Characterization of a human monocyte antigen, B148.4, regulated during cell differentiation and activation.

We analyzed the phenotypic changes associated with monocyte activation and differentiation using a newly developed monoclonal antibody (B148.4). Among peripheral blood leukocytes, the antigen recognized by this antibody is expressed on monocytes and granulocytes at high and low density, respectively. Antigen expression is lost during in vitro differentiation of monocytes and is absent on tissue macrophages, indicating that expression of this antigen is related to monocyte differentiation. Only 1 alpha,25-dihydroxyvitamin D3 and phorbol diesters, of several inducers tested, up-regulate B148.4 antigen expression on cells (monocytes and certain myeloid cell lines) that constitutively bear the antigen, without, however, allowing its maintenance during monocytic differentiation or inducing it on negative cells. By immunoprecipitation from B148.4+ U937 cells, the antigen is a complex of a major 116-kd and two minor 38- and 46-kd molecules. Analysis of eight different tissues reveals that the antigen is shared with endothelial cells. Biochemical characteristics, cellular distribution, and expression pattern on monocytes, myeloid cell lines, and AML cells upon culture with different stimuli indicate that B148.4 is a novel monocyte differentiation antigen.

[Bacillary peliosis in AIDS. Anatomo-clinical study of 2 cases]. / Péliose bacillaire au cours du SIDA. Etude anatomo-clinique de 2 observations.

The authors report two cases of peliosis hepatis, occurring in patients with AIDS, who presented a persistent fever and an hepatomegaly. The liver biopsies showed areas of peliosis, where bacilli were observed by Warthin-Starry stain. In one case, techniques of molecular biology allowed the identification of Rochalimaea henselae, pathogen involved in bacillary angiomatosis. This rickettsia has been newly recognized in the United-States, where 17 cases of bacillary peliosis have been published in immunocompromised hosts and mainly in patients with AIDS. These observations illustrate the clinical and histological features of this new opportunistic infection, as it is described in the literature. The clinical signs include an unexplained fever, an hepatomegaly, and in 75% of the cases, a splenomegaly. The cutaneous lesions of bacillary angiomatosis are associated in 40% of the cases. An antibiotic treatment by erythromycin ensures a complete recovery.

[Nephroblastomatosis and Wilms' tumor. Apropos of a case]. / Néphroblastomatose et tumeur de Wilms. A propos d'une observation.

This case report illustrates the different anatomopathologic patterns and evolutive potentials of perilobar nephroblastomatosis described by Beckwith. The latter differs from those of an intralobar nephroblastomatosis. The evolutive possibilities of nephroblastomatosis underline the importance of imaging technology in the diagnosis and control of such lesions, as well as the role of chemotherapy and above all the caution required in the indications for surgery.

[Inflammatory pseudo-tumors of the liver. Apropos of 2 cases]. / Les pseudo-tumeurs inflammatoires du foie. A propos de deux cas.

Inflammatory pseudotumors of the liver (IPTL) are a reaction pathology of most often mysterious etiology. This is an ill-known clinicopathological entity, of which 13 cases only have been reported. The authors report about 2 cases for which an infectious or parasitic etiology can be suggested. They sum up the characteristics of these pseudotumors, which are most often single, solid, preferentially developing in the right liver. The clinical signs of these lesions are pain and fever, associated to jaundice in case of pedicular extension. From a morphological and macroscopic point of view, IPTLs have the features of a primary or secondary malignant tumor. Cytological puncture usually fails. The diagnosis can be based only on an extensive surgical biopsy or the study of the specimen of liver exeresis. Finally, IPTLs are characterized by a spontaneously regressive evolution. This notion justifies a prudent, even conservative surgical attitude.

[Borderline lesions of the breast: clinical and radiological study of 20 cases]. / Les lésions frontières du sein: étude clinique et radiologique de 20 cas.

We describe the clinical and mammographic signs observed in 20 patients with atypical hyperplasia of the breast. The clinical signs include abnormalities noted at palpation (tumefaction, masses, clusters of nodules) and nipple discharge. The mammographic signs include rounded, clearly delineated opacities with benign appearances, or spiculated masses possibly associated with microcalcifications, stellate opacities, and isolated foci of microcalcifications. Galactography may visualize milk ducts dilatation. Both the clinical and mammographic signs are non-specific and even equivocal and do not allow pre-operative diagnosis of non-specific lesions.

[Epithelioid sarcoma. Apropos of 2 cases. Immunohistochemical study and review of the literature]. / Sarcome épithélioïde. A propos de deux observations. Etude immuno-histochimique et revue de la littérature.

We report two cases of epithelioid sarcoma (ES), including one with a 32-year follow-up. Difficult diagnostic problems often arise in this infrequent form of soft tissue sarcoma that predominantly involves the extremities and usually affects young individuals. Immunohistochemistry cannot elucidate histogenesis but does provide helpful information for the differential diagnosis.

[Muco-epidermoid cancer of the esophagus. Review of the literature. Report of a case with 9 years' follow-up]. / Les cancers muco-épidermoïdes de l'oesophage. Revue de la littérature. Rapport d'un cas avec recul de neuf ans.

