Reaching for the stars: Iranian nurses' perceptions of career success.

AIM: The aim was to explore nurses' perceptions of career success. INTRODUCTION: Career success is a concept which leads to improving professional behaviours. Research that focused on conceptualizing career success found it to be a complex, value-driven construct likely to be perceived differently across work and cultural contexts. It is not yet clear what constitutes career success, and how it is perceived by nurses in Iran. More comprehensive exploration of this concept in nursing is needed, so research and policymaking can advance in informed, data-driven manner. METHOD: This is a qualitative descriptive study. The setting was teaching hospitals of Iran. Twenty-seven nurses participated in face-to-face interviews, and six field notes were collected. Data were analysed using conventional content analysis. FINDINGS: Analyses identified five themes of career success: providing high-quality care, being exemplary employee, embarking on career growth, having positive personal attributes and being internally satisfied. CONCLUSION: Findings confirmed that career success in Iranian nurses was a multidimensional concept that represented five internally and externally driven dimensions set within its cultural and religious context. Policymakers and clinical educators can now plan interventions aimed at fostering career success in nursing staff. IMPLICATIONS FOR EDUCATION, NURSING AND HEALTH POLICIES: Future nurses could use these finding to reflect on their developed attributes throughout their studies and clinical placements and adjust their career preparation and learning to bridge any identified gaps. Organizational values and intervention for nursing staff could also be redesigned to align with the aspects of career success.

The effect of Riluzole on functional recovery of locomotion in the rat sciatic nerve crush model.

PURPOSE: Peripheral nerve injury (PNI) is common disorder that represents more than 3 % of all traumatic injury cases. One type of PNI, sciatic nerve injury, leads to considerable motoneuron dysfunction. Because Riluzole is clinically approved for the treatment of motoneuron disease, we evaluated whether Riluzole treatment could enhance the nerve regeneration process and improve functional outcome after sciatic nerve crush in rats. METHODS: In acute treatment groups, a single dose of Riluzole (6 and 8 mg/kg) was administered intra-peritoneally 15 min after the crush nerve injury. In the chronic treatment groups, animals were treated with Riluzole (4 and 6 mg/kg/d) for 8 days. Sciatic functional index (SFI) was evaluated for 9 weeks after injury. Furthermore, electrophysiological and morphometric evaluations were performed at the 9th week following injury. RESULTS: Acute and chronic administrations of Riluzole immediately after sciatic nerve crush result in significantly delayed regeneration and reduced motor function outcome. CONCLUSIONS: These findings suggest that early administration of even a single dose of Riluzole after sciatic nerve crush injury can delay motor function recovery. This effect may not depend on its anti-nociceptive activity.

The Effect of Spiritual Care on Mental Health in Mothers of Children With Cancer.

This study measured the effect of spiritual care on mental health in mothers of children with cancer. The present quasi-experimental study was with one group pretest posttest design. The findings show that implementation of spiritual care in mothers of children with cancer can improve their mental health.

Brain ventricle development in H. huso (Beluga sturgeon) larvae.

The development of ventricles in the brain of H. huso (Beluga sturgeon) from 1 to 54 days old is presented in this study. The components observed in the 1-day-old ventricular system were the telencephalic, tectal, and cerebellar ventricles. These ventricles were not observed to have any recess or sulcus. They were surrounded by copious ependymal and embryonic cells. Two different parts were detected in the 6-day-old telencephalic ventricle: the olfactory and lateral ventricle. The olfactory ventricle was observed as a cranial extension of the telencephalic ventricle from 6 days old, as was the inner cell layer of the olfactory bulb (ic) adjacent to this extension. In the preoptic region, the lateral ventricle was connected to the preoptic recess from 15 days old, and this recess was connected by the interventricular foramen to the third ventricle in the diencephalon. At 6 days old, the third ventricle in the diencephalon was visible at the caudal part of the lateral ventricle, and the third ventricle had a recess near to the inferior lobe of the hypothalamus. At 6 days old, the tectal ventricle was observed to have bilateral extensions which proceeded to grow with age. The cerebellar ventricle, situated between the two lobes of the cerebellum, was observed from 1 day old. The cerebellar ventricle grew with age, extending laterally from 6 days old. The connection of the cerebellar ventricle to the fourth ventricle in the medulla oblongata was visible from 6 days old. Upon dividing the ventricular system into three regions (forebrain, midbrain, and hindbrain), stereological studies performed utiizing Cavalieri's principle indicated that the forebrain ventricular region had the smallest volume while the hindbrain ventricular region had the largest.

