MONTE-CARLO SIMULATION USING PHITS OF SECONDARY NEUTRONS PRODUCED IN-PATIENT DURING 16O ION THERAPY.

In hadrontherapy, oxygen ions 16O can be currently considered as an alternative to carbon ions 12C designed specifically for the treatment of deep and radioresistant tumors. Secondary particles, particularly neutrons constitute a serious problem of undesirable additional irradiation to surrounding healthy tissue. The objective of this study is to evaluate, by Monte-Carlo simulation [code Particle and Heavy Ion Transport code System (PHITS)], the contribution in terms of dose of secondary neutrons produced during interaction 16O ion of 300 MeV u-1 in a soft tissue phantom. The dose of 16O ion, secondary particles and neutrons is evaluated, as well as the particle fluence and energy spectra of neutrons. The contribution to the total dose of secondary neutrons in a soft tissue phantom represents 0.1%. This dose, although apparently insignificant, is essential to conduct even more in-depth studies to understand the long-term effects of these secondary neutrons on the patient's body especially in pediatric case.

Conception and realization of a parallel-plate free-air ionization chamber for the absolute dosimetry of an ultrasoft X-ray beam.

We report the design of a millimeter-sized parallel plate free-air ionization chamber (IC) aimed at determining the absolute air kerma rate of an ultra-soft X-ray beam (E = 1.5 keV). The size of the IC was determined so that the measurement volume satisfies the condition of charged-particle equilibrium. The correction factors necessary to properly measure the absolute kerma using the IC have been established. Particular attention was given to the determination of the effective mean energy for the 1.5 keV photons using the PENELOPE code. Other correction factors were determined by means of computer simulation (COMSOL™ and FLUKA). Measurements of air kerma rates under specific operating parameters of the lab-bench X-ray source have been performed at various distances from that source and compared to Monte Carlo calculations. We show that the developed ionization chamber makes it possible to determine accurate photon fluence rates in routine work and will constitute substantial time-savings for future radiobiological experiments based on the use of ultra-soft X-rays.