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In this case series, we report a 32-year-old male patient with myocardial infarction and 45-year-old female with portal vein thrombosis with splenic infarcts, which were the initial manifestations of polycythaemia vera. The awareness of myeloproliferative disorders as a possible underlying disease-especially in young patients presenting with myocardial infarction and portal venous thrombosis-is crucial for clinical management, as a missed diagnosis can worsen the patients' further prognosis.
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Owing to their attractive energy density of about 8.1 kW h kg-1 and specific capacity of about 2.9 A h g-1, aluminum-air (Al-air) batteries have become the focus of research. Al-air batteries offer significant advantages in terms of high energy and power density, which can be applied in electric vehicles; however, there are limitations in their design and aluminum corrosion is a main bottleneck. Herein, we aim to provide a detailed overview of Al-air batteries and their reaction mechanism and electrochemical characteristics. This review emphasizes each component/sub-component including the anode, electrolyte, and air cathode together with strategies to modify the electrolyte, air-cathode, and even anode for enhanced performance. The latest advancements focusing on the specific design of Al-air batteries and their rechargeability characteristics are discussed. Finally, the constraints and prospects of their use in mobility applications are also covered in depth. Thus, the present review may pave the way for researchers and developers working in energy storage solutions to look beyond lithium/sodium ion-based storage solutions.
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This review provides a comprehensive and accessible literature review on the integration of nanoparticles into biolubricants to enhance wear and friction regulation, thus improving the overall lubricated system performance. Nanotechnology has significantly impacted various industries, particularly in lubrication. Nanobiolubricants offer promising avenues for enhancing tribological properties. This review focuses on oxide nanoparticles, such as zinc oxide (ZnO), aluminum oxide (Al2O3), copper oxide (CuO), titanium dioxide (TiO2), zirconium dioxide (ZrO2), and graphene oxide (GO) nanoparticles, for their ability to enhance lubricant performance. The impact of nanoparticle concentration on biolubricant properties, including viscosity, viscosity index, flash point temperature, and pour point temperature, is analyzed. The review also addresses potential obstacles and limitations in nanoparticle incorporation, aiming to propose effective strategies for maximizing their benefits. The findings underscore the potential of nanobiolubricants to improve operational efficiency and component lifespan. This review aims to provide valuable insights for researchers, engineers, and professionals in exploring and leveraging nanotechnology's potential in the lubrication industry. This review paper explores the basics of tribology along with its significance, green principles, mechanisms, and energy savings because of friction, wear, and lubrication. Condition monitoring techniques are also explored to achieve brief knowledge about maintaining reliability and safety of the industrial components. Recent advances in tribology including superconductivity, biotribology, high-temperature tribology, tribological simulation, hybrid polymer composite's tribology, and cryogenic tribology are investigated, which gives a thorough idea about the subject.
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To compare and evaluation of surgical operability with and without induction chemotherapy in locally advanced head and neck squamous cell carcinoma. Head and neck malignancy grossly refers to squamous cell carcinomas of head and neck (HNSCC) have multiple treatment modalities and strategies, when opted in an appropriate manner renders tumours curable. The aim of this study is to compare and evaluation of surgical operability with and without induction chemotherapy in locally advanced head and neck squamous cell carcinoma. A prospective observational study involving 50 patients of histologically proven squamous cell carcinoma of head and neck region. Patients were categorized into two major groups, group-1 patients included resectable tumour stage and group-2 included unresectable tumour stage. Both groups were compared after appropriate chemotherapy and surgical intervention. There were a total of 78% males and 22% females with majority of patients in age group of 41-60 years. 54% patients had ulcerative type of growth pattern and most patients had primary site of lesion in oral cavity. 50% patients had moderately differentiated squamous cell carcinoma. Induction chemotherapy was considered in 70% of patients, while majority of patients were belonging to T4N2M0 stage. In this study, we recommend that the borderline category of patients who are initially in an unresectable tumour stage can undergo induction chemotherapy to downstage and shrink the tumour to a resectable stage following which the appropriate surgical intervention should be done with a close monitoring and sustained follow up to prevent recurrence.
