ABSTRACT
Clinical, histological and electron microscopic studies were performed on 4 rhinoscleroma patients with concomitant skin lesions in the upper lip, dorsum of the nose and nasolacrymal sac area. The skin lesions were treated locally. One of the patients was followed up to 16 years. Histologically, the skin lesions showed downward prolongation of the rete pegs. Deep in the dermis, vacuolated Mikulicz cells surrounded by lymphocytes and plasma cells were found. By electron microscopy, numerous small vacuoles containing fine granular material were seen inside Mikulicz cells. A limited number of bacilli were found inside and outside these cells. Two clinical entities of rhinoscleroma are observed in Egypt, an active granulomatous type with possible extranasal extension, and a less active intranasal type with limited mucosal lesions. The skin lesions in rhinoscleroma were found to have an unpredictable course.
Subject(s)
Rhinoscleroma/pathology , Skin/ultrastructure , Adolescent , Adult , Biopsy , Cytoplasmic Granules/ultrastructure , Humans , Male , Microscopy, Electron , Middle Aged , Vacuoles/ultrastructureABSTRACT
The increased interest in lymph and lymphatics has cast its mantle over the portal circulation. Lymphography has contributed greately to our knowledge. In the present study percutaneous transhepatic lymphography showed some of the factors sharing in the production of portal hypertension in schistosomal hepatic fibrosis, and gave a further evidence that the liver is not a source of excess lymph production in hepatic lesions associated with presinusoidal block to portal blood flow. Hepatic lymphatics were opacified in cases with mixed cirrhosis and schistosomal hepatic fibrosis as the sinusoidal pressure is elevated with subsequent cases increase in hepatic lymph production.