Involvement of SIRT1-mediated cellular immune response in cancer.

The morbidity and mortality of cancer are rising rapidly worldwide and immunotherapy has become an effective means to curb the progress of cancer. Sirtuin-1(SIRT1) is a NAD+ -dependent deacetylase that plays a key role in cancer development and immune regulation through mediating a variety of signaling pathways. Targeting SIRT1 in immunotherapy could enhance or erod immune responses against cancer cells, while SIRT1 activator and inhibitors are being developed as potential antineoplastic agents with important implications in clinic. This review summarizes the impact of SIRT1 in different types of immune cells and mechanism of SIRT1-mediated immune responses in tumor progression as well as its therapeutic perspectives.

Bifunctional Janus Membranes for Multicomponent Contaminated Seawater Separation and Recovery.

Solar-driven interface desalination has emerged as a promising strategy to address the global freshwater shortage crisis. However, the separation and recovery of multicomponent oil-contaminated seawater remain a key challenge. This study reports a novel high-strength Janus photothermal membrane with a unique reverse wettability design. On one side, the membrane has hydrophilic and oleophobic properties, while on the other, it has hydrophobic and oleophilic characteristics. The Janus membrane demonstrates dual functionality: solar desalination and oil-water separation. This dual functionality enables efficient separation and recovery of four components from contaminated seawater: purified water, salt crystals, light oil, and heavy oil. As a result, the Janus membrane achieves an evaporation rate of 2.06 kg m-2 h-1 under 1.0 sun. The ion (Na+, K+, Ca2+, and Mg2+) removal rate approaches 100% with nearly complete recovery of salt crystals. Furthermore, various types of oils can be accurately separated, with separation efficiency approaching 100%. An integrated separation device successfully separates and recovers the four components. This research presents significant potential for efficient separation and recovery of complex components in oil-contaminated seawater.

Helical Micropillar Processed by One-Step 3D Printing for Solar Thermal Conversion.

Solar thermal utilization has broad applications in a variety of fields. Currently, maximizing the photo-thermal conversion efficiency remains a research hotspot in this field. The exquisite plant structures in nature have greatly inspired human structural design across many domains. In this work, inspired by the photosynthesis of helical grass, a HM type solar absorber made in graphene-based composite sheets is used for solar thermal conversion. The unique design promoted more effective solar energy into thermal energy through multiple reflections and scattering of solar photons. Notably, the Helical Micropillar (HM) is fabricated using a one-step projection 3D printing process based on a special 3D helical beam. As a result, the solar absorber's absorbance value can reach 0.83 in the 400-2500 nm range, and the surface temperature increased by ≈128.3% relative to the original temperature. The temperature rise rate of the solar absorber reached 22.4 °C min-1, demonstrating the significant potential of the HM in practical applications of solar thermal energy collection and utilization.

Wide-Size Range and High Robustness Self-Assembly Micropillars for Capturing Microspheres.

Capillary force driven self-assembly micropillars (CFSA-MP) holds immense promise for the manipulation and capture of cells/tiny objects, which has great demands of wide size range and high robustness. Here, we propose a novel method to fabricate size-adjustable and highly robust CFSA-MP that can achieve wide size range and high stability to capture microspheres. First, we fabricate a microholes template with an adjustable aspect ratio using the spatial-temporal shaping femtosecond laser double-pulse Bessel beam-assisted chemical etching technique, and then the micropillars with adjustable aspect ratio are demolded by polydimethylsiloxane (PDMS). We fully demonstrated the advantages of the Bessel optical field by using the spatial-temporal shaping femtosecond laser double-pulse Bessel beams to broaden the height range of the micropillars, which in turn expands the size range of the captured microspheres, and finally achieving a wide range of capturing microspheres with a diameter of 5-410 µm. Based on the inverted mold technology, the PDMS micropillars have ultrahigh mechanical robustness, which greatly improves the durability. CFSA-MP has the ability to capture tiny objects with wide range and high stability, which indicates great potential applications in the fields of chemistry, biomedicine, and microfluidics.

Optoelectronically navigated nano-kirigami microrotors.

