An adhesive, stretchable, and freeze-resistant conductive hydrogel strain sensor for handwriting recognition and depth motion monitoring.

Wearable electronics based on conductive hydrogels (CHs) offer remarkable flexibility, conductivity, and versatility. However, the flexibility, adhesiveness, and conductivity of traditional CHs deteriorate when they freeze, thereby limiting their utility in challenging environments. In this work, we introduce a PHEA-NaSS/G hydrogel that can be conveniently fabricated into a freeze-resistant conductive hydrogel by weakening the hydrogen bonds between water molecules. This is achieved through the synergistic interaction between the charged polar end group (-SO3-) and the glycerol-water binary solvent system. The conductive hydrogel is simultaneously endowed with tunable mechanical properties and conductive pathways by the modulation caused by varying material compositions. Due to the uniform interconnectivity of the network structure resulting from strong intermolecular interactions and the enhancement effect of charged polar end-groups, the resulting hydrogel exhibits 174 kPa tensile strength, 2105 % tensile strain, and excellent sensing ability (GF = 2.86, response time: 121 ms), and the sensor is well suited for repeatable and stable monitoring of human motion. Additionally, using the Full Convolutional Network (FCN) algorithm, the sensor can be used to recognize English letter handwriting with an accuracy of 96.4 %. This hydrogel strain sensor provides a simple method for creating multi-functional electronic devices, with significant potential in the fields of multifunctional electronics such as soft robotics, health monitoring, and human-computer interaction.

Surgery, chemoradiotherapy, or chemoradiation plus immunotherapy: Treatment strategies for nonmetastatic anal squamous cell carcinoma.

The current standard of care for anal squamous cell carcinoma (ASCC) is definitive concurrent chemoradiotherapy (CRT). However, about a third of patients may experience treatment failure. Recently, immunotherapy has emerged as a novel strategy for metastatic ASCC patients. We evaluated the efficacy and safety of surgery, CRT alone, and CRT with immunotherapy (CRT-I) in 100 nonmetastatic ASCC patients, treated from April 2012 through May 2023, by determining survival outcomes and acute adverse events. The median (range) follow-up was 30.7 (7.6 to 134.9) months. The study cohort 3-year overall survival (OS), progression-free survival (PFS), distant metastasis-free survival (DMFS), and locoregional recurrence-free survival (LRFS) rates were 80.7 %, 62.2 %, 71.1 %, and 67.6 %, respectively. The Surgery group had significantly lower rates than the CRT and CRT-I groups for 3-year PFS (33.1% vs. 65.2% vs. 92.9 %, P < 0.001), DMFS (46.7% vs. 74.6% vs. 92.9 %, P = 0.002) and LRFS (37.0% vs. 73.3% vs. 92.9 %, P < 0.001), respectively. All patients receiving CRT-I were alive at last follow-up. Of 100 patients, 26 (26.0 %) experienced severe (≥ grade 3) acute toxicity. Of 24 patients receiving CRT-I, 8 (33.3 %) had severe acute toxicity. Using immunohistochemistry, peritumoural stromal infiltration by CD8+ T cells was significantly higher after CRT-I compared to before CRT-I and to after CRT alone. The addition of immunotherapy to CRT may be an effective first-line treatment option with favourable survival outcomes and acceptable toxicity for patients with ASCC. A prospective, randomized trial assessing the efficacy of CRT combined with a PD-1 inhibitor in patients with locally advanced ASCC is in progress.

Myelin oligodendrocyte glycoprotein-associated transverse myelitis after SARS-CoV-2 infection: A case report.

BACKGROUND: Cases of myelin oligodendrocyte glycoprotein (MOG) antibody-related disease have a history of coronavirus disease 2019 infection or its vaccination before disease onset. Severe acute respiratory syndrome virus 2 (SARS-CoV-2) infection has been considered to be a trigger of central nervous system autoimmune diseases. CASE SUMMARY: Here we report a 20-year male with MOG-associated transverse myelitis after a SARS-CoV-2 infection. The patient received a near-complete recovery after standard immunological treatments. CONCLUSION: Attention should be paid to the evaluation of typical or atypical neurological symptoms that may be triggered by SARS-CoV-2 infection.

Feasibility and Effectiveness of Venoarterial Extracorporeal Membrane Oxygenation Plus Intra-Aortic Balloon Pump Assisted High-Risk Percutaneous Coronary Intervention in Complex Coronary Disease.

