iliac bone transplant (n = 25) or metal mesh (n = 25). Over the course of six months, postoperative complications such as diplopia and enophthalmos were assessed regularly. A statistical study was conducted to compare the two groups' results. Results: There was no discernible difference in postoperative complications between the two groups when it came to the reconstruction of orbital floor fractures using either metal mesh or iliac bone transplant. In contrast to the metal mesh group, the iliac bone graft group did, however, exhibit a somewhat decreased incidence of diplopia and enophthalmos. Conclusion: In conclusion, metal mesh and iliac bone graft are both reliable methods for reconstructing the orbital floor, and their rates of surgical complications are similar. However, there could be little benefit to iliac bone grafting in terms of lower rates of enophthalmos and diplopia. Based on the preferences of the surgeon and patient-specific criteria, the procedure should be selected individually.

Evaluation of Cytotoxic Effects of Purified Mercury in Human Gingival Fibroblasts-In vitro Study.

Background: Since the introduction of amalgam for tooth fillings, there have been concerns that mercury toxicity could pose unacceptable health risks. Rasa shastra is an ancient medical discipline that focuses on the utilization of metals and minerals for the treatment of diseases. Nevertheless, these minerals cannot be directly administered to the human body in their natural state due to their potential adverse effects. Hence, for medicinal purposes, these metals and minerals need to undergo purification (Shodhana) to eliminate impurities and modify their physical, chemical, and biological characteristics. Methodology: Human gingival fibroblasts (HGF) were exposed to commercially available mercury (CA-Hg) and ayurvedically purified mercury (AP-Hg) at concentrations of 6.25 µM, 12.5 µM, 25 µM and 50 µM. The unexposed HGF cultured in basal media was considered a control. All the samples were cultured for 24 hours and 48 hours, and the cytotoxicity was analyzed by MTT assay. Results: Cell viability between the control and experimental groups varied at 24 hours, however, the results were not statistically significant (p>0.05). At 48 hours, cell viability was higher in the AP-Hg group as compared to the CA-Hg group at the concentration of 6.25 µM, and the difference was statistically significant (p<0.05). The cell proliferation assay results demonstrated a statistically significant difference in the mean optical density values (p<0.05) between CA-Hg and AP-Hg at 12.50 µM, 25 µM, and 50, µM concentrations observed at 24 hours. At 48 hours, a statistically significant difference in the mean OD values (p<0.05) between CA-Hg and AP-Hg at all four concentrations was observed. Conclusion: AP-Hg at a concentration of 6.25 µM demonstrated higher cell viability at 48 hours. Further, the cell proliferation rate was also higher for AP-Hg at all concentrations at 24 and 48 hours. These results indicated a less cytotoxic effect of AP-Hg than CA-Hg in HGF and hence could be employed for dental amalgam preparations.

Efficacy of a Four-Week Diagonal Pattern Exercise Program on Trunk and Lower Limb Function in Patients With Stroke-Induced Hemiplegia.

Objective The intended effect of this investigation is to quantify the efficacy of a four-week program of diagonal pattern exercises in managing trunk impairments and improving gait difficulties in hemiplegic stroke subjects. The study aims to measure changes in trunk stability and gait parameters post-intervention, providing insights into the potential therapeutic benefits of these exercises for stroke rehabilitation. Methodology This experimentation approach encompassing before and the follow-up test evaluations was implemented in this investigation. It was conducted at Madha College of Physiotherapy, Chennai, using convenience sampling to recruit 20 stroke subjects meeting specific inclusion criteria. Participants underwent pre-test evaluations for trunk control and gait. They were then divided equally into two groups for a four-week intervention comprising diagonal pattern exercises or single-plane training. Treatment sessions were administered five days per week for 45 minutes each. Posttest evaluations assessed changes in trunk control using the Trunk Impairment Scale (TIS) and gait parameters via the Timed Up and Go (TUG) test. Results Pretest analysis indicated no substantial baseline variations among the experimental and control groups, affirming their suitability for comparison. Posttest analysis of intervention at a 5% significance level revealed that the experimental group demonstrated a statistically significant improvement in trunk control, as measured by the TIS and TUG test, compared to the control group. The paired t-test results showed significant differences in pre- and posttest values within each group, while the unpaired t-test confirmed the superiority of the experimental group's outcomes, with a P-value < 0.05. This improvement is likely due to the effectiveness of the diagonal pattern exercise in enhancing trunk muscle activity and coordination. Conclusions This study concludes that diagonal pattern training is more beneficial for improving trunk musculature control and locomotory ability in chronic cerebrovascular accident subjects. The exercise program's simplicity, minimal risks, and ease of home application after initial therapist supervision make it a promising therapeutic approach.

