Subject(s)
Diabetes Mellitus/etiology , Porphyria Cutanea Tarda/complications , Female , Humans , MaleSubject(s)
Anemia, Pernicious/complications , Anemia, Pernicious/drug therapy , Deglutition Disorders/therapy , Parakeratosis/drug therapy , Vitamin B 12/therapeutic use , Deglutition Disorders/etiology , Esophagus/pathology , Female , Humans , Middle Aged , Parakeratosis/etiology , Parakeratosis/pathologyABSTRACT
BACKGROUND: The presence of active brown adipose tissue (BAT) has been associated with a reduced risk of obesity in adult humans. AIM: To examine whether the presence and activity of BAT in patients undergoing PET-CT examinations is related to the presence of fatty liver. METHOD: We retrospectively analysed 3666 consecutive PET-CT whole-body scans performed on a total of 1832 patients who were referred for suspected malignancies. BAT-positive subjects (BAT+) were defined as subjects who showed substantial amounts of brown adipose tissue on PET-CT scans. In areas where uptake of [(18)F]FDG was identified by CT for BAT, the maximal standardised uptake values (SUVmax), defined as the maximum activity per millilitre within the region of interest divided by the injected dose in megabecquerels per gram of body weight, were determined. A ratio of mean liver attenuation to spleen attenuation <0.8 on CT scans was considered to indicate NAFLD. RESULTS: Thirty patients of the 1832 screened individuals (2%) demonstrated brown fat uptake (BAT+ subjects). Ninety matched individuals without evidence of BAT on PET scans (BAT- subjects) were enrolled for comparison purposes. After adjustment for potential confounders, the odds ratio for having NAFLD was significantly higher for BAT- subjects (3.12, 95% confidence interval = 1.03-9.88, P < 0.05). The SUVmax for brown fat tissue was significantly correlated with the ratio of mean liver attenuation to spleen attenuation (P < 0.05). CONCLUSION: The presence of brown adipose tissue in adulthood is independently associated with a lower likelihood of NAFLD diagnosed by CT findings.
Subject(s)
Adipose Tissue, Brown/metabolism , Fatty Liver/metabolism , Adult , Blood Glucose/metabolism , Body Mass Index , Fatty Liver/diagnostic imaging , Fluorodeoxyglucose F18 , Humans , Liver/diagnostic imaging , Middle Aged , Multimodal Imaging/methods , Non-alcoholic Fatty Liver Disease , Odds Ratio , Positron-Emission Tomography , Retrospective Studies , Risk Factors , Tomography, X-Ray ComputedSubject(s)
Hepatitis, Autoimmune , Liver Cirrhosis, Biliary , Lupus Erythematosus, Systemic , Comorbidity , Hepatitis, Autoimmune/epidemiology , Hepatitis, Autoimmune/immunology , Hepatitis, Autoimmune/pathology , Humans , Liver/enzymology , Liver/pathology , Liver Cirrhosis, Biliary/epidemiology , Liver Cirrhosis, Biliary/immunology , Liver Cirrhosis, Biliary/pathology , Lupus Erythematosus, Systemic/epidemiology , Lupus Erythematosus, Systemic/immunology , Lupus Erythematosus, Systemic/pathologySubject(s)
Gastrointestinal Hemorrhage/drug therapy , Phytotherapy , Plant Extracts/therapeutic use , Proctitis/drug therapy , Radiation Injuries/drug therapy , Aged , Endoscopy, Gastrointestinal , Female , Gastrointestinal Hemorrhage/etiology , Humans , Laser Coagulation , Lasers, Gas/therapeutic use , Male , Middle Aged , Plant Extracts/administration & dosage , Proctitis/complications , Proctitis/etiology , Radiation Injuries/complications , Rectal Diseases/drug therapy , Rectum/radiation effects , Recurrence , Treatment Failure , Ulcer/drug therapySubject(s)
Blood Donors , Hepatitis B, Chronic/diagnosis , Hepatitis B/diagnosis , Transfusion Reaction , Viremia/diagnosis , Acute Disease , Adult , Crohn Disease/complications , Crohn Disease/drug therapy , DNA, Viral/blood , Diagnosis, Differential , False Negative Reactions , Hepatitis B/transmission , Hepatitis B Antibodies/blood , Hepatitis B Core Antigens/immunology , Hepatitis B Surface Antigens/blood , Hepatitis B virus/physiology , Humans , Immunocompromised Host , Immunosuppressive Agents/pharmacology , Immunosuppressive Agents/therapeutic use , Male , Virus ActivationABSTRACT
We present here the case of a 31-year-old man that developed facial petechiae after unsedated upper gastrointestinal endoscopy. The lesions disappeared completely after 5 days. In English literature, only one patient similar to ours has been reported. The most likely explanation of this condition is a Valsalva maneuver that raised the intrathoracic or abdominal pressure and resulted in a rupture of capillaries in the skin. Endoscopists should therefore be aware of this rare and reversible complication.