ABSTRACT
Plasma antithrombin III was measured by an immunological approach (AT III:Ag) using an antiserum developed in our laboratory and by its ability to inhibit thrombin (functional assay) using a chromogenic synthetic substrate in 12 patients with myocardial infarction, 9 patients with angina pectoris and 10 healthy control subjects. In the early stage (3 to 24 hours after the onset of pain) of an acute myocardial infarction AT III:Ag (115.67% +/- 21.23) was found to be significantly (p less than 0.01) higher than functional (free) AT III (92% +/- 10.27). This difference was less obvious 10 days later (AT III:Ag 118% +/- 18.93; functional AT III 104.94 +/- 14.45). There was also no significant difference between AT III:Ag and functional AT III in patients with angina pectoris as well as in controls. Since AT III:Ag represents total plasma AT III while functional AT III represents only free AT III the difference between these two variables could provide informations about the amount of the anticoagulant forming complexes with activated clotting factors. It is therefore considered that the significant increase in the difference between AT III:Ag and functional AT III in the early stage of acute myocardial infarction is likely to suggest an intravascular activation of coagulation.
Subject(s)
Angina Pectoris/blood , Antigens/blood , Antithrombin III/analysis , Myocardial Infarction/blood , Adult , Aged , Antithrombin III/immunology , Aspartate Aminotransferases/blood , Cholesterol/blood , Cholinesterases/blood , Female , Fibrinogen/analysis , Humans , Male , Middle AgedSubject(s)
Coronary Disease/blood , Hyperlipidemias/complications , Platelet Aggregation , Acute Disease , Adult , Aged , Angina Pectoris/blood , Catecholamines/blood , Chronic Disease , Fatty Acids/blood , Female , Humans , Hyperlipidemias/blood , Male , Middle Aged , Myocardial Infarction/blood , Triglycerides/bloodABSTRACT
Based on previous observations showing that in human chronic myelocytic leukemias blood histamine is about 50-100 times the normal level, this substance was studied in the blood of cows with chronic lymphocytic leukemias. The blood histamine level was found normal, thus confirming the assumption that a very high blood histamine level is specific for chronic myelocytic leukemia, in which it is a sure diagnostic element.
Subject(s)
Cattle Diseases/blood , Histamine/blood , Leukemia, Lymphoid/veterinary , Animals , Cattle , Leukemia, Lymphoid/bloodSubject(s)
Blood Platelets , Coronary Disease/blood , Acute Disease , Adult , Cholesterol/blood , Chronic Disease , Female , Humans , Hyperlipidemias/complications , Lipoproteins/blood , Male , Middle Aged , Myocardial Infarction/blood , Platelet Aggregation , Thrombosis/etiology , Triglycerides/bloodABSTRACT
Cysteine absorption was determined in an intestinal segment "in situ" in the rat under general anaesthesia, perfusing the segment twice for 30 minutes, at one hour interval, with the same amount of cysteine dissolved in a 0.85% NaCl solution. At the second perfusion, absorption of the amino acid was about half that at the first perfusion. As the first perfusion reduces absorption even in a segment not previously perfused, and intraperitoneal injection of cysteine does not influence absorption, it is postulated that an inhibitory factor, released from the intestinal wall, intervenes by humoral route in the regulating mechanism of the absorption of amino acids.