Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 65
Filter
1.
Appl Radiat Isot ; 194: 110675, 2023 Apr.
Article in English | MEDLINE | ID: mdl-36706517

ABSTRACT

The results of a European intercomparison on 222Rn in water were analyzed to evaluate the performances of standard and non-standard methods. Then, results obtained with a specific LSC method (ISO 13164-4) based on two-phase liquid scintillation counting which has been employed by a considerable number of participants were examined in detail. This ISO LSC method was proved to be accurate, reliable and its reproducibility has been also sufficient. The intercomparison could be used as a collaborative study and the analysis of its results allowed to estimate the method reproducibility.

2.
Proc Natl Acad Sci U S A ; 116(34): 16750-16759, 2019 08 20.
Article in English | MEDLINE | ID: mdl-31350352

ABSTRACT

In October 2017, most European countries reported unique atmospheric detections of aerosol-bound radioruthenium (106Ru). The range of concentrations varied from some tenths of µBq·m-3 to more than 150 mBq·m-3 The widespread detection at such considerable (yet innocuous) levels suggested a considerable release. To compare activity reports of airborne 106Ru with different sampling periods, concentrations were reconstructed based on the most probable plume presence duration at each location. Based on airborne concentration spreading and chemical considerations, it is possible to assume that the release occurred in the Southern Urals region (Russian Federation). The 106Ru age was estimated to be about 2 years. It exhibited highly soluble and less soluble fractions in aqueous media, high radiopurity (lack of concomitant radionuclides), and volatility between 700 and 1,000 °C, thus suggesting a release at an advanced stage in the reprocessing of nuclear fuel. The amount and isotopic characteristics of the radioruthenium release may indicate a context with the production of a large 144Ce source for a neutrino experiment.

3.
Environ Sci Technol ; 52(15): 8488-8500, 2018 08 07.
Article in English | MEDLINE | ID: mdl-29979581

ABSTRACT

Traces of particulate radioactive iodine (131I) were detected in the European atmosphere in January/February 2017. Concentrations of this nuclear fission product were very low, ranging 0.1 to 10 µBq m-3 except at one location in western Russia where they reached up to several mBq m-3. Detections have been reported continuously over an 8-week period by about 30 monitoring stations. We examine possible emission source apportionments and rank them considering their expected contribution in terms of orders of magnitude from typical routine releases: radiopharmaceutical production units > sewage sludge incinerators > nuclear power plants > spontaneous fission of uranium in soil. Inverse modeling simulations indicate that the widespread detections of 131I resulted from the combination of multiple source releases. Among them, those from radiopharmaceutical production units remain the most likely. One of them is located in Western Russia and its estimated source term complies with authorized limits. Other existing sources related to 131I use (medical purposes or sewage sludge incineration) can explain detections on a rather local scale. As an enhancing factor, the prevailing wintertime meteorological situations marked by strong temperature inversions led to poor dispersion conditions that resulted in higher concentrations exceeding usual detection limits in use within the informal Ring of Five (Ro5) monitoring network.


Subject(s)
Air Pollutants, Radioactive , Thyroid Neoplasms , Europe , Humans , Iodine Radioisotopes , Russia
4.
Brain Res ; 1677: 26-32, 2017 Dec 15.
Article in English | MEDLINE | ID: mdl-28951233

ABSTRACT

Mutations in the SCN1A gene causing either loss or gain of function have been frequently found in patients affected by genetic epilepsy with febrile seizures plus (GEFS+) or Dravet syndrome (also named severe myoclonic epilepsy in infancy SMEI). By mutation screening of the SCN1A gene, we identified for the first time a case of two missense mutations in cis (p.[Arg1525Gln;Thr297Ile]) in all affected individuals of an Italian family showing GEFS+ and idiopathic generalized epilepsy (IGE). The p.Arg1525Gln mutation was not previously reported yet and was predicted to be pathological by prediction tools, whereas the p.Thr297Ile was already identified in patients showing SMEI. Functional studies revealed that the Nav1.1 channels harboring both mutations were characterized by a significant shift in the activation curve towards more positive potentials. Our data demonstrate that the p.Arg1525Gln represents a novel mutation in the SCN1A gene altering the channel properties in the co-presence of the p.Thr297Ile.


