The potential of MXene-based materials in fluorescence-based sensing/biosensing of ionic and organic contaminants in environment and food samples: Recent advancements and challenges.

MXenes belong to one of the recently developed advanced materials with tremendous potential for diverse sensing applications. To date, various types of MXene-based materials have been developed to generate direct/indirect ultrasensitive sensing signals against various forms of analytes via fluorescence quenching or enhancement. In this work, the fluorescence sensing/biosensing capabilities of the MXene-based materials have been explored and evaluated against a list of ionic/emerging pollutants in environment and food matrices. The suitability of an MXene-based sensing approach is also validated through the assessment of the performance based on the basic quality assurance parameters, e.g., limit of detection (LOD), sensing range, and response time. Accordingly, the best performing MXene-based materials are selected and recommended for the given target(s) to help facilitate their scalable applications under real-world conditions.

Nanomaterials-based aptasensors: An efficient detection tool for heavy-metal and metalloid ions in environmental and biological samples.

In light of potential risks of heavy metal exposure, diverse aptasensors have been developed through the combination of aptamers with nanomaterials for the timely and efficient detection of metals in environmental and biological matrices. Aptamer-based sensors can benefit from multiple merits such as heightened sensitivity, facile production, uncomplicated operation, exceptional specificity, enhanced stability, low immunogenicity, and cost-effectiveness. This review highlights the detection capabilities of nanomaterial-based aptasensors for heavy-metal and metalloid ions based on their performance in terms of the basic quality assurance parameters (e.g., limit of detection, linear dynamic range, and response time). Out of covered studies, dendrimer/CdTe@CdS QDs-based ECL aptasensor was found as the most sensitive option with an LOD of 2.0 aM (atto-molar: 10-18 M) detection for Hg2+. The existing challenges in the nanomaterial-based aptasensors and their scientific solutions are also discussed.

Advancements in nanomaterial-based aptasensors for the detection of emerging organic pollutants in environmental and biological samples.

The combination of nanomaterials (NMs) and aptamers into aptasensors enables highly specific and sensitive detection of diverse pollutants. The great potential of aptasensors is recognized for the detection of diverse emerging organic pollutants (EOPs) in different environmental and biological matrices. In addition to high sensitivity and selectivity, NM-based aptasensors have many other advantages such as portability, miniaturization, facile use, and affordability. This work showcases the recent advances achieved in the design and fabrication of NM-based aptasensors for monitoring EOPs (e.g., hormones, phenolic contaminants, pesticides, and pharmaceuticals). On the basis of their sensing mechanisms, the aptasensing systems can be classified as electrochemical, colorimetric, PEC, fluorescence, SERS, and ECL aptasensors. Special attention has been paid to the fabrication processes, analytical reliability, and sensing mechanisms of NM-based aptasensors. Further, the practical utility of aptasensing approaches has also been assessed based on their basic performance metrics (e.g., detection limits, sensing ranges, and response times).

Potential utility of BiOX photocatalysts and their design/modification strategies for the optimum reduction of CO2.

As an effective means to efficiently control the emissions of carbon dioxide (CO2), photo-conversion of CO2 into solar fuels (or their precursors) is meaningful both as an option to generate cleaner energy and to alleviate global warming. In this regard, bismuth oxyhalide (BiOX, where X = Cl, Br, and I) semiconductors have sparked considerable interest due to their multiple merits (e.g., visible light-harvesting, efficient charge carriers separation, and excellent chemical stability). In this review, the fundamental aspects of BiOX-based photocatalysts are discussed in relation to their modification strategies and associated reduction mechanisms of CO2 to help expand their applicabilities. In this context, their performance is also evaluated in terms of the key performance metrics (e.g., quantum efficiency (QE), space-time yield (STY), and figure of merit (FoM)). Accordingly, the morphology design of BiOX materials is turned out as one of the most efficient strategies for the maximum yield of CO while the introduction of heterojunctions into BiOX materials was more suitable for CH4 formation. As such, the adoption of the proper modification approach is recommended for efficient conversion of CO2.