Turbulent characteristics of momentum flux in the marine atmospheric boundary layer of North Bay of Bengal.

We use a 16-month-long, 20 Hz wind data from a mooring deployed in the Bay of Bengal (BoB) to study the characteristics of turbulent wind stress ( u ' w ' ) events in the marine atmospheric boundary layer (MABL). Quadrant analysis of the motion-corrected u ' and w ' suggests that sweep and ejections, representing downward stress transfer into the ocean, dominate the u ' w ' (~ 140%). In comparison, outward and inward interactions representing an upward stress transfer into the atmosphere provide the counter-contribution (~ 40%). We found a wind speed (ws) dependency on stress transfer for ws > 3 m/s, while for low ws, the swell-dominated ocean state modulates the u ' w ' with a significant reverse stress transfer into the atmosphere, especially during intermonsoon periods. It is found that for weak winds ( ws < 3 m/s), the number of turbulent events (N) is less, but they frequently repeat with more considerable flux per event ( f ^ ) , with outward and inward interactions (sweeps and ejections) dominating during intermonsoon periods (monsoon periods). For medium to strong winds, sweeps and ejections dominate u ' w ' . Ejections are found to be the most efficient method of stress transfer in the BoB, contributing 80% of u ' w ' , compared to sweeps contributing ~ 60% and interaction processes contributing ~ - 20% each to the u ' w ' . Though the duration of sweep events is larger than ejections and with comparable flux energy per event ( f ^ ), the larger number N of ejection events makes it the dominant stress transfer mechanism in the Bay in all seasons.

Isolating pathogenic multidrug-resistant Aeromonas hydrophila from diseased fish and assessing the effectiveness of a novel lytic Aeromonas veronii bacteriophage (AVP3) for biocontrol.

The increasing trend of antimicrobial resistance (AMR) pathogens in aquaculture makes it is imperative to find control measures for AMR pathogens causing high economic losses in aquaculture. In the present study, a multidrug resistance (MDR) Aeromonas hydrophila bacterium was isolated from kidney samples of diseased carp originating from a fish farm in Awankot, Rupnagar, Punjab, India. Moribund-infected fish exhibited large irregular hemorrhages on the external body surfaces, exophthalmia and fin-rot-like lesions. Phenotypic characterization using Rimler-Shotts (RS) media showed characteristic yellow color colonies and beta hemolysis on sheep blood agar. Genotyping using species-specific primers for the rpoB and gyrB genes characterized the isolate as A. hydrophila. The Multiple Antibiotic Resistance (MAR) index analysis showed that the isolated A. hydrophila had an MAR score of 0.29 signifying its resistance to more than three antibiotics, which underscores the need of finding treatment methods for MDR A. hydrophila isolates causing disease in aquaculture. Bacteriophages are considered a better eco-friendly alternative to antibiotics because of their inherent properties of not causing drug residues and resistance. Of the 13 phages tested, the Aeromonas veronii phage designated as AVP3, initially isolated against Aeromonas veronii, showed lytic activity against the MDR A. hydrophila isolated from diseased carp in this study. In addition, it also showed the lytic activity against Aeromonas spp. And A. caviae indicating that it had lytic properties against a wide host range within the Aeromonas species. This finding points to the potential efficacy of bacteriophages in mitigating pathogenic infections in aquaculture.

Design and implementation of a universal converter for microgrid applications using approximate dynamic programming and artificial neural networks.

This paper introduces a novel design for a universal DC-DC and DC-AC converter tailored for DC/AC microgrid applications using Approximate Dynamic Programming and Artificial Neural Networks (ADP-ANN). The proposed converter is engineered to operate efficiently with both low-power battery and single-phase AC supply, utilizing identical side terminals and switches for both chopper and inverter configurations. This innovation reduces component redundancy and enhances operational versatility. The converter's design emphasizes minimal switch usage while ensuring efficient conversion to meet diverse load requirements from battery or AC sources. A conceptual example illustrates the design's principles, and comprehensive analyses compare the converter's performance across various operational modes. A test bench model, rated at 3000W, demonstrates the converter's efficacy in all five operational modes with AC/DC inputs. Experimental results confirm the system's robustness and adaptability, leveraging ADP-ANN for optimal performance. The paper concludes by outlining potential applications, including microgrids, electric vehicles, and renewable energy systems, highlighting the converter's key advantages such as reduced complexity, increased efficiency, and broad applicability.

Enhancing Dynamic Balance and Postural Stability in Stroke Patients: The Impact of Immersive Virtual Reality Training.