Subject(s)
Epilepsy, Generalized/genetics , Mutation, Missense , NAV1.1 Voltage-Gated Sodium Channel/genetics , NAV1.1 Voltage-Gated Sodium Channel/metabolism , Seizures, Febrile/genetics , Epilepsy, Generalized/physiopathology , Family , Female , HEK293 Cells , Humans , Male , Membrane Potentials/physiology , Patch-Clamp Techniques , Seizures, Febrile/physiopathology
5.
Appl Radiat Isot ; 103: 143-50, 2015 Sep.
Article in English | MEDLINE | ID: mdl-26093366

ABSTRACT

A simple method for measuring (226)Ra in drinking waters has been validated and validation parameters are provided. It is based on the measurement by LSC of (222)Rn, at equilibrium with (226)Ra, which is absorbed into a water immiscible scintillation cocktail (Ultima Gold F) inside the counting vial. The validated application field ranges between the detection limit (2·10(-3) Bq/kg) to 150 Bq/kg. The method has proven to be reliable, effective and suitable for wide-range measuring campaigns. A summary of results obtained in recent years is also given.

6.
J Radiol Prot ; 33(4): 809-22, 2013 Dec.
Article in English | MEDLINE | ID: mdl-24047590

ABSTRACT

Considerable levels of radium were detected in a certain fraction of the Estonian drinking water supply network. Some of these waterworks have treatment systems for the removal of (mainly) iron and manganese from drinking water. Three of these waterworks and another one equipped with a radium removal pilot plant were examined, and a specific study was conducted in order to assess the environmental compatibility of effluents and residues produced in the plants. (226)Ra and (228)Ra activity concentrations were analysed in both liquid (backwash water) and solid (sand filter and sediment) materials to evaluate their compliance, from the radiological point of view, with current Estonian legislation and international technical documents that propose reference levels for radium in effluents and residues. Also with regard to water treatment by-products, a preliminary analysis was done of possible consequences of the transposition of the European Basic Safety Standards Draft into Estonian law. Radium removal efficiency was also tested in the same plants. Iron and manganese treatment plants turned out to be scarcely effective, whilst the radium mitigation pilot plant showed a promising performance.


Subject(s)
Radium/isolation & purification , Wastewater/analysis , Wastewater/chemistry , Water Pollutants, Chemical/isolation & purification , Water Pollutants, Radioactive/isolation & purification , Water Purification/methods , Water Supply/analysis , Estonia , Radium/chemistry , Water Pollutants, Chemical/chemistry , Water Pollutants, Radioactive/chemistry
7.
J Radiol Prot ; 30(4): 761-80, 2010 Dec.
Article in English | MEDLINE | ID: mdl-21149943

ABSTRACT

In some areas of Estonia, groundwater contains a significant number of natural radionuclides, especially radium isotopes, which may cause radiation protection concern depending on the geological structure of the aquifer. Indeed, the parametric value of 0.1 mSv y⁻¹ for the total indicative dose established by European Directive 98/83/EC, adopted as a limit value in Estonian national legislation, is often exceeded. A Twinning Project between Estonia and Italy was carried out within the framework of the Estonian Transition Facility Programme, sponsored by the European Union. Its aims were to assess the radiological situation of Estonian groundwater and related health consequences. The first step was a study of Estonian aqueducts and the population served by them, and a thorough analysis of the radiological database for drinking water, from which the relevant effective doses for the population were obtained. Particular attention was devoted to doses to children and infants. Correlations between the chemical parameters were investigated, in order to suggest the best possible analytical approach. Lastly, a monitoring strategy, i.e. sampling points and sampling frequencies, was proposed.


