ABSTRACT
Experiments were performed on eight subjects affected by peripheral arterial occlusive disease (PAOD) of the lower limbs. Each patient was submitted to Ecodoppler, angiography and the "Treadmill test". Two bioptic muscle of these patients. A sample was used for the spectrophotometric and spectrophotofluorimetric determinations of: glycogen, pyruvate, lactate, citrate, alpha-ketoglutarate, malate, aspartate, glutamate, AMP, ADP, ATP and creatine phosphate (CP). The other bioptic sample was used to determine the following enzyme activities: hexokinase, phosphofructokinase, pyruvate kinase, lactate dehydrogenase, citrate synthase, succinate dehydrogenase, malate dehydrogenase, total NADH cytochrome c reductase, cytochrome oxidase, aspartate aminotransferase and alanine aminotransferase. Patients showed an increase in lactate dehydrogenase, total NADH cytochrome c reductase and succinate dehydrogenase activities, a decrease in glycogen, ATP and CP concentrations. Telethermographic data showed patient muscle thermic emission quantitatively different from control group. The telethermographic test can be used as an additional diagnostic tool to determine and monitor the efficiency of a muscle undergoing metabolic failure.
Subject(s)
Ischemia/metabolism , Leg/blood supply , Peripheral Vascular Diseases/metabolism , Adult , Aged , Body Temperature , Humans , Ischemia/diagnosis , Ischemia/physiopathology , Ischemia/surgery , Male , Middle Aged , Muscle, Skeletal/metabolism , Peripheral Vascular Diseases/diagnosis , Peripheral Vascular Diseases/physiopathology , Peripheral Vascular Diseases/surgery , ThermographyABSTRACT
A total of 60 patients with acute varicophlebitis or acute superficial thrombophlebitis of the lower limbs were recruited to this randomised double-blind comparative study, which evaluated the efficacy and tolerability of oral nimesulide (100mg twice daily) with those of diclofenac (50 mg/kg twice daily) over a period of < or = 20 days (average duration 13.6 days for nimesulide and 12.6 days for diclofenac). The analgesic effect of both drugs was rapid. Spontaneous pain disappeared within 3 to 5 days of commencing therapy, and pain on palpation within 7 days. Reduced inflammation was observed after approximately 15 days, and total resolution of redness and swelling was observed by day 20. Telethermographic assessment showed a reduction in local temperature, either in absolute terms or in the extent of inflammation. Indeed, 93% of patients showed complete recovery while 7% of patients showed a partial reduction in hyperthermia. For these latter patients, medical treatment was extended, although the subjective symptoms of the disease were no longer present. The comparison between nimesulide and the reference drug, diclofenac sodium, showed no significant difference for any of the considered parameters. Both drugs were well tolerated and no patient reported an adverse event.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Diclofenac/therapeutic use , Sulfonamides/therapeutic use , Thrombophlebitis/drug therapy , Adolescent , Adult , Aged , Body Temperature/drug effects , Diclofenac/adverse effects , Double-Blind Method , Female , Humans , Male , Middle Aged , Sulfonamides/adverse effectsSubject(s)
Flurbiprofen/therapeutic use , Phenylbutazone/therapeutic use , Propionates/therapeutic use , Thrombophlebitis/drug therapy , Vascular Diseases/drug therapy , Adult , Aged , Anti-Inflammatory Agents/therapeutic use , Female , Humans , Leg/blood supply , Male , Middle Aged , Varicose Veins/drug therapySubject(s)
Arteriosclerosis Obliterans/drug therapy , Leg/blood supply , Piperazines/therapeutic use , Piribedil/therapeutic use , Adult , Aged , Arteriosclerosis Obliterans/physiopathology , Chronic Disease , Drug Evaluation , Drug Tolerance , Female , Humans , Male , Middle Aged , Piribedil/administration & dosageABSTRACT
Personal experience with human chorionic gonadotropin in the treatment of chronic obliterating peripheral atherosclerosis of the lower limbs in various stages in a series of 54 persenile and senile subjects is reported. Following protracted i.m. administration, the product normalised blood lipid values and brought about the regression of attenuation of subjective and objective symptoms that had been disclosed instrumentally in many cases. It is felt, therefore, that this drug can be used as a further weapon in the treatment of these arteriopathies.