With the rapid development of micro/nanofabrication technologies, the concept of transformable kirigami has been applied for device fabrication in the microscopic world. However, most nano-kirigami structures and devices were typically fabricated or transformed at fixed positions and restricted to limited mechanical motion along a single axis due to their small sizes, which significantly limits their functionalities and applications. Here, we demonstrate the precise shaping and position control of nano-kirigami microrotors. Metallic microrotors with size of ~10 micrometers were deliberately released from the substrates and readily manipulated through the multimode actuation with controllable speed and direction using an advanced optoelectronic tweezers technique. The underlying mechanisms of versatile interactions between the microrotors and electric field are uncovered by theoretical modeling and systematic analysis. This work reports a novel methodology to fabricate and manipulate micro/nanorotors with well-designed and sophisticated kirigami morphologies, providing new solutions for future advanced optoelectronic micro/nanomachinery.

Spatial Writing of Ultrafast All-Optical Switching.

Writing spatial information on ultrafast all-optical switching is essential for constructing ultrafast processing units in photonic applications, such as optical communication and computing networks. However, most methods ignore the fabrication and imaging of controllable switching area, limiting its spatial information and the further design in ultrafast devices. Here, we propose a method to spatially write in ultrafast all-optical switching based on MAPbI3 perovskite with nanocone structure and visualize the switching effect in arbitrary designed area. Due to the light confinement effect of nanocone fabrication using a fs laser, the light is strongly absorbed by perovskite and reach saturable absorption. It leads to ultrafast broadband transmittance change with 25 fs switching time and 10% modulation depth in nanocone perovskite area. Our preparation method offers high efficiency, performance, and flexibility for the spatial writing of ultrafast all-optical switching, which is promising for developing ultrafast all-optical networks and the next generation of communication technology.

Regulation of Hot Electrons Transport Achieved through Controlled Electron-Phonon Coupling in Metallic Heterostructures.

The electron-phonon (e-ph) interactions are pivotal in shaping the electrical and thermal properties, and in particular, determining the carrier dynamics and transport behaviors in optoelectronic devices. By employing pump-probe spectroscopy and ultrafast microscopy, the consequential role of e-ph coupling strength in the spatiotemporal evolution of hot electrons is elucidated. Thermal transport across the metallic interface is controlled to regulate effective e-ph coupling factor Geff in Au and Au/Cr heterostructure, and their impact on nonequilibrium transport of hot electrons is examined. Via the modulation of buried Cr thickness, a strong correlation between Geff and the diffusive behavior of hot electrons is found. By enhancing Geff through the regulation of thermal transport across interface, there is a significant reduction in e-ph thermalization time, the maximum diffusion length of hot electrons, and lattice heated area which are extracted from the spatiotemporal evolution profiles. Therefore, the increased Geff significantly weakens the diffusion of hot electrons and promotes heat relaxation of electron subsystems in both time and space. These insights propose a robust framework for spatiotemporal investigations of G impact on hot electron diffusion, underscoring its significance in the rational design of advanced optoelectronic devices with high efficiency.

Key Role of Asymmetric Photothermal Effect in Selectively Chiral Switching of Plasmonic Dimer Driven by Circularly Polarized Light.

Strong interaction between circularly polarized light and chiral plasmonic nanostructures can enable controllable asymmetric photophysical processes, such as selective chiral switching of a plasmonic nanorod-dimer. Here, we uncover the underlying physics that governs this chiral switching by theoretically investigating the interplay between asymmetric photothermal and optomechanical effects. We find that the photothermally induced local temperature rises could play a key role in activating the dynamic chiral configurations of a plasmonic dimer due to the temperature-sensitive molecular linkages located at the gap region. Importantly, different temperature rises caused by the opposite handedness of light could facilitate selective chiral switching of the plasmonic dimer driven by asymmetric optical torques. Our analyses on the wavelength-dependent selectively chiral switching behaviors are in good agreement with the experimental observations. This work contributes to a comprehensive understanding of the physical mechanism involved in the experimentally designed photoresponsive plasmonic nanosystems for practical applications.

Thermal Emission Manipulation Enabled by Nano-Kirigami Structures.

The nano-kirigami metasurfaces have controllable 3D geometric parameters and dynamic transformation functions and therefore provide a strong spectral regulation capability of thermal emission. Here, the authors propose and demonstrate a dynamic and multifunctional thermal emitter based on deformable nano-kirigami structures, which can be actuated by electronic bias or mechanical compression. Selective emittance and the variation of radiation intensity/wavelength are achieved by adjusting the geometric shape and the transformation of the structures. Particularly, a thermal management device based on a composite structure of nano-kirigami and polydimethylsiloxane (PDMS) thin film is developed, which can dynamically switch the state of cooling and heating by simply pressing the device. The proposed thermal emitter designs with strong regulation capability and multiple dynamic adjustment strategies are desirable for energy and sensing applications and inspire further development of infrared emitters.