Iranian nurses' perspectives on factors influencing medication errors.

BACKGROUND: Medical errors are one of the major threats for patient safety in all countries. Medication errors are common medical mistakes that can lead to serious consequences and even death of patients. AIM: The aim of this study was to explore nurses' perspectives of factors influencing medication errors. METHODS: This qualitative study based on content analysis included 20 nurses (n = 20) with at least 2 years of clinical experience working in a large teaching hospital. The nurses were selected using purposeful sampling. The data were collected using semi-structured interviews and analysed using deductive content analysis approach based on Reason's human error model. Rigor of the data was confirmed by external and member check. RESULTS: Two themes were identified by the participants: (1) the individual approach including personal and psychological characteristics of nurses, patient medical history and physicians' orders errors; and (2) the cultural and organizational approach including workplace conditions, learning process, risk management strategies, nurses' pharmacological knowledge, inevitable nursing errors and medication error complications. LIMITATIONS: Concern about the potential consequences related to reporting of the medication errors was the major limitation of this study. Participants' concerns were handled by keeping their identity confidential and anonymous. CONCLUSION: Results show the importance of planning comprehensive educational programmes and providing constructive feedback in a favourable learning climate. IMPLICATIONS FOR NURSING AND HEALTH POLICY: Findings of this study can be beneficial to managers for nurturing a transparent organizational culture, whereby staff members freely discuss their errors in patient care and seek advice for problem solving.

A comparative study on the effects of type I and type II diabetes on learning and memory deficit and hippocampal neuronal loss in rat.

AIM: In addition to learning and memory impairments, diabetes may also brings about neuronal loss in different regions of the brain specially hippocampus. In this line, the present study was conducted to investigate the effects of type I (T1D) and type II (T2D) diabetes on cognitive function and hippocampal neuronal density in rat. METHODS: Three groups of male Wistar rats (N.=6) were regarded as control, T1D and T2D. T1D was induced by 60 mg/kg body weight of STZ injection and T2D by 10% fructose treatment through drinking water. Two months after the induction of both types of diabetes, learning abilities and memory retention of animals were measured using Morris Water Maze and shuttle box. All animals were perfused afterwards and their brains processed for stereological examination of hippocampal neuronal density. RESULTS: In parallel to significant decrease in learning and memory scores, T1D showed a meaningful reduction in hippocampal neuronal density, when compared to control group. In T2D, the reductions of cognitive scores as well as hippocampal neuronal density were not significant, when compared to control and T1D. CONCLUSION: Although both types of diabetes led to neuronal loss and spatial learning and memory dysfunction, these abnormalities were more obvious in T1D, while they are probably age-related and duration-dependent in T2D.

Study on ovine abortion associated with Toxoplasma gondii in affected herds of Khorasan Razavi Province, Iran based on PCR detection of fetal brains and maternal serology.

Toxoplasma gondii, an obligatory intracellular protozoan parasite, is one of the causative agents of ovine abortion, as reported in many countries. Different techniques are being used to detect this pathogen in infected ovine fetuses. One of the most sensitive and specific diagnostic techniques is Nested-PCR amplification of the B1 target gene of the organism. In total, 200 brain samples of aborted ovine fetuses and maternal sera submitted from different parts of Khorasan Razavi province, Iran were investigated to track the role of Toxoplasma gondii in ovine abortion by a slightly modified Nested-PCR and IFAT assays, respectively. Among all samples, 27 (13·5%) were PCR-positive and 31 (15·5%) were IFAT-positive and the Toxoplasma-induced abortion prevalence calculated was 8·8% to 18·2% with 95% confidence interval. Results show that high levels of congenital transmission may occur in 27/31(87%) of pregnancies with an excellent logical agreement (ĸ=0·9) between 2 different tests. According to the results of this study, the Nested-PCR employed in this investigation could be recommended as an applied routine test for the routine examination and confirmation of Toxoplasma gondii-induced ovine abortion.

Studies on the carbohydrate moiety and on the biosynthesis of rat C-reactive protein.