Subject(s)
Radiation Monitoring/methods , Radium/analysis , Water Pollutants, Radioactive/analysis , Water Supply/analysis , Adolescent , Adult , Aged , Child , Child, Preschool , Estonia , Humans , Infant , Middle Aged , Radiation Dosage
8.
Horm Res Paediatr ; 73(1): 74-9, 2010.
Article in English | MEDLINE | ID: mdl-20190543

ABSTRACT

A 3.4-year-old girl was admitted to the Pediatric Department because of tall stature (116.0 cm, +5.1 SDS) and increased height velocity (16.3 cm/year, +6.1 SDS). Basal hormonal evaluation revealed elevated insulin-like growth factor I (IGF-I) levels (938 ng/ml, nv 40-190), prolactin (PRL) (98.0 ng/ml, nv 1.7-24.0) and mean growth hormone (GH) nocturnal concentration (147 ng/ml). Basal adrenal, gonadal and thyroid functions were normal. Hand-wrist bone age was 3.6 years. Magnetic resonance imaging revealed a macroadenoma with moderate suprasellar invasion. The adenoma was surgically removed and histological characterization confirmed the diagnosis of GH/PRL-secreting adenoma. The patient was admitted to our Endocrine Unit when 7.9 years old, because of the persistence of elevated GH, IGF-I and PRL levels, although there was a slight height velocity reduction and absence of tumor recurrence. Treatment with cabergoline was initiated, but only PRL levels normalized. Afterwards, octreotide long-acting release (LAR) was added without reaching the normalization of GH and IGF-I levels. Thus, treatment with octreotide LAR was discontinued and pegvisomant was added to cabergoline, leading to the normalization of IGF-I levels and height velocity without side effects. Other anterior pituitary functions were always normal. To conclude, treatment of pituitary gigantism with pegvisomant was effective and well tolerated in a young giant unresponsive to combined cabergoline and octreotide treatment.


Subject(s)
Adenoma/drug therapy , Growth Hormone-Secreting Pituitary Adenoma/drug therapy , Human Growth Hormone/analogs & derivatives , Pituitary Neoplasms/drug therapy , Prolactinoma/drug therapy , Adenoma/complications , Child, Preschool , Female , Follow-Up Studies , Gigantism/drug therapy , Gigantism/etiology , Growth Hormone-Secreting Pituitary Adenoma/complications , Hormone Antagonists/therapeutic use , Human Growth Hormone/therapeutic use , Humans , Pituitary Neoplasms/complications , Prolactinoma/complications , Treatment Outcome
9.
Neurol Sci ; 27(5): 364-8, 2006 Nov.
Article in English | MEDLINE | ID: mdl-17122949

ABSTRACT

Though a rare cause of stroke in the general population, in almost one quarter of young patients affected by stroke cervical artery dissection (CAD) is the underlying cause. Among these cases "spontaneous" dissections, intended as non-traumatic, represent about 34% of posterior circulation arterial dissection in patients aged less than 18 years. We here describe the case of a seven-year-old boy who developed a spontaneous vertebral artery dissection (VAD) leading to occipito-mesial, thalamo-capsular and cerebellar infarction. Once a traumatic origin was excluded, clinical history and laboratory findings were further analysed: fever associated with tonsillitis during the previous week, raised inflammatory indices, a throat culture positive for beta haemolysing Streptococcus group A and high titres of streptococcal antibodies were found. This case suggests that patients with CAD referred as spontaneous deserve extensive analysis. Subjects presenting with a dissection and an underlying infection are likely to have a hyperinflammatory response (although further experience is needed). In these patients immediate start of antibiotic therapy, treatment with anti-inflammatory drugs and further a lifelong prophylaxis with antibiotics before any invasive procedure are strongly recommended.


