ABSTRACT
PURPOSE: To evaluate the impact of optimized trigger threshold on 40-keV pancreatic phase images acquired with a dual-energy CT (DECT) protocol. METHODS: A cohort of 69 consecutive participants (median age, 72 years) undergoing a pancreatic protocol DECT examination between September to December 2021 were prospectively randomized into two protocols: conventional trigger threshold of 100 HU (Group A, n = 34) and optimized trigger threshold of 30 HU (Group B, n = 35). Pancreatic phase image acquisition was performed with fixed delay of 20 s from the trigger threshold. Two radiologists assessed the 40-keV pancreatic phase images for scan timing adequacy using a binary scale (adequate or inadequate). The proportions of these classifications were compared in the two groups using the Fisher's test. RESULTS: The median times to achieve the aortic attenuation of 30 HU and 100 HU were 16.3 s and 22.3 s in Group A, respectively, and was 17.8 s for 30 HU in Group B. The median time difference from 30 HU to 100 HU was 4.5 s in Group A. The scan timing adequacies of pancreatic phase images were classified as adequate (50.0% and 74.3%) or inadequate (50.0% and 25.7%) in Group A and Group B (P = 0.049). CONCLUSION: An optimized trigger threshold of 30 HU allows consistent acquisition of adequate pancreatic phase images compared to the conventional trigger threshold of 100 HU for pancreatic protocol DECT at 40-keV which might lead to improved pancreatic lesion conspicuity.
ABSTRACT
PURPOSE: To compare the diagnostic performance of 40 keV and 70 keV virtual monoenergetic images (VMIs) generated from dual-energy CT in the detection of pancreatic cancer. METHODS: This retrospective study included patients who underwent pancreatic protocol dual-energy CT from January 2019 to August 2022. Four radiologists (1-11 years of experience), who were blinded to the final diagnosis, independently and randomly interpreted 40 keV and 70 keV VMIs and graded the presence or absence of pancreatic cancer. For each image set (40 keV and 70 keV VMIs), the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated. The diagnostic performance of each image set was compared using generalized estimating equations. RESULTS: Overall, 137 patients (median age, 71 years; interquartile range, 63-78 years; 77 men) were included. Among them, 62 patients (45%) had pathologically proven pancreatic cancer. The 40 keV VMIs had higher specificity (75% vs. 67%; P < .001), PPV (76% vs. 71%; P < .001), and accuracy (85% vs. 81%; P = .001) than the 70 keV VMIs. On the contrary, 40 keV VMIs had lower sensitivity (96% vs. 98%; P = .02) and NPV (96% vs. 98%; P = .004) than 70 keV VMIs. However, the diagnostic confidence in patients with (P < .001) and without (P = .001) pancreatic cancer was improved in 40 keV VMIs than in 70 keV VMIs. CONCLUSIONS: The 40 keV VMIs showed better diagnostic performance in diagnosing pancreatic cancer than the 70 keV VMIs, along with higher reader confidence.