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Bioorg Med Chem Lett
; 21(13): 4066-71, 2011 Jul 01.
Article
in English
| MEDLINE
| ID: mdl-21641211
ABSTRACT
The synthesis and SAR studies of a novel N-aryl pyridinone class of p38 kinase inhibitors are described. Systematic structural modifications to the HTS lead, 5, led to the identification of (-)-4a as a clinical candidate for the treatment of inflammatory diseases. Additionally, the chiral synthesis and properties of (-)-4a are described.