Mucoepidermoid carcinoma of esophagus is a distinctly uncommon neoplasm. Diagnosis depends on precise microscopic criteria. Microscopic features should show distinct epidermoid features with evidence of intracellular mucus secretion. Their origin is generally believed to be esophageal submucosal glands or their ducts. In a survey of the literature, only 15 cases were found to have been reported. A case of a 43 year old man with a 9 year follow-up is presented. Prognosis of mucoepidermoid carcinoma is the same as ordinary squamous cell carcinoma of the esophagus.

[Diffuse esophageal leiomyomatosis. Apropos of 5 cases with 2 familial cases]. / La leiomyomatose oesophagienne diffuse. A propos de 5 observations dont 2 cas familiaux.

Diffuse esophageal leiomyomatosis is characterized by diffuse muscular hypertrophy chiefly marked in the lower end of the esophagus looks at a large tumor. It involves the entire length of the esophagus and down to the upper part of the stomach (esogastric leiomyomatosis). Diffuse leiomyomatosis is a extremely rare pathology encountered in children (13 previous report cases) and young adults. Il may be isolated or found in association with other intrathoracic and genital localisations or Alport syndrome (nephropathy, sensorineural deafness, ocular lesions). Extensive leiomyomatosis, engulfing the trachea and stem bronchi, may involve acute respiratory insufficiency. Genital localisations, exclusively in women (clitoral hypertrophy, vulvar leiomyomatosis), in association with esophageal leiomyomatosis, realize the esophago vulvar syndrome. Recently, familial diffuse leiomyomatosis cases were described with, in association, esophageal and extra-esophageal leiomyomatosis and Alport syndrome. The majority of the patients developed esophageal or respiratory symptoms. The radiological appearance is that of a mediastinal tumor or achalasia. CT Scans findings can give evidence diffuse muscular thickening of esophageal wall. Prognosis depends on the associated lesions. In that reports, two young adults (27 and 39 years old) died of inhabitual carcinomas (esophageal and gallbladder carcinoma). The only surgical treatment for symptomatic esogastric leiomyomatosis is subtotal esophagectomy with proximal gastrectomy and esocoloplasty. Myotomy is ineffective (2 cases). Five cases of esophageal leiomyomatosis are described (3 children, 2 young adults). Among these, two are familial leiomyomatosis cases. An esophageal resection was performed in four patients.

[Aneurysmal cyst of the petrous bone. Apropos of a case]. / Le kyste anévrismal du rocher. A propos d'une observation.

Aneurysmal bone cyst (ABC) is a rare form of osseous dystrophy. A lesion of the petrous temporal bone appears to be extremely rare. It must be differentiated from a hemangioma which is a hamartoma affecting the geniculate ganglion or the internal auditory meatus. The case described involved a 23-year-old woman. The ABC presented with violent otalgia and severe endolabyrinthic-type perception deafness. It was associated with extensive bony destruction of the petrous temporal and occipital bones. Curettage only led to considerable through temporary regression of deafness and bone reconstruction within a few months. Thrombosis of the internal jugular, confirmed at operation, is an interesting contribution in terms of the pathogenesis of ABC, apparently linked to disturbances of venous pressure. Surveillance is required since this benign condition may be recur.

[Lateral cysts and fistulae of the neck. Apropos 70 cases]. / Kystes et fistules latéraux du cou. A propos de 70 cas.

Anomalies of branchial origin, amygdaloid cysts and fistulae of 1st, 2nd and 3rd slits are not rare cervical affections. Their histology is characteristic: cylindrical epithelium for fistulae and malpighian epithelium with lymphoid masses for cysts. Excision must be completed by an approach route that is sufficiently wide to avoid recurrence and vascular-neural lesions of the neck.

[Osteomedullary amyloidosis with osteolytic lesions. Apropos of 4 cases]. / Amylose ostéomédullaire avec lésions ostéolytiques. A propos de 4 observations.

Amyloidosis of bone and bone marrow is rarely symptomatic and is generally limited to deposits diagnosed by histological examination. Four cases with lytic bone lesions are reported. In 2 cases, amyloidosis was associated with Waldenstroem's Macroglobulinemia, in one case with multiple myeloma and in 1 case with solitary plasmocytoma. These 4 cases are compared to 14 cases already published in the literature, including 2 cases of plasmocytic dyscrasias. The role of amyloidosis in the genesis of bone lesions is discussed.

[Angiolymphoid hyperplasia with eosinophilia or Kimura's disease]. / L'hyperplasie angiolymphoïde avec éosinophilie ou maladie de Kimura.

A rare affection of unknown etiology that is benign but frequently recurrent, Kimura's disease involves infiltration of the dermis and hypodermis usually of the face. Documented data exists describing clinical findings and results of histopathology that are analogous but are grouped under other names: angiolymphoid hyperplasia with eosinophilia, pyogenic pseudogranuloma, atypical pyogenic granuloma. A case followed up for 13 years is reported.