Background: Mechanical circulatory support may facilitate high-risk percutaneous coronary intervention (PCI). This study aimed to assess the feasibility, safety and effectiveness of high-risk PCI under the support of venoarterial extracorporeal membrane oxygenation (VA-ECMO) combined with intra-aortic balloon pump (IABP). Methods: We enrolled patients who received VA-ECMO plus IABP-assisted PCI procedures at our center from April 2012 to June 2018. Major adverse cardiac events (MACEs) included all-cause death, myocardial infarction, and target vessel revascularization. Results: A total of 10 patients were included, with a mean age of 71 years, EuroSCORE II of 19.9%, and SYNTAX score of 39.8. Procedural success was achieved in nine (90%) patients. The mean duration of ECMO support was 1.5 hours, and 2.6 stents were implanted per patient. Major complications included contrast-induced nephropathy needing hemodialysis in one (10%) patient, significant hemoglobin drop requiring blood transfusion in two (20%) patients, pulmonary infection in one (10%) patient, and local surgical incision infection in one (10%) patient. The accumulative mortality rates for the nine patients with procedural success were 0, 22.2%, and 44.4% at 1, 3, and 5 years follow-up, respectively. However, cardiac death occurred in only one (11.1%) patient. In addition, two patients received repeat PCI or coronary artery bypass grafting within two years following the index procedure. The overall incidence rates of MACEs were 11.1%, 44.4%, and 66.7% at 1, 3, and 5 years follow-up, respectively. Conclusions: VA-ECMO plus IABP-assisted high-risk PCI was feasible in patients with complex coronary disease, with a high procedural success rate and acceptable mid-term clinical outcomes.

Fullerene on non-iron cluster-matrix co-catalysts promotes collaborative H2 and N2 activation for ammonia synthesis.

Developing highly effective catalysts for ammonia (NH3) synthesis is a challenging task. Even the current, prevalent iron-derived catalysts used for industrial NH3 synthesis require harsh reaction conditions and involve massive energy consumption. Here we show that anchoring buckminsterfullerene (C60) onto non-iron transition metals yields cluster-matrix co-catalysts that are highly efficient for NH3 synthesis. Such co-catalysts feature separate catalytic active sites for hydrogen and nitrogen. The 'electron buffer' behaviour of C60 balances the electron density at catalytic transition metal sites and enables the synergistic activation of nitrogen on transition metals in addition to the activation and migration of hydrogen on C60 sites. As demonstrated in long-term, continuous runs, the C60-promoting transition metal co-catalysts exhibit higher NH3 synthesis rates than catalysts without C60. With the involvement of C60, the rate-determining step in the cluster-matrix co-catalysis is found to be the hydrogenation of *NH2. C60 incorporation exemplifies a practical approach for solving hydrogen poisoning on a wide variety of oxide-supported Ru catalysts.

Rational design of a DNA-launched live attenuated vaccine against human enterovirus 71.

Human Enterovirus 71 (EV71) has emerged as one of the predominant causative agents of hand, foot and mouth disease (HFMD) with global impact. Despite the inactivated vaccine being licensed, other vaccine candidates based on advanced technology platforms are under development. In this report, we rationally designed and constructed two DNA-launched live attenuated vaccine candidates (pDL-EV71) under the control of specific promoters. In vitro and in vivo transfection with pDL-EV71 driven by the CMV promoter successfully yielded fully infectious EV71. More importantly, the administration of pDL-EV71 did not cause clinical symptoms following intracranial or intramuscular inoculation in neonatal and IFNα/ßR-/- mice, demonstrating its safety profile. Moreover, a single-dose or two-dose immunization with pDL-EV71 elicited robust neutralizing antibodies against EV71 as well as an antigen-specific cellular response in mice. A single-dose immunization with 10 â€‹µg of pDL-EV71 conferred complete protection against lethal EV71 infection in neonates born to immunized maternal mice. Overall, our present results demonstrate that pDL-EV71 is a safe and effective vaccine candidate against EV71 for further development.

A system for efficient and sustainable cogeneration of water and electricity: Temperature difference induced by photothermal conversion and evaporative cooling.