Rat C-reactive protein (CRP) is a pentameric glycoprotein composed of five apparently identical monomers, two of which form a disulfide-linked dimer (Rasosouli, M., Sambasivam, H., Azadi, P., Dell, A., Morris, H. R., Nagpurkar, A., Mookerjea, S., and Murray, R. K. (1992) J. Biol. Chem. 267, 2947-2954). In this study, the nature of the oligosaccharide chain of rat CRP was investigated by fast atom bombardment-mass spectrometry (FAB-MS), and general features of its biosynthetic pathway were also analyzed. FAB-MS, electrospray-mass spectrometry, and linkage analysis demonstrated that each monomer of rat CRP contained one oligosaccharide chain, predominantly a disialylated biantennary structure, attached to Asn-128. The biosynthesis of rat CRP was studied by immunoprecipitation of CRP synthesized in vitro and by cultured hepatocytes. The results revealed that each monomer of rat CRP was synthesized individually as a single-chain precursor with a cleavable signal sequence. The translocated species was sensitive to digestion by endoglycosidase H (endo H), indicating that it possessed a high mannose oligosaccharide. Rat CRP acquired the ability to bind to phosphorylcholine-Sepharose and to form the dimeric and oligomeric species prior to acquiring resistance to endo H. Studies using tunicamycin revealed that the N-linked oligosaccharide present in rat CRP was not required for formation of its dimeric component, oligomerization, ability to bind to phosphorylcholine, or secretion. The non-glycosylated rat CRP, however, was still able to bind to phosphorylcholine-Sepharose and to be secreted by hepatocytes.

Derivation of the amino acid sequence of rat C-reactive protein from cDNA cloning with additional studies on the nature of its dimeric component.

Rat C-reactive protein (CRP) is unique among mammalian CRPs in being a glycoprotein and in containing a covalently linked dimer in its pentameric structure. To investigate these features, cDNA clones encoding rat CRP were isolated from an expression library, and the primary structure of the protein was derived. Taken along with the results of Northern blotting, we conclude that a single mRNA of approximately 2,500 nucleotides codes for a precursor of rat CRP with a signal sequence of 19 amino acids and a polypeptide of 211 amino acids, the latter sharing extensive homology with human, rabbit, and mouse CRPs. The deduced sequence agreed with results obtained from partial microsequencing and mapping by fast atom bombardment-mass spectrometry. Two potential sites for N-glycosylation (Asn-128 and Asn-147) and a C-terminal heptapeptide (Leu-205 to Ser-211, containing two cysteines at positions 208 and 209) were unique to rat CRP. The protein was also shown to be composed of five apparently identical monomers, two of which form a dimer linked by two interchain disulfide bonds involving Cys-208 and Cys-209. These same cysteines form an intrachain disulfide bond in the other three monomers. The primary structure of rat CRP and the basis of dimer formation have, therefore, been elucidated.

Hypokalemic myopathy due to chronic alcoholism.

A patient with hypokalemic myopathy occurring in the context of chronic alcoholism was reported. A 56-year-old male patient, heavy drinker for 20 years, complained of marked weakness and acutely developing pains in his limbs. The principal clinical findings were weakness and tenderness of the proximal limbs and girdle muscle. He was unable to lift his head or any extremities from the bed. Deep tendon reflexes were diminished, but not absent. There was no sensory disturbance except for muscle tenderness. These clinical manifestations disappeared gradually by abstinence from drinking, and potassium administration therapy, and the patient recovered completely on the 26th day after onset. On the day after admission (8th day), serum potassium value was 2.2 mEq/L, and serum CPK activity was 4270 IU. The ECG pattern was consistent with a diagnosis of low potassium content in serum, and the EMG pattern was consistent with a diagnosis of myopathy. These electrophysiological findings had a tendency to recover from this pattern to normal range correspondingly with clinical improvement. The repeated muscle biopsies showed that vacuolation, hyaline degeneration and significant phagocyte infiltration were observed in the muscle on the 9th day after the onset of muscle weakness, and that these pathological findings disappeared almost completely three weeks later. The frequently repeated examinations of potassium content and CPK activity in sera showed that there was a close correlation between these biochemical abnormalities and clinical improvement. The pathogenesis of alcoholic myopathy and significance of CPK abnormality in chronic alcoholism were discussed.