Subject(s)
Intracranial Thrombosis/genetics , Janus Kinase 2/genetics , Mutation , Myeloproliferative Disorders/genetics , Venous Thrombosis/genetics , Aged , Female , Genetic Predisposition to Disease , Humans , Intracranial Thrombosis/diagnosis , Intracranial Thrombosis/enzymology , Intracranial Thrombosis/therapy , Male , Middle Aged , Myeloproliferative Disorders/complications , Myeloproliferative Disorders/diagnosis , Myeloproliferative Disorders/enzymology , Myeloproliferative Disorders/therapy , Phenotype , Risk Factors , Treatment Outcome , Venous Thrombosis/diagnosis , Venous Thrombosis/enzymology , Venous Thrombosis/therapyABSTRACT
INTRODUCTION: Skin cancer occurs more readily in more aggressive forms in immunodepressed subjects. We report the case of a patient with chronic lymphoid leukaemia and multiple skin carcinomas complicated with carcinomatous lymphangitis. CASE REPORT: A 63 year-old man with chronic lymphoid leukaemia, stage A in the Binet classification, had multiple epidermoid carcinomas on the trunk and face. The skin tumours were complicated with cervical lymph mode metastases, then a prethoracic carcinomatous lymphangitis with a rapidly fatal clinical course. DISCUSSION: Chronic lymphoid leukaemia and lymphomas are associated with a high incidence of skin carcinoma. The immunodepression inherent in the haematologic disease would appear to favor aggressive skin cancers. Our case was particularly severe since the carcinomatous lymphangitis was rapidly fatal.