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Telematics technology and its implementation in auto insurance have received great interest due to their potential to transform the insurance sector and promote safer driving practices. By implementing telematics technology, insurers may tailor insurance premiums to individual drivers, taking into account their real driving habits and performance, ultimately leading to improved road safety, cost savings, and an empowered driving community. The current study, through bibliometric analysis, carefully identifies and evaluates the existing body of scholarly literature on this subject for the last 21 years, including journal articles, conference papers, and related publications. The analysis uncovers key research studies, influential authors, top publication outlets, top countries with collaborations, and prolific research fields, providing useful insights into the evolution and growth of telematics-based insurance research. Furthermore, thematic mapping, cluster analysis, and critical analysis of top recent studies aided in identifying key research clusters and themes, as well as potential gaps and areas for further exploration, guiding future researchers and policymakers in advancing this transformative technology.
Subject(s)
Automobile Driving , Insurance , Humans , Accidents, Traffic , Automobiles , BibliometricsABSTRACT
Cavernous hemangioma of orbit is a benign, noninfiltrative, slowly progressive vascular neoplasm. It is usually asymptomatic but patients may present with proptosis and diminished vision due to compression of second cranial nerve, optic nerve. This can be usually diagnosed with the help of clinical examination and computed tomography (CT) or magnetic resonance imaging (MRI). Small sized tumours are worth wait and watch while large ones need surgical excision. In our case report, A 65-year-old male patient presented to the head and neck surgery with proptosis of left eye since 5 years along with decreased vision since 4 years. MDCT scan (orbits plain) suggestive of large solid retroocular, intraconal mass in left orbit leading to proptosis of left eyeball. The patient underwent excision of tumour through a transnasal endoscopic approach. Histopathological examination of the tumour identified as cavernous hemangioma. It is safe and effective way to access and excise the orbital tumours through the transnasal endoscopic approach. It is essential to have experienced surgeon in endoscopic procedures. The patient had satisfactory results at three months follow up and showed no symptoms or relapse on CT scans of orbital region. Supplementary Information: The online version contains supplementary material available at 10.1007/s12070-023-03984-y.
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Two new discrete cobaloxime based complexes with the general formula [ClCo(dioxime)2L] (1 and 2), L1 = N-(4-pyridylmethyl)-1,8-naphthalamide, L2 = 4-bromo-N-(4-pyridylmethyl)-1,8-naphthalamide have been synthesized and characterized by various spectroscopic techniques such as FT-IR, 1H, 13C{1H} NMR and PXRD. The molecular structures of both complexes have also been determined using single crystal X-ray crystallography. The solid state molecular structures revealed distorted octahedral geometry around the Co(III) central metal ion with two dioximes in the equatorial plane and axial positions are occupied by chloro and pyridine nitrogen of N-(4-pyridylmethyl)-1,8-naphthalamide ligands. Both complexes exhibit weaker non-covalent interactions (C-Hâ¯O, C-Hâ¯Cl and C-Hâ¯π(Centroid) in complex 1 whereas C-Hâ¯O and C-Hâ¯Br in complex 2) resulting in the formation of dimeric and 1D supramolecular structures. Furthermore, these complexes are immobilized onto the surface of activated carbon cloth (CC) and their electrocatalytic performance for the hydrogen evolution reaction (HER) has been investigated in alkaline and acidic media as well as buffer solution. In alkaline medium, we found that complex 2 exhibited impressive electrocatalytic HER activity and produced a current density of -10 mA cm-2 at an overpotential of 260 mV, whereas complex 1 produced the same current density at an overpotential of 334 mV. An electrochemical impedance spectroscopy (EIS) spectral study revealed the faster charge transfer kinetics of complex 2 than that of complex 1. Similarly, the low Tafel slope (100 mV dec-1) for the HER with complex 2 indicates faster HER kinetics compared to complex 1. The chronoamperometric study showed that complex 2 is stable under electrocatalytic HER conditions for 5 h without losing the initial current density and it has also been established that the complex structure is retained after electrocatalysis.
