ABSTRACT
The authors report four cases of sinonasal lymphomas with immunophenotypic (four cases) and genotypic (three cases) studies. These lymphomas are frequent in Oriental countries, but unusual in Western populations, particularly in France. Although they have been originally considered as T-cell lymphomas, their origin remains unclear, and several authors have recently suggested that they are a natural killer (NK)-cell proliferation. The tumor cells of the four cases reported here showed characteristics of NK cells. On cryostat sections, they were CD3 negative, but CD2 and CD56 positive. The cytoplasm of the tumor cells exhibited azurophilic granulations. Using polymerase chain reaction (PCR), no clonal rearrangement of the T-cell receptor gamma gene was present. Furthermore, clinically, two presented a pharyngeal involvement, and two were also characterized by hepatosplenic involvement at the time of the diagnosis. Thus, the present cases provide additional evidence toward the NK-cell origin of these rare lymphomas. Many sinonasal lymphomas, including the present cases, are positive for Epstein-Barr virus (EBV) (LMP-1 antibody and EBER-messenger RNA probes). This may suggest an important role of EBV as a local factor in their pathogenesis.
Subject(s)
Lymphoma/pathology , Nasopharyngeal Neoplasms/pathology , Adult , Aged , Cell Line , Gene Rearrangement , Herpesvirus 4, Human/genetics , Humans , Immunohistochemistry , Killer Cells, Natural/pathology , Lymphoma/metabolism , Lymphoma/virology , Male , Middle Aged , Nasopharyngeal Neoplasms/metabolism , Nasopharyngeal Neoplasms/virology , RNA, Messenger/analysis , RNA, Viral/analysis , Receptors, Antigen, T-Cell, gamma-delta/geneticsABSTRACT
Blindly executed for a long period with only X- Ray detection, renal biopsy benefits nowadays of precision and security of real-time echoguiding. The authors describe their technique without bondage between needle and transducer and comment their results about 413 examinations.
Subject(s)
Biopsy, Needle/methods , Kidney Diseases/diagnosis , Adolescent , Adult , Aged , Aged, 80 and over , Biopsy, Needle/adverse effects , Child , Child, Preschool , Female , Hematoma/etiology , Hematuria/etiology , Humans , Infant , Kidney Diseases/etiology , Male , Middle Aged , UltrasonographyABSTRACT
Blindly executed for a long period with only X-ray detection, renal biopsy benefits nowadays of precision and security of real-time echoguiding. The authors describe their technique without bondage between needle and transducer and comment their results about 413 examinations.