Subject(s)
Vertebral Artery Dissection/complications , Brain Infarction/etiology , Brain Infarction/pathology , Child , Humans , Magnetic Resonance Imaging , Male , Stroke/etiology , Ultrasonography, Doppler , Vertebral Artery Dissection/etiology , Vertebral Artery Dissection/pathology
10.
J Endocrinol Invest ; 29(5): 399-404, 2006 May.
Article in English | MEDLINE | ID: mdl-16794362

ABSTRACT

Several lines of evidence have suggested a role of the GH/IGF-I axis in the regulation of hemochrome. Many studies have been carried out in GH deficient children and adults about this topic, reporting predominantly a positive effect of recombinant human GH (rhGH) on red series, with no action on serum leucocytes and platelets counts. The aim of this study was to assess the impact of GH deficiency (GHD) and of rhGH replacement on blood cells count in 17 pre-pubertal children with idiopathic isolated GHD (11 males and 6 females, aged 9.1+/-0.8 yr) and in 18 patients with adult-onset GHD (12 males and 6 females, aged 47.9+/-3.0 yr). Evaluation of absolute and SD score (SDS) values of red blood cells, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, platelets and white blood cells was performed at baseline and after 12 months of rhGH treatment (0.045+/-0.001 mg/kg bw/day and 4.2+/-0.5 microg/kg bw/day for children and adults, respectively). At baseline, all patients showed low IGF-I levels. Effectiveness of rhGH therapy was documented by significant increase in height SDS, height velocity and serum IGF-I levels in children. In adults, adequacy of rhGH was demonstrated by significant increase in serum IGF-I and significant decrease in body fat. At baseline, about 25% of patients (4 of 17 children and 4 of 18 adults) showed normochromic normocytic anemia, while the other indices were normal. In 7 of the 8 anemic patients, normal levels of hemoglobin were restored on rhGH, while no change in all the other indices was observed. In conclusion, rhGH therapy at physiological doses has no effect on erythropoiesis in GHD children and adults with normal blood cells count, while in patients with normochromic normocytic anemia rhGH is able to restore normal hemoglobin levels.


Subject(s)
Erythrocyte Indices/drug effects , Human Growth Hormone/deficiency , Human Growth Hormone/therapeutic use , Adolescent , Adult , Aged , Child , Child, Preschool , Combined Modality Therapy , Female , Humans , Male , Middle Aged , Recombinant Proteins/therapeutic use
11.
Appl Radiat Isot ; 64(10-11): 1124-9, 2006.
Article in English | MEDLINE | ID: mdl-16554172

ABSTRACT

The uncertainty in measurements of gross alpha and beta activities in water samples by liquid scintillation counting with alpha/beta discrimination has been evaluated considering the problems typical of low-level measurements of environmental samples. The use of a pulse shape analysis device to discriminate alpha and beta events introduces a correlation between some of the input quantities, and it has to be considered. Main contributors to total uncertainty have been assessed by specifically designed experimental tests. Results have been fully examined and discussed.


Subject(s)
Microchemistry/methods , Radioisotopes/analysis , Scintillation Counting/methods , Water Pollutants, Radioactive/analysis , Alpha Particles , Beta Particles , Radiation Dosage , Reproducibility of Results , Scintillation Counting/instrumentation , Sensitivity and Specificity
12.
Eur Phys J E Soft Matter ; 19(1): 59-67, 2006 Jan.
Article in English | MEDLINE | ID: mdl-16446985

ABSTRACT

By performing measurements on a large class of macromolecular and colloidal systems, we show that thermophoresis (particle drift induced by thermal gradients) in aqueous solvents displays a distinctive universal dependence on temperature. For systems of particles interacting via temperature-independent forces, this behavior is strictly related to the solvent thermal expansivity, while an additional, T-independent term is needed to account for the behavior of "thermophilic" (migrating to the warmth) particles. The former relation between thermophoresis and thermal expansion may be exploited to envisage other fruitful studies of colloidal diffusion in inhomogeneous fluids.


Subject(s)
Colloids/chemistry , Macromolecular Substances/chemistry , Models, Chemical , Models, Molecular , Solvents/chemistry , Water/chemistry , Computer Simulation , Diffusion , Temperature
13.
Int J Pediatr Otorhinolaryngol ; 69(9): 1265-8, 2005 Sep.
Article in English | MEDLINE | ID: mdl-15894386

ABSTRACT

A 6-year-old girl was diagnosed to suffer from clivus osteomyelitis secondary to Enterococcus faecium infection. On the basis of the magnetic resonance image, the abscess was drained via the posterior wall of the pharyngeal tract immediately. Subsequent antibiotic therapy allowed rapid improvement and long-term healing of the osteomyelitic process without any side effect. Osteomyelitis or abscess of the clivus is very rare in adult patients and extremely rare in children. Some etiopathogenetic hypotheses are discussed in this case.