Subject(s)
Pyridines , Spectroscopy, Fourier Transform Infrared , Molecular Structure , Pyridines/chemistry , Crystallography, X-RayABSTRACT
Four new functionalized Ni(II) dithiocarbamate complexes of the formula [Ni(Lx)2] (1-4) (L1 = N-methylthiophene-N-3-pyridylmethyl dithiocarbamate, L2 = N-methylthiophene-N-4-pyridylmethyl dithiocarbamate, L3 = N-benzyl-N-3-pyridylmethyl dithiocarbamate, and L4 = N-benzyl-N-4-pyridylmethyl dithiocarbamate) have been synthesized and characterized by IR, UV-vis, and 1H and 13C{1H} NMR spectroscopic techniques. The solid-state structure of complex 1 has also been determined by single crystal X-ray crystallography. Single crystal X-ray analysis revealed a monomeric centrosymmetric structure for complex 1 in which two dithiocarbamate ligands are bonded to the Ni(II) metal ion in a S^S chelating mode resulting in a square planar geometry around the nickel center. These complexes are immobilized on activated carbon cloth (CC) and their electrocatalytic performances for the oxygen evolution reaction (OER) have been investigated in aqueous alkaline solution. All the complexes act as pre-catalysts for the OER and undergo electrochemical anodic activation to form Ni(O)OH active catalysts. Spectroscopic and electrochemical characterization revealed the existence of the interface of molecular complex/Ni(O)OH, which acts as the real catalyst for the OER. The active catalyst obtained from complex 2 showed the best OER activity achieving 10 mA cm-2 current density at an overpotential of 330 mV in 1.0 M aqueous KOH solution.
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Solid lipid nanoparticles (SLNs) are one of the developed technologies for addressing the bioavailability and targeting issues of drug delivery. In this review article, we attempted to incorporate all the essential details of SLNs like various methods of preparation, different models of SLNs, updated characterization methods, in vivo behavior (uptake), their applications, route of administration as well as advancements taken place in the field of delivery of biological drugs like gene vector, new adjuvant for vaccines, protein, and peptide with SLNs. Surface modified SLNs hold excellent potential for targeted and controlled drug delivery which is discussed and summarized. Based on the available data, the future success of SLNs is widened because they could be easily fabricated with various functionalities which would display enormous potential for targeting and diagnosing various diseases. This review would help the budding researchers to find out the unexplored areas of SLNs with the present discussion that reframes the potential of SLNs by gathering the various research findings of SLNs in tabular form along with the approved patent technologies of SLNs.
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Medulloblastoma is a common term used for the juvenile malignant brain tumor, and its treatment is exciting due to different genetic origins, improper transportation of drug across the blood-brain barrier, and chemo-resistance with various side effects. Currently, medulloblastoma divided into four significant subsections (Wnt, Shh, Group 3, and Group 4) is based on their hereditary modulation and histopathological advancement. In this chapter, we tried to combine several novel chemical therapeutic agents active toward medulloblastoma therapy. All these compounds have potent activity to inhibit the medulloblastoma.
Subject(s)
Cerebellar Neoplasms , Medulloblastoma , Cerebellar Neoplasms/drug therapy , Cerebellar Neoplasms/genetics , Hedgehog Proteins/genetics , Humans , Medulloblastoma/drug therapy , Medulloblastoma/pathologyABSTRACT
Novel materials with low density are being synthesized with great interest owing to their effectiveness in water purification systems. Materials of micro/nano-scale provide outstanding results in miniature point-of-use devices because of their high surface-to-volume ratio. In this study, we report the successful synthesis of hollow polymethyl methacrylate microspheres (HPM) coated with functionalized carbon nanotubes (f-CNTs) (CHPM) by employing solvent evaporation and in situ coating techniques. The surface coating of HPM with the f-CNTs was visually confirmed by the surface roughness recorded in scanning electron microscopy. Furthermore, characterization with Fourier transform infrared spectroscopy substantiated the presence of hydroxyl and carboxyl groups of f-CNTs on the CHPM. The efficiency of CHPM to remove the turbidity from surface water was evaluated. The CHPM was effective in bringing down the turbidity of the water from 500 NTU to <1 NTU (>97%) which was within the desirable limit of the Bureau of Indian Standards. The temperature and pH for maximum reduction in turbidity were optimized to 49.5 °C and 4.5, respectively. Moreover, kinetic studies of CHPM indicated that the material followed the Langmuir isotherm model with regeneration efficiency lasting more than 10 cycles. From the results, we propose a simple, facile, and cost-effective synthetic route for the synthesis of CHPM for water purification, especially for turbidity removal. The synthesized CHPM with low density and relatively large surface area offer huge potential in water treatment applications and related fields.