Citrate and glutathione capped gold nanoparticles for electrochemical immunosensing of atrazine: Effect of conjugation chemistry.

Recently, the exposure of pesticides/herbicides to the living organisms is increased especially due to agricultural malpractices and industrial processes. In particular, the exposure of pesticides/herbicides (e.g., atrazine) can impart several harsh effects on the human health. The development of efficient detection systems can be crucial in monitoring the atrazine in water and food/plant products, which can be decisive in controlling the deadly exposures of atrazine. Herein, we have developed electrochemical immunosensors for atrazine by employing monoclonal anti-atrazine antibody conjugated gold nanoparticles. Two types of gold nanoparticles (i.e., citrate and glutathione (GSH)-capped AuNPs) were used to modify gold working electrode and utilized for the development of atrazine immunosensors. The conjugation of immunoprobe on working electrode was especially designed to obtain stable and efficient sensing signals. The nanosensing immunoprobes fabricated using citrate-AuNPs and GSH-AuNPs exhibited comparable responses for a wide linear working range of 50 ng/L- 30 µg/L with limit of detection (LOD) values of 0.08 and 0.06 ng/L for atrazine, respectively.

Use of molecular imprinted polymers as sensitive/selective luminescent sensing probes for pesticides/herbicides in water and food samples.

As non-biological molecules, molecular imprinted polymers (MIPs) can be made as antibody mimics for the development of luminescence sensors for various targets. The combination of MIPs with nanomaterials is further recognized as a useful option to improve the sensitivity of luminescence sensors. In this work, the recent progresses made in the fabrication of fluorescence, phosphorescence, chemiluminescence, and electrochemiluminescence sensors based on such combination have been reviewed with emphasis on the detection of pesticides/herbicides. Accordingly, the materials that are most feasible for the detection of such targets are recommended based on the MIP technologies.

Nanomaterial-based aptasensors as an efficient substitute for cardiovascular disease diagnosis: Future of smart biosensors.

As a major cause of deaths in developed countries, cardiovascular disease (CVD) has been a big burden for human health systems. Its early and rapid detection is crucial to efficiently apply appropriate on time therapy and to ultimately reduce the associated mortality rate. Aptamers, known as single-stranded DNA/RNA or oligonucleotides containing receptors and/or catalytic properties, have been widely employed in biodetection platforms due to their beneficial properties. Like antibodies, aptamers have served as artificial target receptors in affinity biosensors. Currently, advanced biosensors with improved sensitivity and specificity are fabricated by the synergistic combination of aptamers and diverse nanomaterials. Herein, we review the current development and applications of nanomaterial-based aptasensors for the recognition of CVD biomarkers with special emphasis on electrochemical and optical technologies. The performance of aptasensors has been assessed further in terms of key quality assurance metrics along with discussions on recent technologies developed for the amplification of signals with enhanced portability.

Influence of Fe(III) on the Fluorescence of Lysozyme: a Facile and Direct Method for Sensitive and Selective Sensing of Fe(III).

Lysozyme is widely used for the synthesis of nanomaterials (e.g., gold nanoparticle) to fluorescently sense metal ions. However, the effect of metal ions on the fluorescence of lysozyme is not studied yet. Herein, we have explored the interactions of lysozyme with different metal ions to develop a direct sensing platform for Fe(III). It has been observed that the fluorescence of lysozyme was slightly decreased in the presence of Cu(II), Hg(II), As(V), Co(II), Cd(II), Cr(II), Fe(II), Mn(II), Pb(II), and Zn(II), while a significant decrease in the lysozyme fluorescence was observed for Fe(III). The effect of thermal stability on the fluorescence quenching was also studied from 25 to 60 °C. In the present study, the lysozyme sensing probe was able to selectively and accurately detect 0.5-50 ppm of Fe(III) with a LOD of 0.1 ppm (1.8 µM) at 25 °C.