Solar energy, with its sustainable properties, has garnered considerable attention for its potential to produce green electricity and clean water. This paper proposes a multistage energy transfer co-generation system (MWCNTs-covered thermoelectric module with aerogel and cooler, AC-CTEM) combining power generation and evaporative cooling. On the light-absorbing surface, the hot side of a thermoelectric module is covered with a hydrophobic coating made of PDMS and MWCNT. The cold side transfers heat to the evaporation zone using a heat sink. Aerogel evaporators are cross-linked with chitosan and polyurethane, which reduces the enthalpy of evaporation and facilitates efficient interfacial evaporation to remove heat and return it to refrigeration. Additionally, with the addition of Fresnel lenses and wind energy to the enhancement device, the system achieved an evaporation rate of 3.445 kg m-2 h-1 and an open-circuit voltage of 201.12 mV under 1 kW m-2 solar irradiation. The AC-CTEM system also demonstrated long-term stability and effectiveness in treating various types of non-potable water. Furthermore, we demonstrated the practical utility of the system by successfully cultivating grass seeds and powering electronic equipment. The AC-CTEM system exemplifies a practical energy-saving approach for the development of highly efficient co-generation systems.

Enhanced visible light responsive piezoelectric photocatalysis based on Bi2S3 coated BaTiO3 nanorods heterostructures.

Although the presence of the built-in electric field will solve the problem of carrier complexation in photocatalytic systems to some extent. However, free carriers will quickly shield the stabilized electric field and lose its effect. Therefore, how to introduce the dynamic piezoelectric field into the photocatalytic system has become an imminent problem. Herein, we developed an overcoated, visible light responsive, piezoelectric-assisted photocatalytic system by depositing Bi2S3 photocatalysts with a narrow-band system onto the surface of highly piezo-responsive BaTiO3 nanorods (BTO NRs). The heterojunction structure, bound by Bi-O chemical bonding, enhances carrier transport efficiency under the influence of the piezoelectric field. In the degradation experiments, the first-order rate constant for the degradation of chlortetracycline hydrochloride (CTC) in the BTO NRs/Bi2S3 system with the optimal complex ratio was 0.0276 min-1, which was 3.1 and 7.8 times higher than that of BTO NRs and Bi2S3, respectively. Additionally, we deduced the degradation pathways of CTC through a combination of Density functional theory (DFT) calculations and Liquid Chromatograph Mass Spectrometer (LC-MS), evaluating the toxicity of the intermediates. This complex system, featuring a highly photo-responsive semiconductor as a photo-acceptor deposited on a piezoelectric semiconductor surface providing a dynamic built-in electric field, enhances carrier separation efficiency under optimal light energy utilization conditions. These findings present novel and effective strategies for addressing two primary challenges in photocatalytic systems: low spectral utilization and significant photogenerated carrier complexation.

Targeting renal damage: The ACE2/Ang-(1-7)/mas axis in chronic kidney disease.

The renin-angiotensin system (RAS) is a crucial factor in chronic kidney disease (CKD) progression, affecting renal function and contributing significantly to renal tissue inflammation and fibrosis. Activation of the classical ACE/Ang II/AT1 axis exacerbates renal damage, while the ACE2/Ang-(1-7)/Mas axis has shown promise in reducing CKD progression in numerous animal models. Recently, the ACE2/Ang-(1-7)/Mas axis has emerged as a promising target for CKD interventions. This review provides a comprehensive review of the pivotal role of this axis in CKD pathogenesis and systematically examines various molecules and pharmaceutical agents targeting this pathway. This review aims to elucidate potential strategies for delaying or halting CKD progression, offering patients more effective treatment options.

Dual-role epitope on SARS-CoV-2 spike enhances and neutralizes viral entry across different variants.

Grasping the roles of epitopes in viral glycoproteins is essential for unraveling the structure and function of these proteins. Up to now, all identified epitopes have been found to either neutralize, have no effect on, or enhance viral entry into cells. Here, we used nanobodies (single-domain antibodies) as probes to investigate a unique epitope on the SARS-CoV-2 spike protein, located outside the protein's receptor-binding domain. Nanobody binding to this epitope enhances the cell entry of prototypic SARS-CoV-2, while neutralizing the cell entry of SARS-CoV-2 Omicron variant. Moreover, nanobody binding to this epitope promotes both receptor binding activity and post-attachment activity of prototypic spike, explaining the enhanced viral entry. The opposite occurs with Omicron spike, explaining the neutralized viral entry. This study reveals a unique epitope that can both enhance and neutralize viral entry across distinct viral variants, suggesting that epitopes may vary their roles depending on the viral context. Consequently, antibody therapies should be assessed across different viral variants to confirm their efficacy and safety.

Single-cell and spatial transcriptome analyses reveal tertiary lymphoid structures linked to tumour progression and immunotherapy response in nasopharyngeal carcinoma.

