ABSTRACT
Noninvasive imaging plays a pivotal role in assessing the brain structural and functional changes in presurgical mesial temporal lobe epilepsy (MTLE) patients. Our goal was to study the relationship between the changes of cerebral white matter (WM) and cognitive functions in MTLE patients.Voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) MRI were performed on 24 right-handed MTLE patients (12 with left MTLE and 12 with right MTLE) and 12 matching healthy controls. Gray matter (GM), WM, and whole brain (WB) volumes were measured with VBM while fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were measured with TBSS. All patients and controls also underwent Montreal Cognitive Assessment (MoCA) before MRI.WM volume and the ratio of WM volume versus WB volume were significantly lower in MTLE patients compared with controls. WM volume in MTLE patients had a positive correlation with MoCA score (râ=â0.71, Pâ<â.001) and a negative correlation with the duration of epilepsy (râ=â-0.693, Pâ<â.001). Volumetric differences were mainly located in the corpus callosum, uncinate fasciculus, inferior longitudinal fasciculus, and superior longitudinal fasciculus. FA of both left MTLE and right MTLE groups was significantly decreased, while MD, AD, and RD were significantly increased. Most left MTLE patients showed bilateral WM fiber tract changes versus ipsilateral changes for right MTLE patients.Changes in DTI parameters and WM volume were found in MTLE patients and more ipsilateral changes were seen with right-sided MTLE. Cognitive changes of MTLE patients were found to be correlated with the changes in WM structure. These findings not only provide useful information for lateralization of the seizure focus but can also be used to explain functional connectivity disorders which may be an important physiological basis for cognitive changes in patients with MTLE.
Subject(s)
Brain/pathology , Cognitive Dysfunction/pathology , Epilepsy, Temporal Lobe/diagnostic imaging , Gray Matter/pathology , Magnetic Resonance Imaging/methods , White Matter/pathology , Adult , Anisotropy , Brain/anatomy & histology , Brain/diagnostic imaging , Cerebrospinal Fluid/diagnostic imaging , Cognitive Dysfunction/diagnosis , Cognitive Dysfunction/etiology , Corpus Callosum/anatomy & histology , Corpus Callosum/diagnostic imaging , Corpus Callosum/pathology , Diffusion Tensor Imaging/methods , Epilepsy, Temporal Lobe/pathology , Female , Gray Matter/anatomy & histology , Gray Matter/diagnostic imaging , Humans , Magnetic Resonance Imaging/trends , Male , Nerve Net/diagnostic imaging , Nerve Net/physiopathology , Seizures/physiopathology , White Matter/anatomy & histology , White Matter/diagnostic imagingABSTRACT
Traumatic brain injury survivors often experience cognitive deficits and neuropsychiatric symptoms. However, the neurobiological mechanisms underlying specific impairments are not fully understood. Advances in neuroimaging techniques (such as diffusion tensor imaging and functional MRI) have given us new insights on structural and functional connectivity patterns of the human brain in both health and disease. The connectome derived from connectivity maps reflects the entire constellation of distributed brain networks. Using these powerful neuroimaging approaches, changes at the microstructural level can be detected through regional and global properties of neuronal networks. Here we will review recent developments in the study of brain network abnormalities in traumatic brain injury, mainly focusing on structural and functional connectivity. Some connectomic studies have provided interesting insights into the neurological dysfunction that occurs following traumatic brain injury. These techniques could eventually be helpful in developing imaging biomarkers of cognitive and neurobehavioral sequelae, as well as predicting outcome and prognosis.