Aspects of Point-of-Care Diagnostics for Personalized Health Wellness.

Advancements in analytical diagnostic systems for point-of-care (POC) application have gained considerable attention because of their rapid operation at the site required to manage severe diseases, even in a personalized manner. The POC diagnostic devices offer easy operation, fast analytical outcome, and affordable cost, which promote their advanced research and versatile adoptability. Keeping advantages in view, considerable efforts are being made to design and develop smart sensing components such as miniaturized transduction, interdigitated electrodes-based sensing chips, selective detection at low level, portable packaging, and sustainable durability to promote POC diagnostics according to the needs of patient care. Such effective diagnostics systems are in demand, which creates the challenge to make them more efficient in every aspect to generate a desired bio-informatic needed for better health access and management. Keeping advantages and scope in view, this mini review focuses on practical scenarios associated with miniaturized analytical diagnostic devices at POC application for targeted disease diagnostics smartly and efficiently. Moreover, advancements in technologies, such as smartphone-based operation, paper-based sensing assays, and lab-on-a-chip (LOC) which made POC more sensitive, informative, and suitable for major infectious disease diagnosis, are the main focus here. Besides, POC diagnostics based on automated patient sample integration with a sensing platform is continuously improving therapeutics interventions against specific infectious disease. This review also discussed challenges associated with state-of-the-art technology along with future research opportunities to design and develop next generation POC diagnostic systems needed to manage infectious diseases in a personalized manner.

Recent progress in nanomaterial-based sensing of airborne viral and bacterial pathogens.

Airborne pathogens are small microbes that can cause a multitude of diseases (e.g., the common cold, flu, asthma, anthrax, tuberculosis, botulism, and pneumonia). As pathogens are transmitted from infected hosts via a number of routes (e.g., aerosolization, sneezing, and coughing), there is a great demand to accurately monitor their presence and behavior. Despite such need, conventional detection methods (e.g., colony counting, immunoassays, and various molecular techniques) generally suffer from a number of demerits (e.g., complex, time-consuming, and labor-intensive nature). To help overcome such limitations, nanomaterial-based biosensors have evolved as alternative candidates to realize portable, rapid, facile, and direct on-site identification of target microbes. In this review, nano-biosensors developed for the detection of airborne pathogens are listed and discussed in reference to conventional options. The prospects for the development of advanced nano-biosensors with enhanced accuracy and portability are also discussed.

A Novel Approach for Effective Alteration of Morphological Features of Polyaniline through Interfacial Polymerization for Versatile Applications.

Morphological characteristics of any nanomaterial are critical in defining its properties. In this context, a method to control morphological parameters of polyaniline (PANI) has been investigated by producing its composite with gold nanoparticles (AuNPs). Herein, we report for the first time the successful control on the physical/chemical properties of PANI composites synthesized via interfacial polymerization through functionalization of its AuNP composite component with citrate, ascorbate, glutathione (GSH), and cetyl trimethyl ammonium bromide (CTAB). A significant difference in the polymerization pattern, morphologies, and electrical properties was recognized in these composites according to the functionality of the modified AuNPs. The obtained composites of AuNPs/PANI exhibited highly diverse morphologies (e.g., nodule, hollow hemisphere, flake, and spider-web galaxy type) and electrical characteristics according to functionalization. Hence, this study is expected to offer better insight into control of the polymerization pattern of AuNP/PANI composites and their associated properties.

Recent advances in nanoscale materials for antibody-based cancer theranostics.