Tertiary lymphoid structures are immune cell aggregates linked with cancer outcomes, but their interactions with tumour cell aggregates are unclear. Using nasopharyngeal carcinoma as a model, here we analyse single-cell transcriptomes of 343,829 cells from 77 biopsy and blood samples and spatially-resolved transcriptomes of 31,316 spots from 15 tumours to decipher their components and interactions with tumour cell aggregates. We identify essential cell populations in tertiary lymphoid structure, including CXCL13+ cancer-associated fibroblasts, stem-like CXCL13+CD8+ T cells, and B and T follicular helper cells. Our study shows that germinal centre reaction matures plasma cells. These plasma cells intersperse with tumour cell aggregates, promoting apoptosis of EBV-related malignant cells and enhancing immunotherapy response. CXCL13+ cancer-associated fibroblasts promote B cell adhesion and antibody production, activating CXCL13+CD8+ T cells that become exhausted in tumour cell aggregates. Tertiary lymphoid structure-related cell signatures correlate with prognosis and PD-1 blockade response, offering insights for therapeutic strategies in cancers.

Topology-preserving segmentation of abdominal muscle layers from ultrasound images.

BACKGROUND: In clinical anesthesia, precise segmentation of muscle layers from abdominal ultrasound images is crucial for identifying nerve block locations accurately. Despite deep learning advancements, challenges persist in segmenting muscle layers with accurate topology due to pseudo and weak edges caused by acoustic artifacts in ultrasound imagery. PURPOSE: To assist anesthesiologists in locating nerve block areas, we have developed a novel deep learning algorithm that can accurately segment muscle layers in abdominal ultrasound images with interference. METHODS: We propose a comprehensive approach emphasizing the preservation of the segmentation's low-rank property to ensure correct topology. Our methodology integrates a Semantic Feature Extraction (SFE) module for redundant encoding, a Low-rank Reconstruction (LR) module to compress this encoding, and an Edge Reconstruction (ER) module to refine segmentation boundaries. Our evaluation involved rigorous testing on clinical datasets, comparing our algorithm against seven established deep learning-based segmentation methods using metrics such as Mean Intersection-over-Union (MIoU) and Hausdorff distance (HD). Statistical rigor was ensured through effect size quantification with Cliff's Delta, Multivariate Analysis of Variance (MANOVA) for multivariate analysis, and application of the Holm-Bonferroni method for multiple comparisons correction. RESULTS: We demonstrate that our method outperforms other industry-recognized deep learning approaches on both MIoU and HD metrics, achieving the best outcomes with 88.21%/4.98 ( p m a x = 0.1893 $p_{max}=0.1893$ ) on the standard test set and 85.48%/6.98 ( p m a x = 0.0448 $p_{max}=0.0448$ ) on the challenging test set. The best&worst results for the other models on the standard test set were (87.20%/5.72)&(83.69%/8.12), and on the challenging test set were (81.25%/10.00)&(71.74%/16.82). Ablation studies further validate the distinct contributions of the proposed modules, which synergistically achieve a balance between maintaining topological integrity and edge precision. CONCLUSIONS: Our findings validate the effective segmentation of muscle layers with accurate topology in complex ultrasound images, leveraging low-rank constraints. The proposed method not only advances the field of medical imaging segmentation but also offers practical benefits for clinical anesthesia by improving the reliability of nerve block localization.

Polyvinyl alcohol /chitosan biomimetic hydrogel enhanced by MXene for excellent electromagnetic shielding and pressure sensing.

Traditional electromagnetic shielding materials are difficult to realize practical applications due to excessive fillers, poor mechanical properties, and difficulty in preservation, etc. Hydrogel is a biomaterial with good biocompatibility and sustainability, which not only can overcome the aforementioned issues, but its biomimetic hierarchical porous structure also enables multifunctional applications. In this paper, a honeycomb-like unidirectional porous wall structured hydrogel is prepared by a simple freeze-thaw cycle and salting out method. Polyvinyl alcohol (PVA) and chitosan (CS) form a double cross-linked network (DN) enhanced by MXene, resulting in excellent mechanical and flexibility. Due to the synergistic effects of MXene, water, Fe3O4, abundant interfaces and micrometer porous wall structure, the electromagnetic shielding performance is enhanced. EMI SE increases by 30.7 dB as the MXene concentration increases from 0 to 1.5 wt%, and EMI SE increases from 7.9 to 66.7 dB as the water content increases from 0 to 76 %. Besides this, we encapsulate the hydrogel into a simple sensor, the signal response is rapid, the response /recovery time is 50/100 ms respectively, and it exhibits good sensitivity (0.0187 kPa-1). Different signals are generated based on variations in pressure, which holds significant importance for the development of wearable flexible sensors and information encoding.

