ABSTRACT
Neonatal Encephalopathy (NE) is a neurologic syndrome in term and near-term infants who have depressed consciousness, difficulty initiating and maintaining respiration, and often abnormal tone, reflexes and neonatal seizures in varying combinations. Moderate/severe NE affects 0.5-3/1000 live births in high-income countries, more in low- and middle-income countries, and carries high risk of mortality or disability, including cerebral palsy. Reduced blood flow and/or oxygenation around the time of birth, as with ruptured uterus, placental abruption or umbilical cord prolapse can cause NE. This subset of NE, with accompanying low Apgar scores and acidemia, is termed Hypoxic-Ischemic Encephalopathy. Other causes of NE that can present similarly, include infections, inflammation, toxins, metabolic disease, stroke, placental disease, and genetic disorders. Aberrant fetal growth and congenital anomalies are strongly associated with NE, suggesting a major role for maldevelopment. As new tools for differential diagnosis emerge, their application for prevention, individualized treatment and prognostication will require further systematic studies of etiology of NE.
Subject(s)
Acidosis , Asphyxia Neonatorum , Hypoxia-Ischemia, Brain , Female , Humans , Hypoxia-Ischemia, Brain/complications , Hypoxia-Ischemia, Brain/epidemiology , Infant , Infant, Newborn , Placenta , Pregnancy , Seizures/etiologyABSTRACT
Phaeohyphomycosis is an increasingly recognized cause of brain abscess in both immunocompetent and immunocompromised hosts. We report a case of cerebral phaeohyphomycosis in a 55-year-old male heart transplant recipient caused by Bipolaris spicifera. We review the literature regarding the pathogenesis, epidemiology, diagnosis, and management of infections with dematiaceous fungi.
Subject(s)
Ascomycota/isolation & purification , Brain Abscess/microbiology , Cerebral Phaeohyphomycosis/microbiology , Heart Transplantation/adverse effects , Mycoses/microbiology , Antifungal Agents/therapeutic use , Ascomycota/classification , Ascomycota/drug effects , Brain Abscess/diagnostic imaging , Brain Abscess/drug therapy , Cerebral Phaeohyphomycosis/diagnostic imaging , Cerebral Phaeohyphomycosis/drug therapy , Humans , Immunocompromised Host , Magnetic Resonance Imaging , Male , Middle Aged , Mycoses/diagnostic imaging , Mycoses/drug therapy , Pyrimidines/therapeutic use , Radiography , Treatment Outcome , Triazoles/therapeutic use , VoriconazoleABSTRACT
AIMS: Periventricular white matter injury in premature infants occurs following hypoxia/ischaemia and systemic infection, and results in hypomyelination, as well as neuromotor and cognitive deficits later in life. Inflammatory infiltrates are seen within human cerebral white matter from periventricular leucomalacia (PVL) cases. METHODS: In this study, we examine the time course of CD-68+ microglial cell responses relative to cell death within white matter following hypoxia/ischaemia in a rat model of PVL. We also tested the efficacy of the minocycline, an agent that suppresses microglial activation, in this model when administered as a post-insult treatment. RESULTS: We show that preoligodendrocyte injury in the post-natal day 6 begins within 24 h and continues for 48-96 h after hypoxia/ischaemia, and that microglial responses occur primarily over the first 96 h following hypoxia/ischaemia. Minocycline treatment over this 96 h time window following the insult resulted in significant protection against white matter injury, and this effect was concomitant with a reduction in CD-68+ microglial cell numbers. CONCLUSIONS: These results suggest that anti-inflammatory treatments may represent a useful strategy in the treatment of PVL, where clinical conditions would favour a post-insult treatment strategy.