The quest for advanced management tools or options of various cancers has been on the rise to efficiently reduce their risks of mortality without the demerits of conventional treatments (e.g., undesirable side effects of the medications on non-target tissues, non-targeted distribution, slow clearance of the administered drugs, and the development of drug resistance over the duration of therapy). In this context, nanomaterials-antibody conjugates can offer numerous advantages in the development of cancer theranostics over conventional delivery systems (e.g., highly specific and enhanced biodistribution of the drug in targeted tissues, prolonged systemic circulation, low toxicity, and minimally invasive molecular imaging). This review comprehensively discusses and evaluates recent advances in the application of nanomaterial-antibody bioconjugates for cancer theranostics for the further advancement in the control of diverse cancerous diseases. Further, discussion is expanded to cover the various challenges and limitations associated with the design and development of nanomaterial-antibody conjugates applicable towards better management of cancer.

Experimental and Computational Study on the Selective Interaction of Functionalized Gold Nanoparticles with Metal Ions: Sensing Prospects.

Herein, we have developed citrate-, glutathione-, and ascorbate-functionalized gold nanoparticles (AuNPs) to examine their interactions with diverse heavy metal ions, such as Cd, Mn, Cr, Fe, Co, Pb, Hg, Zn, and Ti. These interactions are crucial in defining the final outcome of AuNP-based sensing/removal of heavy metals. We have evaluated these interactions by analyzing the variations in the color and spectroscopic signals of functionalized AuNPs. Additionally, the obtained results were also compared and validated with the computational studies. It has been observed that citrate-AuNPs and GSH-AuNPs displayed high selectivity toward Cr and Mn with Eforce values of -23.4 and -14.0 kJ/mol, respectively. Likewise, the ascorbate-AuNPs displayed sensitivity for multiple ions, for example, Cd, Fe, and Mn, with an Eforce value of -19.6 kJ/mol. A detailed analysis focusing on the electrostatic charges, ionic sizes, and interaction energy values has been provided to show specific interactions between functionalized AuNPs and heavy metal ions. The respective mechanisms of interaction between heavy metal ions and functionalized AuNPs have been explored with the help of experimental and computational outcomes.

Nanomaterial-based immunosensors for ultrasensitive detection of pesticides/herbicides: Current status and perspectives.

The increasing level of pesticides and herbicides in food and water sources is a growing threat to human health and the environment. The development of portable, sensitive, specific, simple, and cost-effective sensors is hence in high demand to avoid exposure or consumption of these chemicals through efficient monitoring of their levels in food as well as water samples. The use of nanomaterials (NMs) for the construction of an immunosensing system was demonstrated to be an efficient and effective option to realize selective sensing against pesticides/herbicides. The potential of such applications has hence been demonstrated for a variety of NMs including graphene, carbon nanotubes (CNTs), metal nanoparticles, and nano-polymers either in pristine or composite forms based on diverse sensing principles (e.g., electrochemical, optical, and quartz crystal microbalance (QCM)). This article evaluates the development, applicability, and performances of NM-based immunosensors for the measurement of pesticides and herbicides in water, food, and soil samples. The performance of all the surveyed sensors has been evaluated on the basis of key parameters, e.g., detection limit (DL), sensing range, and response time.

Highly stable AgNPs prepared via a novel green approach for catalytic and photocatalytic removal of biological and non-biological pollutants.

Increases in biological and non-biological pollutants pose a significant threat to environmental systems. In an effort to develop an effective means to treat such pollutants, the use of Phaseolus vulgaris (kidney beans) as reducing and capping agents is proposed for the green synthesis of highly stable silver nanoparticles (AgNPs) with a face-centered cubic (fcc) crystalline structure (size range: 10-20 nm). The potent role of the resulting AgNPs was found as triple platforms (photocatalyst, catalyst, and antimicrobial disinfectant). AgNPs were able to photocatalytically degrade approximately 97% of reactive red-141 (RR-141) dye within 150 min of exposure (quantum efficiency of 3.68 × 10-6 molecule.photon-1 and a removal reaction kinetic rate of 1.13 × 10-2 mmol g-1 h-1). The role of specific reactive oxygen species (ROS) in the photocatalytic process and complete mineralization of dye was also explored through scavenger and chemical oxygen demand (COD) experiments, respectively. As an catalyst, AgNPs were also capable of reducing 4-nitrophenol to 4-aminophenol within 15 min. Overall, AgNPs showed excellent stability as catalyst and photocatalyst even after five test cycles. As an antimicrobial agent, the AgNPs are effective against both gram-positive (Bacillus subtilis) and -negative bacteria (Escherichia coli), with the zones of clearance as 15 and 18 mm, respectively. Thus, the results of this study validate the triple role of AgNPs derived via green synthesis as a photocatalyst, catalyst, and antimicrobial agent for effective environmental remediation.