Development of biomass aerogels with aligned channels: For continuous treatment of oily wastewater and solar-powered oil evaporation.

A biomass CS/CNTs@MTMS (MCCS) aerogel with both aligned channel network, superhydrophobicity, and photothermal conversion ability was prepared by a green and facile strategy of directed freeze-drying and chemical vapor deposition using chitosan (CS), carbon nanotubes (CNTs), and methyltrimethoxysilane (MTMS) as the building materials. Capacity to adsorb a large variety of oils and organic solvents, with an adsorption capacity of up to 34-83 g/g. After 10 cycles, the adsorption capacity of MCCS remained at 94 % of the initial capacity, providing excellent reusability. In addition, due to its unique network of aligned channels, the MCCS can continuously separate oil and water, making it a sustainable oil-water separator. More interestingly, the MCCS aerogel has excellent photothermal conversion capabilities, and it was utilized to evaporate oil collected during the oil-water separation process using solar energy. This work provides an opportunity to design novel self-cleaning photothermally driven oil-water separation biomass materials with superhydrophobicity-strong lipophilicity.

Design and preparation of hydrogel microspheres for spinal cord injury repair.

A severe disorder known as spinal cord damage causes both motor and sensory impairment in the limbs, significantly reducing the patients' quality of life. After a spinal cord injury, functional recovery and therapy have emerged as critical concerns. Hydrogel microspheres have garnered a lot of interest lately because of their enormous promise in the field of spinal cord injury rehabilitation. The material classification of hydrogel microspheres (natural and synthetic macromolecule polymers) and their synthesis methods are examined in this work. This work also covers the introduction of several kinds of hydrogel microspheres and their use as carriers in the realm of treating spinal cord injuries. Lastly, the study reviews the future prospects for hydrogel microspheres and highlights their limitations and problems. This paper can offer feasible ideas for researchers to advance the application of hydrogel microspheres in the field of spinal cord injury.

Dimerization activates the Inversin complex in C. elegans.

Genetic, colocalization, and biochemical studies suggest that the ankyrin repeat-containing proteins Inversin (INVS) and ANKS6 function with the NEK8 kinase to control tissue patterning and maintain organ physiology. It is unknown whether these three proteins assemble into a static "Inversin complex" or one that adopts multiple bioactive forms. Through the characterization of hyperactive alleles in C. elegans, we discovered that the Inversin complex is activated by dimerization. Genome engineering of an RFP tag onto the nematode homologues of INVS (MLT-4) and NEK8 (NEKL-2) induced a gain-of-function, cyst-like phenotype that was suppressed by monomerization of the fluorescent tag. Stimulated dimerization of MLT-4 or NEKL-2 using optogenetics was sufficient to recapitulate the phenotype of a constitutively active Inversin complex. Further, dimerization of NEKL-2 bypassed a lethal MLT-4 mutant, demonstrating that the dimeric form is required for function. We propose that dynamic switching between at least two functionally distinct states - an active dimer and an inactive monomer - gates the output of the Inversin complex.

Fukushima Daiichi Nuclear Power Plant Accident: Understanding Formation Mechanism of Radioactive Particles through Sr and Pu Quantities.

The Fukushima Daiichi Nuclear Power Plant accident released considerable radionuclides into the environment. Radioactive particles, composed mainly of SiO2, emerged as distinctive features, revealing insights into the accident's dynamics. While studies extensively focused on high-volatile radionuclides like Cs, investigations into low-volatile nuclides such as 90Sr and Pu remain limited. Understanding their abundance in radioactive particles is crucial for deciphering the accident's details, including reactor temperatures and injection processes. Here, we aimed to determine 90Sr and Pu amounts in radioactive particles and provide essential data for understanding the formation processes and conditions within the reactor during the accident. We employed radiochemical analysis on nine radioactive particles and determined the amounts of 90Sr and Pu in these particles. 90Sr and Pu quantification in radioactive particles showed that the 90Sr/137Cs radioactivity ratio (corrected to March 11, 2011) aligned with core temperature expectations. However, the 239+240Pu/137Cs activity ratio indicated nonvolatile Pu introduction, possibly through fuel fragments. Analyzing 90Sr and Pu enhances our understanding of the Fukushima Daiichi accident. Deviations in 239+240Pu/137Cs activity ratios underscore nonvolatile processes, emphasizing the accident's complexity. Future research should expand this data set for a more comprehensive understanding of the accident's nuances.