Subject(s)
Enterococcus faecium/isolation & purification , Gram-Positive Bacterial Infections/microbiology , Osteomyelitis/microbiology , Retropharyngeal Abscess/microbiology , Child , Cranial Fossa, Posterior , Drainage/methods , Female , Gram-Positive Bacterial Infections/drug therapy , Gram-Positive Bacterial Infections/surgery , Humans , Magnetic Resonance Imaging , Osteomyelitis/etiology , Osteomyelitis/surgery , Retropharyngeal Abscess/complications , Retropharyngeal Abscess/surgery , Treatment Outcome
14.
Radiat Prot Dosimetry ; 111(4): 373-6, 2004.
Article in English | MEDLINE | ID: mdl-15550705

ABSTRACT

The radiometric monitoring of tap waters has been carried out, in Northern Italy, since late the 1980s as part of the activities headed by the National Surveillance Network on environmental radioactivity. Measurements were accomplished by gamma spectrometry over large samples of water that were drained in a single place and concentrated by ion exchange resin treatment. More recently a regular, periodical monitoring was started using liquid scintillation measurements. In this manner, gross alpha and beta activities, uranium, (226)Ra and (222)Rn concentrations are determined at present. Nevertheless, a single-point sampling may be not fully representative of the whole Milano aqueduct, significantly extended and fed by a number of wells. As a control, an extended monitoring of the aqueduct was planned and variations of water radioactivity in different Milano areas have been assessed.


Subject(s)
Chromatography, Ion Exchange/methods , Radiation Monitoring/methods , Radiometry/methods , Risk Assessment/methods , Risk Assessment/organization & administration , Water Pollutants, Radioactive/analysis , Water Supply/analysis , Italy , Planning Techniques , Radiation Dosage , Risk Factors , Sample Size , Water Supply/statistics & numerical data
15.
Radiat Prot Dosimetry ; 111(1): 59-64, 2004.
Article in English | MEDLINE | ID: mdl-15367770

ABSTRACT

To evaluate the uncertainties for nuclear track detectors used in radon measurements, a full understanding is required of the physical phenomena involved and the behaviour of the instruments utilised in the measuring process. As it concerns the LR115 nuclear track detector, an overall evaluation of uncertainty was given. It was assessed taking into account different contributions and determining their relative weights. Since such detectors are often read by a spark counter device, a model to describe its behaviour was developed and a saturation factor was estimated. Its expression and its associated uncertainty are given. Hence, it has been possible to draw a calibration curve, in which all the uncertainty sources have been considered.


Subject(s)
Air Pollutants, Radioactive/analysis , Radiometry/instrumentation , Radon/analysis , Calibration , Radiometry/methods , Reproducibility of Results
16.
Anal Bioanal Chem ; 379(2): 247-53, 2004 May.
Article in English | MEDLINE | ID: mdl-15042271

ABSTRACT

In our institute, different procedures have been developed to measure the radioactivity content of drinking water both in normal and in emergency situations, such as those arising from accidental and terrorist events. A single radiometric technique, namely low level liquid scintillation counting (LSC), has been used. In emergency situations a gross activity screening is carried out without any sample treatment by a single and quick liquid scintillation counting. Alpha and beta activities can be measured in more than one hundred samples per day with sensitivities of a few Bq/L. Higher sensitivity gross alpha and beta, uranium and radium measurements can be performed on water samples after specific sample treatments. The sequential method proposed is designed in such a way that the same water sample can be used in all the stages, with slight modifications. This sequential procedure was applied in a survey of the Lombardia district. At first tap waters of the 13 largest towns were examined, then a more detailed monitoring was carried out in the surroundings of Milano and Lodi towns. The high sensitivity method for the determination of uranium isotopes was used to check the presence of depleted uranium in Lake Garda. Reduced equipment requirements and relative readiness of radiochemical procedures make LSC an attractive technique which can also be applied by laboratories lacking specific radiochemistry facilities and experience.