Utilization of metal-organic frameworks for the adsorptive removal of an aliphatic aldehyde mixture in the gas phase.

Considerable efforts have been undertaken in the domain of air quality management for the removal of hazardous volatile organic compounds, particularly carbonyl compounds (CCs). In this study, the competitive sorptive removal of six CCs (namely, formaldehyde, acetaldehyde, propionaldehyde, butyraldehyde, isovaleraldehyde, and valeraldehyde) was assessed using selected metal-organic frameworks (MOFs: MOF-5, MOF-199, UiO-66, and UiO-66-NH2) and inexpensive commercial activated carbon as a reference sorbent. The sorption experiments were conducted using a mixture of the six CCs (formaldehyde and acetaldehyde at ∼1 Pa and propionaldehyde, butyraldehyde, isovaleraldehyde, and valeraldehyde at ∼0.2 Pa) together with 15 Pa water and 2.6 Pa methanol in 1 bar nitrogen. For all of the carbonyl compounds other than formaldehyde, MOF-199 showed the best 10% breakthrough performance ranging from 34 L g-1 and 0.14 mol kg-1 Pa-1 for acetaldehyde to 1870 L g-1 and 7.6 mol kg-1 Pa-1 for isovaleraldehyde. Among all the sorbents tested, UiO-66-NH2 exhibited the best 10% breakthrough performance metrics towards the lightest formaldehyde which remains to be one of the most difficult targets for sorptive removal (breakthrough volume: 285 L g-1 and partition coefficient: 1.1 mol kg-1 Pa-1). Theoretical density functional theory (DFT)-based computations were also conducted to provide better insights into the adsorbate-adsorbent interactions. Accordingly, the magnitude of adsorption energy increased with an increase in the CC molar mass due to an enhancement in the synergetic interaction between C[double bond, length as m-dash]O groups (in adsorbate molecules) and the MOF active centers (open metallic centers and/or NH2 functionality) as the adsorbent. Such interactions were observed to result in strong distortion of MOF structures. In contrast, weak van der Waals attraction between the hydrocarbon "tail" of CC molecules and MOF linkers were seen to play a stabilizing role for the sorbent structure. The presence of the NH2 group in the MOF structure was suspected to play a key role in capturing lighter CCs, while such an effect was less prominent for heavier CCs. Overall, the results of this study provided a basis for the establishment of an effective strategy to enhance the sorption capacity of MOFs against diverse carbonyl species.

Recent advances in carbon nanotube sponge-based sorption technologies for mitigation of marine oil spills.