Natural herbal extract roles and mechanisms in treating cerebral ischemia: A systematic review.

Background: Stroke has been the focus of medical research due to its serious consequences and sequelae. Among the tens of millions of new stroke patients every year, cerebral ischemia patients account for the vast majority. While cerebral ischemia drug research and development is still ongoing, most drugs are terminated at preclinical stages due to their unacceptable toxic side effects. In recent years, natural herbs have received considerable attention in the pharmaceutical research and development field due to their low toxicity levels. Numerous studies have shown that natural herbs exert actions that cannot be ignored when treating cerebral ischemia. Methods: We reviewed and summarized the therapeutic effects and mechanisms of different natural herbal extracts on cerebral ischemia to promote their application in this field. We used keywords such as "natural herbal extract," "herbal medicine," "Chinese herbal medicine" and "cerebral ischemia" to comprehensively search PubMed, ScienceDirect, ScienceNet, CNKI, and Wanfang databases, after which we conducted a detailed screening and review strategy. Results: We included 120 high-quality studies up to 10 January 2024. Natural herbal extracts had significant roles in cerebral ischemia treatments via several molecular mechanisms, such as improving regional blood flow disorders, protecting the blood-brain barrier, and inhibiting neuronal apoptosis, oxidative stress and inflammatory responses. Conclusion: Natural herbal extracts are represented by low toxicity and high curative effects, and will become indispensable therapeutic options in the cerebral ischemia treatment field.

First-Principles Calculations of the Effect of γ-Alumina Surface Hydroxyl Structures on the Location and Dechlorination of a Platinum Precursor.

The interaction between Pt precursors and alumina support is an important step in synthesizing Pt/Al2O3 catalysts, while an in-depth understanding of the interaction is still lacking. Herein, density functional theory (DFT) calculations were performed to simulate the coordination of H2PtCl6 with different surface hydroxyl groups, revealing the influence of the γ-Al2O3 surface hydroxyl structure on the position of the Pt precursor and the removal of Cl ligands. After drying, the interaction mechanism between [PtCl6]2- and alumina support involves hydrogen bonds and van der Waals forces, which are the main driving forces for the structural transformation from [PtCl6]2- coordinated with the surface hydroxyl group into the PtClx(OH)y species (OH is the γ-Al2O3 surface group). HO-µ1-AlVI and H2O-µ1-AlVI on the (100) surface with electrophilicity facilitate hauling and activating the electron-rich [PtCl6]2-, but the nucleophilic (110) surface has a weaker interaction with [PtCl6]2-. Combining free energy and electronic property analysis, the stable structures on the (100) surface after drying treatment are PtCl4(OH)2 and PtCl3(OH)3, while only PtCl4(OH)2 structures can be formed on the (110) surface. This study can deepen our understanding of the interaction mechanism between Al-hydroxyl groups and Pt precursors, providing a theoretical reference for the precise placement of Pt active phases and the construction of metal-support interfaces.

Rising incidence of obesity-related cancers among younger adults in China: A population-based analysis (2007-2021).

BACKGROUND: Developing countries face an "obesity epidemic," particularly affecting children and younger adults. While obesity is a known risk factor for 12 types of cancer, primarily affecting older populations, its impact on younger generations is understudied. METHODS: This study analyzed data from a population-based cancer registry covering 14.14 million individuals in China (2007-2021). We compared the incidence of obesity- and non-obesity-related cancers and applied an age-period-cohort model to estimate their impacts. FINDINGS: Among 651,342 cancer cases, 48.47% were obesity related. The age-standardized incidence rates (ASRs) of the 12 obesity-related cancers increased annually by 3.6% (p < 0.001), while ASRs for non-obesity-related cancers remained stable. Obesity-related cancers surged among younger adults, with rates rising across successive generations. The annual percentage of change decreased with age, from 15.28% for ages 25-29 years to 1.55% for ages 60-64 years. The incidence rate ratio for obesity-related cancer was higher in younger generations compared to those born in 1962-1966. We predict that the ASR for obesity-related cancers will nearly double in the next decade. CONCLUSIONS: The rising incidence of obesity-related cancers among young adults poses a significant public health concern. The increasing cancer burden underscores the need for targeted interventions to address the obesity epidemic. FUNDING: This work was supported by the National Natural Science Foundation of China (81930019, 82341076) to J.-K.Y.