Evaluating the Impact of Uncertainty Visualization on Model Reliance.

Machine learning models have gained traction as decision support tools for tasks that require processing copious amounts of data. However, to achieve the primary benefits of automating this part of decision-making, people must be able to trust the machine learning model's outputs. In order to enhance people's trust and promote appropriate reliance on the model, visualization techniques such as interactive model steering, performance analysis, model comparison, and uncertainty visualization have been proposed. In this study, we tested the effects of two uncertainty visualization techniques in a college admissions forecasting task, under two task difficulty levels, using Amazon's Mechanical Turk platform. Results show that (1) people's reliance on the model depends on the task difficulty and level of machine uncertainty and (2) ordinal forms of expressing model uncertainty are more likely to calibrate model usage behavior. These outcomes emphasize that reliance on decision support tools can depend on the cognitive accessibility of the visualization technique and perceptions of model performance and task difficulty.

Rexinoids Modulate Effector T Cell Expression of Mucosal Homing Markers CCR9 and α4ß7 Integrin and Direct Their Migration In Vitro.

Altering T cell trafficking to mucosal regions can enhance immune responses towards pathogenic infections and cancers at these sites, leading to better outcomes. All-trans-retinoic acid (ATRA) promotes T cell migration to mucosal surfaces by inducing transcription of the mucosal-homing receptors CCR9 and α4ß7 via binding to retinoic acid receptors (RARs), which heterodimerize with retinoid X receptors (RXRs) to function. However, the unstable nature and toxicity of ATRA limit its use as a widespread treatment modality for mucosal diseases. Therefore, identifying alternatives that could reduce or eliminate the use of ATRA are needed. Rexinoids are synthetically derived compounds structurally similar to ATRA. Originally named for their ability to bind RXRs, rexinoids can enhance RAR-mediated gene transcription. Furthermore, rexinoids are more stable than ATRA and possess an improved safety profile, making them attractive candidates for use in clinical settings. Here we show that select novel rexinoids act as ATRA mimics, as they cause increased CCR9 and α4ß7 expression and enhanced migration to the CCR9 ligand, CCL25 in vitro, even in the absence of ATRA. Conversely, other rexinoids act synergistically with ATRA, as culturing cells with suboptimal doses of both compounds resulted in CCR9 expression and migration to CCL25. Overall, our findings show that rexinoids can be used independently or synergistically with ATRA to promote mucosal homing of T cells in vitro, and lends support for the prospective clinical use of these compounds in immunotherapeutic approaches for pathogenic infections or cancers at mucosal surfaces.