HYPOTHESIS: Oil spills stemming from supertankers, drilling, and natural events represent a serious problem worldwide due to the potential harms to marine ecosystems and aquatic life. To date, various functional absorbents have been developed to treat spilled oil. Among them, carbon nanotube (CNT)-based aerogels and sponges gained attention due to superior performance in uptake and recovery of various types of oil and organic solvents. CNT aerogel/sponge absorbents are demonstrated for a multitude of merits such as: rapid superhydrophobic/superoleophilic absorption (water contact angle > 150°), high capacity (≥100 mg g-1), large surface area (300-400 m2 g-1)), enhanced strength and flexibility (>95% volume reduction and restoration of pristine morphology at <0.25 MPa stress), mesoporous characteristics with high pore density (pore diameter = 80 nm and >99% porosity), recyclability, and easy surface modification. EXPERIMENTS: This review compares CNT sponge-based absorbents with conventional techniques for remediation/recovery of spilled oil. Typically, synthesis of CNT sponges is performed using chemical vapor deposition (CVD) approach in the presence of a catalyst or using sacrificial removal of template. This work summarizes recent progress in strategies for oil-spill treatment based on CNT sponge techniques. The performance of CNT sponges for oil spill removal was evaluated in terms of their adsorption capacity, compressive stressability, and desorption methods (e.g., heat treatment, burning, or squeezing). FINDINGS: CNT sponges were observed to have high performance for removal of oil spills in terms of key performance metrics. This review offers valuable insights into the current state of CNT-mediated oil-spill cleanup technologies and guidance for future research at the same time. This literature survey would help the stakeholders (researchers, scientists, entrepreneurs, and commercial houses) pursue contamination-free water.

Role of gold nanoparticles in advanced biomedical applications.

Gold nanoparticles (GNPs) have generated keen interest among researchers in recent years due to their excellent physicochemical properties. In general, GNPs are biocompatible, amenable to desired functionalization, non-corroding, and exhibit size and shape dependent optical and electronic properties. These excellent properties of GNPs exhibit their tremendous potential for use in diverse biomedical applications. Herein, we have evaluated the recent advancements of GNPs to highlight their exceptional potential in the biomedical field. Special focus has been given to emerging biomedical applications including bio-imaging, site specific drug/gene delivery, nano-sensing, diagnostics, photon induced therapeutics, and theranostics. We have also elaborated on the basics, presented a historical preview, and discussed the synthesis strategies, functionalization methods, stabilization techniques, and key properties of GNPs. Lastly, we have concluded this article with key findings and unaddressed challenges. Overall, this review is a complete package to understand the importance and achievements of GNPs in the biomedical field.

Potential applications of graphene-based nanomaterials as adsorbent for removal of volatile organic compounds.

In recent years, graphene-based materials (GBMs) have been regarded as the core technology in diverse research fields. Consequently, the demand for large-scale synthesis of GBMs has been increasing continuously for various fields of industry. These materials have become a competitive adsorbent for the removal of environmental pollutants with improved adsorption capacity and cost effectiveness through hybridization or fabrication of various functionalities on their large surface. In particular, their applicability opens up new avenues for the adsorptive removal of volatile organic compounds (VOCs) (e.g., through the build-up of efficient air purification systems). This review explored the basic knowledge and synthesis approaches for GBMs and their performances as adsorbent for VOC removal. Moreover, the mechanisms associated with the VOC removal were explained in detail. The performance of GBMs has also been evaluated along with their present limitations and future perspectives.

A review of functional sorbents for adsorptive removal of arsenic ions in aqueous systems.

The presence of arsenic in the water system has been a universal problem over the past several decades. Inorganic arsenic ions mainly occur in two oxidation states, As(V) and As(III), in the natural environment. These two oxidation states of arsenic ions are ubiquitous in natural waters and pose significant health hazards to humans when present at or above the allowable limits. Therefore, treatment of arsenic ions has become more stringent based on various techniques (e.g., membrane filtration, adsorption, and ion exchange). This paper aims to review the current knowledge on various functional adsorbents through comparison of removal potential for As on the basis of key performance metrics, especially the partition coefficient (PC). As a whole, novel materials exhibited far better removal performance for As(V) and As(III) than conventional materials. Of the materials reviewed, the advanced sorbent like ZrO(OH)2/CNTs showcased superior performances such as partition coefficient values of 584.6 (As(V) and 143.8 mol kg-1 M-1 (As(III) with excellent regenerability (>90 % of desorption efficiency after three sorption cycles). The results of this review are expected to help researchers to establish a powerful strategy for abatement of arsenic ions in wastewater.