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Nanotubes, Carbon , Water Pollutants, Chemical , Water Purification , Adsorption , Kinetics , Microspheres , Polymethyl Methacrylate , Spectroscopy, Fourier Transform InfraredABSTRACT
Psoriasis is an autoimmune, chronic proliferative, inflammatory skin disease with high comorbidity. Psoriasis is not a curable disease; it can only be managed. Cyclosporine A (CyA) is one of the FDA-approved immunosuppressant drug used in severe Psoriasis. Till date only oral route is used for its administration. Administration of CyA by this route causes serious side effects such as hypertension and renal toxicity. Due to these side effects, a number of researches have been done and taking place in the current times for the dermal delivery of CyA for the management of psoriasis. Dermal delivery of CyA is not an easy task because of its physiochemical properties like high molecular weight, lipophilicity and resistance offered by stratum corneum (SC). Because of the above problems in the dermal delivery a number of new approaches such as nanolipid carriers, microemulsion, liposomes, niosomes etc. are explored. To those deep findings for psoriasis management with dermal delivery of CyA have not been discussed. This comprehensive review includes all the studies, advancements and their critical findings which took place in the recent times for the dermal delivery of CyA and along with the suitable modification needed for the efficient dermal delivery of CyA are also suggested.
Subject(s)
Administration, Cutaneous , Cyclosporine , Immunosuppressive Agents , Psoriasis , Administration, Oral , Cyclosporine/administration & dosage , Cyclosporine/therapeutic use , Humans , Hypertension/chemically induced , Immunosuppressive Agents/administration & dosage , Immunosuppressive Agents/therapeutic use , Psoriasis/drug therapyABSTRACT
Rare earth elements (REE) are emerging as modern high-technology-related novel micro-contaminants in freshwater aquatic systems and are therefore attracting global attention due to their potential human health risks. The Gomati River (a tributary of the Ganga River) sediments were analyzed for REE concentrations to establish REE contamination and to identify biotite mica mineral as a geoindicator. Chondrite-normalized REE pattern of the river sediments and biotite mica mineral were similar and depict a strong light REE (LREE) enrichment and relatively flatter heavy REE (HREE). The maximum total REE (∑REE) concentration increased from 323 µg/g in 2012 to 673 µg/g in 2019. In the ∑REE, LREE contribution was > 80%, because of anthropogenic inputs, mainly petroleum-cracking catalysts and other high-technology-based products. The XRD analysis and the geochemical signature of the Gomati River sediments reveal the meaningful existence of biotite mica mineral. A distinct downstream REE enrichment pattern was identified in biotite from the mica-rich bedload sediments. The scanning electron microscopy-energy dispersive X-ray (SEM-EDX) mapping images of biotite also revealed the precipitation of Lanthanum, at the weathered edges, during the early stage of mineral weathering. Biotite mica was identified as a geoindicator for the assessment of REE contamination in the Gomati River and the Hindon River Basin of the Ganga Alluvial Plain. Future research is needed for the application of biotite mica mineral as a geoindicator that can help the environmental scientists to contribute more effectively to the interdisciplinary efforts in River Science.