3D printing of plasmonic nanofocusing tip enabling high resolution, high throughput and high contrast optical near-field imaging.

Scanning near-field optical microscopy (SNOM) offers a means to reach a fine spatial resolution down to ~ 10 nm, but unfortunately suffers from low transmission efficiency of optical signal. Here we present design and 3D printing of a fiber-bound polymer-core/gold-shell spiral-grating conical tip that allows for coupling the inner incident optical signal to the outer surface plasmon polariton with high efficiency, which then adiabatically transport, squeeze, and interfere constructively at the tip apex to form a plasmonic superfocusing spot with tiny size and high brightness. Numerical simulations and optical measurements show that this specially designed and fabricated tip has 10% transmission efficiency, ~ 5 nm spatial resolution, 20 dB signal-to-noise ratio, and 7000 pixels per second fast scanning speed. This high-resolution, high throughput, and high contrast SNOM would open up a new frontier of high spatial-temporal resolution detecting, imaging, and monitoring of single-molecule physical, chemical, and biological systems, and deepen our understanding of their basic science in the single-molecule level.

Broadband and high-efficiency polarization conversion with a nano-kirigami based metasurface.

Nano-kirigami metasurfaces have attracted increasing attention due to their ease of three-dimension (3D) nanofabrication, versatile shape transformations, appealing manipulation capabilities and rich potential applications in nanophotonic devices. Through adding an out-of-plane degree of freedom to the double split-ring resonators (DSRR) by using nano-kirigami method, in this work we demonstrate the broadband and high-efficiency linear polarization conversion in the near-infrared wavelength band. Specifically, when the two-dimensional DSRR precursors are transformed into 3D counterparts, a polarization conversion ratio (PCR) of more than 90% is realized in wide spectral range from 1160 to 2030 nm. Furthermore, we demonstrate that the high-performance and broadband PCR can be readily tailored by deliberately deforming the vertical displacement or adjusting the structural parameters. Finally, as a proof-of-concept demonstration, the proposal is successfully verified by adopting the nano-kirigami fabrication method. The studied nano-kirigami based polymorphic DSRR mimic a sequence of discrete bulk optical components with multifunction, thereby eliminating the need for their mutual alignment and opening new possibilities.

Atomistic-Continuum Study of an Ultrafast Melting Process Controlled by a Femtosecond Laser-Pulse Train.

In femtosecond laser fabrication, the laser-pulse train shows great promise in improving processing efficiency, quality, and precision. This research investigates the influence of pulse number, pulse interval, and pulse energy ratio on the lateral and longitudinal ultrafast melting process using an experiment and the molecular dynamics coupling two-temperature model (MD-TTM model), which incorporates temperature-dependent thermophysical parameters. The comparison of experimental and simulation results under single and double pulses proves the reliability of the MD-TTM model and indicates that as the pulse number increases, the melting threshold at the edge region of the laser spot decreases, resulting in a larger diameter of the melting region in the 2D lateral melting results. Using the same model, the lateral melting results of five pulses are simulated. Moreover, the longitudinal melting results are also predicted, and an increasing pulse number leads to a greater early-stage melting depth in the melting process. In the case of double femtosecond laser pulses, the pulse interval and pulse energy ratio also affect the early-stage melting depth, with the best enhancement observed with a 2 ps interval and a 3:7 energy ratio. However, pulse number, pulse energy ratio, and pulse interval do not affect the final melting depth with the same total energies. The findings mean that the phenomena of melting region can be flexibly manipulated through the laser-pulse train, which is expected to be applied to improve the structural precision and boundary quality.

Rechargeable Metasurfaces for Dynamic Color Display Based on a Compositional and Mechanical Dual-Altered Mechanism.

Dynamic color display can be realized by tunable optical metasurfaces based on the compositional or structural control. However, it is still a challenge to realize the efficient modulation by a single-field method. Here, we report a novel compositional and mechanical dual-altered rechargeable metasurface for reversible and broadband optical reconfiguration in both visible and near-infrared wavelength regions. By employing a simple fabrication and integration strategy, the continuous optical reconfiguration is manipulated through an electro-chemo-mechanical coupled process in a lithium ion battery, where lithiation and delithiation processes occur dynamically under a low electric voltage (≤1.5 V). By controlling the phase transformation from Si to Li xSi, both structural morphology and optical scattering could be rapidly and dramatically tailored within 30 s, exhibiting high-contrast colorization and decolorization in a large-area nanofilm and showing long cyclic stability. Significant wide-angle reconfiguration of high-resolution structural colors in bowtie metasurfaces is demonstrated from anomalous reflection. The results provide a multifield mechanism for reconfigurable photonic devices, and the new platform can be introduced to the multidimensional information encryption and storage.

