ABSTRACT
We estimated the age dynamics of aggregation properties of platelets and red blood cells in aged rats on the background of regular muscle loads. The study was performed on 26 male rats of 12 months of age, experience during the year, daily exercise. Control is represented by 91 healthy male rats: 30 individuals (12 months), 32 rats (18 months) and 29 rats (24 months). Applied biochemistry, hematology and statistical methods. The gradual increase in control observed with age, and the erythrocyte aggregation properties of platelets. In experimental animals observed retention of activity aggregation of platelets and red blood cells at a level close to the end during the whole period of regular muscle loads.
Subject(s)
Aging/physiology , Blood Platelets/physiology , Cell Aggregation/physiology , Cellular Senescence/physiology , Erythrocytes/physiology , Motor Activity/physiology , Animals , Male , Models, Animal , Physical Conditioning, Animal/physiology , RatsABSTRACT
An increase of adhesion and aggregation functions of platelets in vivo and in vitro was detected in 5-6-year-old children with scoliosis. These disorders were caused by hyperproduction of von Willebrand's factor in the vascular wall and intensification of thromboxane production in blood platelets. Activation of thromboxane formation is the main cause of platelet hyperactivity in children with scoliosis. Correction of platelet hemostasis may include pathogenetically substantiated complex of therapeutic exercises, swimming, and massage.