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Metals, Rare Earth , Water Pollutants, Chemical , Aluminum Silicates , Environmental Monitoring , Ferrous Compounds , Humans , India , Metals, Rare Earth/analysis , Rivers , Water Pollutants, Chemical/analysisABSTRACT
Tuberculosis (TB) is a contagious disease that has affected mankind. The anti-TB treatment has been used from ancient times to control symptoms of this disease but these medications produced some serious side effects. Herbal products have been successfully used for the treatment of TB. Gold is the most biocompatible metal among all available for biomedical purposes so Gold nanoparticles (GNPs) have sought attention as an attractive biosynthesized drug to be studied in recent years for bioscience research. GNPs are used as better catalysts and due to unique small size, physical resemblance to physiological molecules, biocompatibility and non-cytotoxicity extensively used for various applications including drug and gene delivery. Greenly synthesized GNPs have much more potential in different fields because phytoconstituents used in GNP synthesis itself act as reducing and capping agents and produced more stabilized GNPs. This review is devoted to a discussion on GNPs synthesis with herbs for TB. The main focus is on the role of the natural plant bio-molecules involved in the bioreduction of metal salts during the GNPs synthesis with phytoconstituents used as antitubercular agents.
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Sulfonic acid functionalized over biguanidine fabricated silica-coated heterogeneous magnetic nanoparticles (NP@SO3H) have been synthesized, well characterized and explored for the first time, as an efficient and recyclable catalyst for N-formylation of primary amines under mild reaction conditions. Exploiting the magnetic nature of Fe3O4, the prepared catalyst was readily recovered from the reaction mixture via an external magnet. The catalyst can be reused for up to six cycles without any substantial loss of catalytic activity. The cost effectiveness, simple methodology, wide substrate tolerance, excellent yield and easy work-up are the additional advantages of present catalytic system.
Subject(s)
Intestinal Fistula/complications , Intestinal Fistula/surgery , Intestinal Obstruction/etiology , Aged , Cecum/pathology , Colon, Sigmoid/pathology , Female , Humans , Ileostomy/methods , Ileum/pathology , Intestinal Obstruction/diagnostic imaging , Laparotomy/methods , Tomography, X-Ray Computed/methods , Treatment OutcomeABSTRACT
The interaction of four benzothiazole tethered triazole analogues (MS43, MS70, MS71, and MS78) with human serum albumin (HSA) was investigated using various spectroscopic techniques (ultraviolet-visible (UV-vis) light absorption, fluorescence, circular dichroism (CD), molecular docking and density functional theory (DFT) studies). Fluorescence quenching constants (~1012 ) revealed a static mode of quenching and binding constants (Kb ~104 ) indicating the strong affinity of these analogues for HSA. Further alteration in the secondary structure of HSA in the presence of these analogues was also confirmed by far UV-CD spectroscopy. The intensity loss in CD studied at 222 nm indicated an increase in random coil/ß-sheet conformations in the protein. Binding energy values (MS71 (-9.3 kcal mol-1 ), MS78 (-8.02 kcal mol-1 ), MS70 (-7.16 kcal mol-1 ) and MS43 (-6.81 kcal mol-1 )) obtained from molecular docking revealed binding of these analogues with HSA. Molecular docking and DFT studies validated the experimental results, as these four analogues bind with HSA at site II through hydrogen bonding and hydrophobic interactions.
Subject(s)
Benzothiazoles/chemistry , Molecular Docking Simulation , Serum Albumin, Human/chemistry , Triazoles/chemistry , Humans , Spectrometry, FluorescenceABSTRACT
Whole genome sequencing (WGS) of Mycobacterium tuberculosis has been constructive in understanding its evolution, genetic diversity and the mechanisms involved in drug resistance. A large number of sequencing efforts from across the globe have revealed genetic diversity among clinical isolates and the genetic determinants for their resistance to anti-tubercular drugs. Considering the high TB burden in India, the availability of WGS studies is limited. Here we present, WGS results of 200 clinical isolates of M. tuberculosis from North India which are categorized as sensitive to first-line drugs, mono-resistant, multi-drug resistant and pre-extensively drug resistant isolates. WGS revealed that 20% of the isolates were co-infected with M. tuberculosis and non-tuberculous mycobacteria species. We identified 12,802 novel genetic variations in M. tuberculosis isolates including 343 novel SNVs in 38 genes which are known to be associated with drug resistance and are not currently used in the diagnostic kits for detection of drug resistant TB. We also identified M. tuberculosis lineage 3 to be predominant in the northern region of India. Additionally, several novel SNVs, which may potentially confer drug resistance were found to be enriched in the drug resistant isolates sampled. This study highlights the significance of employing WGS in diagnosis and for monitoring further development of MDR-TB strains.