Plasmonic Nanosensors with Extraordinary Sensitivity to Molecularly Enantioselective Recognition at Nanoscale Interfaces.

Molecular chirality recognition plays a pivotal role in chiral generation and transfer in living systems and makes important contribution to the development of diverse applications spanning from chiral separation to soft nanorobots. To detect chirality recognition, most of the molecular sensors described to date are based on the design and preparation of the host-guest complexation with chromophore or fluorophore at the reporter unit. Nevertheless, the involved tedious procedures and complicated chemical syntheses hamper their practical applications. Here, we report the plasmonically chiroptical detection of molecular chirality recognition without the need for a chromophore or fluorophore unit. This facile methodology is based on plasmonic nanotransducers that can convert molecular chirality recognitions occurring at nanoscale interfaces into asymmetrically amplified plasmonic circular dichroism readouts, enabling enantiospecific recognition and quantitative determination of the enantiomeric excess of small amino acids. Importantly, such a plasmon-based chirality sensing shows 102-103 amplification in the plasmonic circular dichroism signals from the detections of racemate and near-racemate of molecular analysts, demonstrating an extraordinary sensitivity to the host-guest enantioselective interactions. Furthermore, with advantages of easy-processing, cost-effective, and specific to interfacial molecular chirality, our chiroptical sensing scheme could hold considerable promise toward applications of enantioselective high-throughput screening in biology, stereochemistry, and pharmaceutics.

Ultra-sensitive amplitude engineering and sign reversal of circular dichroism in quasi-3D chiral nanostructures.

Circular dichroism (CD), as one of the most representative chiroptical effects, provides a simple strategy for the detection and characterization of the molecular chirality. The enhancement and sign reversal of CD are of great importance for its practical applications in chiral bio-sensing, chirality switching and optical filtering, etc. Here, we realize considerable adjustments and the sign reversal of CD in quasi-three-dimensional (quasi-3D) combined Archimedean spiral nanostructures. With special local and lattice configurations, the nanostructures have both right-handed and left-handed geometric chirality, which are designed based on the proximity effect of stencil lithography. We find that the CD response of the nanostructures becomes obvious once its height exceeds 200 nm and can be adjusted by the further increase of the height or the change of the blade spacing of the nanostructures. The CD reversal is achieved by utilizing the competition of two chiral centers when the height or blade spacing exceeds a critical value. Further analysis of the scattering power of multipole moments reveals that the CD modulation is determined by both magnetic dipole moment and electric quadrupole moment. Benefiting from the highly sensitive CD response to the height, the extreme sign reversal of CD is achieved when a sub-10-nm ultrathin medium layer is anchored on the surface of the nanostructures, which provides a promising strategy for ultra-sensitive chiral bio-sensing.

Reprogrammable optical metasurfaces by electromechanical reconfiguration.

Metasurfaces, with artificially designed ultrathin and compact optical elements, enable versatile manipulation of the amplitude, phase, and polarization of light waves. While most of the metasurfaces are static and passive, here we propose a reprogrammable metasurface based on the state-of-art electromechanical nano-kirigami, which allows for independent manipulation of pixels at visible wavelengths through mechanical deformation of the nanostructures. By incorporating electrostatic forces between the top suspended gold nano-architectures and bottom silicon substrate, out-of-plane deformation of each pixel and the associated phase retardation are independently controlled by applying single voltage to variable pixels or exerting programmable voltage distribution on identical pixels. As a proof-of-concept demonstration, the metasurfaces are digitally controlled and a series of tunable metasurface holograms such as 3D dynamic display and ultrathin planar lenses are achieved at visible wavelengths. The proposed electromechanical metasurface provides a new methodology to explore versatile reconfigurable and programmable functionalities that may lead to advances in a variety of applications such as hologram, 3D displays, data storage, spatial light modulations, and information processing.

Adaptable Invisibility Management Using Kirigami-Inspired Transformable Metamaterials.