Subject(s)
Scintillation Counting/methods , Water Pollutants, Radioactive/analysis , Emergencies , Environmental Monitoring , Humans , Radium/analysis , Scintillation Counting/instrumentation , Surveys and Questionnaires , Uranium/analysis , Water Supply
18.
Lancet ; 358(9277): 211-2, 2001 Jul 21.
Article in English | MEDLINE | ID: mdl-11476842

ABSTRACT

A boy aged 10 years was referred to the Paediatric Department of Milan University Hospital, Milan, Italy, with a long history of pain in the lower limbs, alleviated only by exposure to cold. His legs were swollen, with multiple cutaneous ulcers. He had severe painful crises, and was totally incapacitated. After the diagnosis of erythermalgia was made, numerous treatments were tried, but none were successful. After finding growth hormone (GH) deficiency, we started treatment with recombinant GH. He had immediate relief of pain and complete healing of ulcers. We postulate that the healing of the ulcers can be attributed to the GH-promoting effect on dermal connective tissue.


Subject(s)
Erythromelalgia/drug therapy , Growth Hormone/therapeutic use , Human Growth Hormone/deficiency , Leg Ulcer/drug therapy , Wound Healing/drug effects , Child , Erythromelalgia/etiology , Humans , Leg Ulcer/etiology , Male
19.
Radiat Prot Dosimetry ; 97(4): 325-8, 2001.
Article in English | MEDLINE | ID: mdl-11878412

ABSTRACT

The uranium concentration in 59 samples of bottled and tap water, mainly from northern Italy, was measured by different techniques. Results obtained by inductively coupled plasma mass spectrometry (ICP-MS), semiconductor alpha spectrometry and low level liquid scintillation counting with alpha/beta discrimination (LSC) have been compared. High resolution gamma spectrometry and semiconductor alpha spectrometry have been used to analyse uranium in a variety of organic and inorganic samples. Isotopic secular equilibrium in the 238U series may be lacking or hidden by auto-absorption phenomena, so caution should be used in evaluating gamma spectrometry data. Alpha spectrometry has also been used to ascertain the possible pollution from depleted uranium in the environment.


Subject(s)
Food Contamination, Radioactive/analysis , Soil Pollutants, Radioactive/analysis , Uranium/analysis , Water Supply/analysis , Humans , Isotopes/analysis , Italy , Mass Spectrometry/methods , Reproducibility of Results , Scintillation Counting , Sensitivity and Specificity
20.
Pediatr Res ; 46(2): 232-8, 1999 Aug.
Article in English | MEDLINE | ID: mdl-10447120

ABSTRACT

Gitelman disease was diagnosed in two unrelated children with hypokalemic metabolic alkalosis and growth failure (a boy and a girl aged 7 mo and 9.5 y, respectively, at clinical presentation) on the basis of mutations detected in the gene encoding the thiazide-sensitive NaCl cotransporter of the distal convoluted tubule. GH deficiency was demonstrated by specific diagnostic tests in both children. Hypertonic saline infusion tests showed a partial vasopressin deficiency in the girl and delayed secretion of this hormone in the boy. Magnetic resonance imaging revealed an empty sella in both cases. Up to now, hypomagnesemia and hypocalciuria have been considered obligatory criteria for the diagnosis of Gitelman disease; however, our two patients had hypomagnesemia and hypocalciuria in less than half the determinations. GH replacement treatment was associated with a good clinical response in both children. It appears that these cases represent a new phenotype, not previously described in Gitelman disease, and that the entity may be considered a new complex hereditary renal tubular-pituitary syndrome.


Subject(s)
Bartter Syndrome , Empty Sella Syndrome , Human Growth Hormone/deficiency , Vasopressins/metabolism , Carrier Proteins/physiology , Child , Female , Humans , Kidney Tubules/physiopathology , Male , Pituitary Gland/physiopathology , Sodium-Potassium-Chloride Symporters , Syndrome
SELECTION OF CITATIONS
SEARCH DETAIL