Introduction Stroke is a major neurological event resulting from reduced or blocked blood flow to the brain, leading to significant morbidity. Immediate medical attention is essential to minimize brain damage and improve outcomes since it leads to many clinical deficits like locomotor impairment, instability in postural control, tonic alterations of the affected musculature, and an array of neurological dysfunctions if left unnoticed. Immersive virtual reality (VR) has emerged as a novel therapeutic tool in stroke rehabilitation, offering engaging and realistic environments for therapy. This study aims to evaluate the effectiveness of immersive VR training combined with functional gait exercises in improving dynamic balance and postural stability in stroke patients, compared to VR training alone. Methods This comparative study included 30 subjects from Madha Medical College and Hospital, Chennai, Tamil Nadu, India, divided into two groups. Group A (n=15) received immersive VR combined with functional gait exercises, while Group B (n=15) received immersive VR alone. Subjects were aged 40-60 years with stable blood pressure and a stroke duration of two weeks to six months. The study spanned 12 weeks, with 30-minute sessions on alternate days. Dynamic balance and postural stability were assessed using the Functional Gait Assessment (FGA) and Falls Efficacy Scale (FES). Pre-test and post-test scores were evaluated using parametric tests. Results Post-test mean values showed significant improvements in both groups. Group A demonstrated greater effectiveness, with lower FES scores (mean 36.66 ± 11.12) than Group B (mean 46.66 ± 9.75). FGA scores were higher in Group A (mean 28.00 ± 0.925) compared to Group B (mean 26.06 ± 1.66). Significant differences were observed in pre-test and post-test values within each group, supporting the hypothesis that combined VR and gait exercises offer superior rehabilitation outcomes. Conclusions Immersive VR combined with functional gait exercises significantly improves dynamic balance and postural stability in stroke patients compared to VR alone. This integrated approach can enhance motor function recovery, increase independence, and improve the quality of life. VR's capability to simulate real-life activities and provide immediate feedback allows for personalized rehabilitation programs. Further research is required to validate these findings and optimize VR-based rehabilitation protocols.

Natural light driven plastic leaching effects on carbon chemistry in the tropical coastal waters of eastern Arabian sea: An experimental study.

This study examined the effects of solar light driven plastic degradation on carbon chemistry in the coastal waters of eastern Arabian Sea along the west coast of India. The research was conducted through experimental incubations exposed to natural sunlight at multiple locations between December 2023-February 2024. Photodegradation induced a significant pH decrease (up to 0.38 ± 0.02) between controls and plastic incubations ranging from 8.17 ± 0.01 to 7.54 ± 0.02 with the highest variation in the Mumbai coast ranging from 8.13 ± 0.01 to 7.75 ± 0.03. pH variations are primarily caused by the leaching of organic acids and CO2 release during solar irradiated incubation. Plastic leaching due to natural light irradiation and subsequent changes in the water chemistry is of prime significance with dissolved organic carbon (DOC) leaching of 0.002-0.03% of plastic weight into the coastal waters. Our estimations suggest 15-75 metric tonnes (MT) of DOC release per year by plastic pollution in the eastern Arabian Sea coastal waters. Further, the fluorescent dissolved organic matter (FDOM) fragmentation, a part of DOC, may act as an organic source of synthetic contaminants and would promote heterotrophic microbial action in the coastal waters. Photodegradation of plastic and the interaction of natural DOC and plastic-derived DOC resulted in longer wavelengths FDOM, which may affect the penetration of photosynthetically active radiation in the water column, thereby impacting primary production. Finally, future research work focussing on the role of plastic pollution in coastal ocean acidification and vice-versa is essential and will be increasingly intense in the upcoming decades.

Noma Masquerading as Squamous Cell Carcinoma - A Case Report in an AIDS Patient.

Rationale: Cancrum oris, also known as noma, is a rare and rapidly progressing gangrenous infection affecting the oral cavity, commonly seen in malnourished children. We discuss the clinical presentation, diagnostic dilemma and management in a 54-year-old male human immunodeficiency virus-positive patient with oral ulceration clinically resembling squamous cell carcinoma (SCC). Patient Concerns: The patient had severe oral ulceration with pain and difficulty eating food. Diagnosis: Histopathological examination was misleading as it revealed features akin to early invasion of SCC. Immunohistochemistry findings were not in favour of SCC. Treatment: Antiretroviral therapy was started owing to the decreased CD4 cell count. Outcomes: Lesions began to show signs of healing on follow-up. Take-away Lessons: This case aims to highlight the unique challenges of diagnosing and emphasises the importance of considering opportunistic infections in immunocompromised patients presenting with oral ulcerations to prevent misdiagnosis and maltreatment.

Erratum to "Multi-trait stability index for identification of stable green gram (Vigna radiata (L.) Wilczek) genotypes with MYMV resistance" [Heliyon Volume 10, Issue 12, June 2024, Article e32763].

[This corrects the article DOI: 10.1016/j.heliyon.2024.e32763.].