Many real-world applications, including adaptive radar scanning and smart stealth, require reconfigurable multifunctional devices to simultaneously manipulate multiple degrees of freedom of electromagnetic (EM) waves in an on-demand manner. Recently, kirigami technique, affording versatile and unconventional structural transformation, has been introduced to endow metamaterials with the capability of controlling EM waves in a reconfigurable manner. Here, we report for a kirigami-inspired sparse meta-architecture, with structural density of 1.5% in terms of the occupation space, for adaptive invisibility based on independent operations of frequency, bandwidth, and amplitude. Based on the general principle of dipolar management via structural reconstruction of kirigami-inspired meta-architectures, we demonstrate reconfigurable invisibility management with abundant EM functions and a wide tuning range using three enantiomers (A, B, and C) of different geometries characterized by the folding angle ß. Our strategy circumvents issues of limited abilities, narrow tuning range, extreme condition, and high cost raised by available reconfigurable metamaterials, providing a new avenue toward multifunctional smart devices.

Artificial Propeller Chirality and Counterintuitive Reversal of Circular Dichroism in Twisted Meta-molecules.

Here we demonstrate an optical propeller chirality in artificially twisted meta-molecules, which is remarkably different from conventional optical helical chirality. Giant circular dichroism (CD) is realized in a single layer of meta-molecule array by utilizing the surface lattice resonances that are formed by the coupling of chiral electric quadrupole modes to the diffractive lattice mode. Due to the special twist of the propeller blades, the periodic meta-molecule array is hybridized by unit cells with two different chiral centers. As a result, the CD response is readily reversed by tailoring the interference phase through engineering the structural blades without inverting the geometric chirality. Importantly, the enhanced CD and its sign reversal are demonstrated in experiments by using a nano-kirigami fabrication technique.

Effects of music stimulus on behavior response, cortisol level, and horizontal immunity of growing pigs.

An enriched environment is widely used to improve domestic animals' welfare and promote their natural behaviors. Music can reduce abnormal behavior in humans, nonhuman primates, and rodents. However, little is known about the effects of music on pigs. This study aims to explore the effects of repeated music stimulation on the behavior, physiology, and immunity of growing pigs. A total of 72 hybrid piglets (Large White × Duroc × Minpig) were randomly divided into three groups, including music (Mozart K.448, 60 to 70 dB), noise (recorded mechanical noise, 80 to 85 dB), and control (natural background sound, <40 dB), and 6 h sound stimulation was given per day (1000 to 1600 hours) from 40 to 100 d of age. The behavioral activities of the pigs were observed during the music stimulation, and their serum cortisol, salivary cortisol, and serum immune indices were also measured. Compared with the control group, the music group and noise group increased activity but decreased lying of pigs (P < 0.05). A significant increase in tail-wagging, playing, and exploring behaviors of pigs was found in the music group (P < 0.05), and the noise significantly increased the aggressive behavior of the pigs (P < 0.05). Tail-wagging, playing, exploring, manipulating, and aggressive behaviors decreased over time. Short-term (8 d) music stimulus had a lower cortisol level than that of the noise and control groups (P < 0.05), whereas long-term (60 d) music stimulus increased immunoglobulin G (IgG), interleukin-2 (IL-2), and interferon-gamma (IFN-γ) levels (P < 0.05) and decreased interleukin-4 (IL-4) level (P < 0.05). Long-term noise stimulus significantly reduced the level of IgG (P < 0.05) but did not affect the level of IL-2, IL-4, and IFN-γ levels (P > 0.05). In conclusion, short-term music stimulus (8 d) reduced the stress response, whereas long-term music stimulus (60 d) enhanced the immune responses. In addition, the noise increased the aggressive behavior, and long-term noise reduced the immunity of the growing pigs.

Electromechanically reconfigurable optical nano-kirigami.

Kirigami, with facile and automated fashion of three-dimensional (3D) transformations, offers an unconventional approach for realizing cutting-edge optical nano-electromechanical systems. Here, we demonstrate an on-chip and electromechanically reconfigurable nano-kirigami with optical functionalities. The nano-electromechanical system is built on an Au/SiO2/Si substrate and operated via attractive electrostatic forces between the top gold nanostructure and bottom silicon substrate. Large-range nano-kirigami like 3D deformations are clearly observed and reversibly engineered, with scalable pitch size down to 0.975 µm. Broadband nonresonant and narrowband resonant optical reconfigurations are achieved at visible and near-infrared wavelengths, respectively, with a high modulation contrast up to 494%. On-chip modulation of optical helicity is further demonstrated in submicron nano-kirigami at near-infrared wavelengths. Such small-size and high-contrast reconfigurable optical nano-kirigami provides advanced methodologies and platforms for versatile on-chip manipulation of light at nanoscale.