[Immunohistochemical study of the accumulation of antibody-forming cells in the lungs following intrapulmonary and subcutaneous administration of apneumotropic antigen]. / Immunogistokhimicheskoe izuchenie nakopleniia antiteloobrazuiushchikh kletok v legkikh pri vnutrilegochnom i podkozhnom vvedenii apnevmotropnogo antigena.

Accumulation of the antibody-synthesizing cells in the lungs of guinea pigs in intratracheal and subcutaneous immunization was studied on a model of a complete typhoid bacilli antigen by means of Coons' method. Antibody-forming cells located in the interalveolar septi and in the peribronchial and perivascular connective tissue appeared with both method of the apneumotropic antigen administration. More of these cells accumulated in intrapulmonary application of the antigen. Repeated immunization by any method also led to the increase of their amount. The problem on the role played by the lungs in the immunogenesis is discussed.

[Enzymatic activity in the lung cells to the intrapulmonary administration of antigen]. / Izuchenie aktivnosti fermentov v kletkakh legkikh pri vnutrilegochnom vvedenii antigena.

Histochemical study of the activity of the redox and hydrolytic enzymes in the immunocompetent cells of the lungs of guinea pigs following intratracheal immunization with complete typhoid antigen demonstrated that following a single immunization at the initial periods elevation of the activity of AP, LDH, NAD- and NADP-diaphorases was seen in the macrophages; later GDH, G-6-PDH and AP was activated in the plasma cells. Double immunization was followed by an earlier and more intensive increase of the enzymatic activity in the cells under study.

[Morphological changes using live vaccine from the suppressor S. typhimurium revertant in model experiments]. / Morfologicheskie ismeneniia pri ispol'zovanii zhivoi vaktsiny iz supressornogo revertanta S. typhimurium v model'nykh opytakh

The work of was aimed at the morphological study of the harmlessness and protective activity of the live salmonella vaccine prepared form the suppressor S. typhimurium revertant intended for the prophylaxis and treatment of carrier state after the sustained food poisoning. It was shown to model experiments on mice that oral immunization caused no development of pathological changes, and at the same time prevented the appearance of the disease in infection of the animals by the virulent strain--S. typhimurium No. 415 in a dose of 100 LD50. A marked immunomorphological reaction developed in the small intestine and the lymphoid organs.