1.
Bioorg Med Chem Lett
; 12(19): 2757-60, 2002 Oct 07.
Article
in English
| MEDLINE
| ID: mdl-12217370
ABSTRACT
The synthesis and biological activity of sordarin oxazepine derivatives are described. The key step features a regioselective oxidation of an unprotected triol followed by double reductive amination to afford the ring-closed products. The spectrum of antifungal activity for these novel derivatives includes coverage of Candida albicans, Candida glabrata, and Cryptococcus neoformans.