Transformers meets neoantigen detection: a systematic literature review.

Cancer immunology offers a new alternative to traditional cancer treatments, such as radiotherapy and chemotherapy. One notable alternative is the development of personalized vaccines based on cancer neoantigens. Moreover, Transformers are considered a revolutionary development in artificial intelligence with a significant impact on natural language processing (NLP) tasks and have been utilized in proteomics studies in recent years. In this context, we conducted a systematic literature review to investigate how Transformers are applied in each stage of the neoantigen detection process. Additionally, we mapped current pipelines and examined the results of clinical trials involving cancer vaccines.

Pedagogical sentiment analysis based on the BERT-CNN-BiGRU-attention model in the context of intercultural communication barriers.

Amid the wave of globalization, the phenomenon of cultural amalgamation has surged in frequency, bringing to the fore the heightened prominence of challenges inherent in cross-cultural communication. To address these challenges, contemporary research has shifted its focus to human-computer dialogue. Especially in the educational paradigm of human-computer dialogue, analysing emotion recognition in user dialogues is particularly important. Accurately identify and understand users' emotional tendencies and the efficiency and experience of human-computer interaction and play. This study aims to improve the capability of language emotion recognition in human-computer dialogue. It proposes a hybrid model (BCBA) based on bidirectional encoder representations from transformers (BERT), convolutional neural networks (CNN), bidirectional gated recurrent units (BiGRU), and the attention mechanism. This model leverages the BERT model to extract semantic and syntactic features from the text. Simultaneously, it integrates CNN and BiGRU networks to delve deeper into textual features, enhancing the model's proficiency in nuanced sentiment recognition. Furthermore, by introducing the attention mechanism, the model can assign different weights to words based on their emotional tendencies. This enables it to prioritize words with discernible emotional inclinations for more precise sentiment analysis. The BCBA model has achieved remarkable results in emotion recognition and classification tasks through experimental validation on two datasets. The model has significantly improved both accuracy and F1 scores, with an average accuracy of 0.84 and an average F1 score of 0.8. The confusion matrix analysis reveals a minimal classification error rate for this model. Additionally, as the number of iterations increases, the model's recall rate stabilizes at approximately 0.7. This accomplishment demonstrates the model's robust capabilities in semantic understanding and sentiment analysis and showcases its advantages in handling emotional characteristics in language expressions within a cross-cultural context. The BCBA model proposed in this study provides effective technical support for emotion recognition in human-computer dialogue, which is of great significance for building more intelligent and user-friendly human-computer interaction systems. In the future, we will continue to optimize the model's structure, improve its capability in handling complex emotions and cross-lingual emotion recognition, and explore applying the model to more practical scenarios to further promote the development and application of human-computer dialogue technology.

3MTox: A motif-level graph-based multi-view chemical language model for toxicity identification with deep interpretation.

Toxicity identification plays a key role in maintaining human health, as it can alert humans to the potential hazards caused by long-term exposure to a wide variety of chemical compounds. Experimental methods for determining toxicity are time-consuming, and costly, while computational methods offer an alternative for the early identification of toxicity. For example, some classical ML and DL methods, which demonstrate excellent performance in toxicity prediction. However, these methods also have some defects, such as over-reliance on artificial features and easy overfitting, etc. Proposing novel models with superior prediction performance is still an urgent task. In this study, we propose a motifs-level graph-based multi-view pretraining language model, called 3MTox, for toxicity identification. The 3MTox model uses Bidirectional Encoder Representations from Transformers (BERT) as the backbone framework, and a motif graph as input. The results of extensive experiments showed that our 3MTox model achieved state-of-the-art performance on toxicity benchmark datasets and outperformed the baseline models considered. In addition, the interpretability of the model ensures that the it can quickly and accurately identify toxicity sites in a given molecule, thereby contributing to the determination of the status of toxicity and associated analyses. We think that the 3MTox model is among the most promising tools that are currently available for toxicity identification.

Automatic uncovering of patient primary concerns in portal messages using a fusion framework of pretrained language models.

OBJECTIVES: The surge in patient portal messages (PPMs) with increasing needs and workloads for efficient PPM triage in healthcare settings has spurred the exploration of AI-driven solutions to streamline the healthcare workflow processes, ensuring timely responses to patients to satisfy their healthcare needs. However, there has been less focus on isolating and understanding patient primary concerns in PPMs-a practice which holds the potential to yield more nuanced insights and enhances the quality of healthcare delivery and patient-centered care. MATERIALS AND METHODS: We propose a fusion framework to leverage pretrained language models (LMs) with different language advantages via a Convolution Neural Network for precise identification of patient primary concerns via multi-class classification. We examined 3 traditional machine learning models, 9 BERT-based language models, 6 fusion models, and 2 ensemble models. RESULTS: The outcomes of our experimentation underscore the superior performance achieved by BERT-based models in comparison to traditional machine learning models. Remarkably, our fusion model emerges as the top-performing solution, delivering a notably improved accuracy score of 77.67 ± 2.74% and an F1 score of 74.37 ± 3.70% in macro-average. DISCUSSION: This study highlights the feasibility and effectiveness of multi-class classification for patient primary concern detection and the proposed fusion framework for enhancing primary concern detection. CONCLUSIONS: The use of multi-class classification enhanced by a fusion of multiple pretrained LMs not only improves the accuracy and efficiency of patient primary concern identification in PPMs but also aids in managing the rising volume of PPMs in healthcare, ensuring critical patient communications are addressed promptly and accurately.

Coreference Resolution Based on High-Dimensional Multi-Scale Information.

Coreference resolution is a key task in Natural Language Processing. It is difficult to evaluate the similarity of long-span texts, which makes text-level encoding somewhat challenging. This paper first compares the impact of commonly used methods to improve the global information collection ability of the model on the BERT encoding performance. Based on this, a multi-scale context information module is designed to improve the applicability of the BERT encoding model under different text spans. In addition, improving linear separability through dimension expansion. Finally, cross-entropy loss is used as the loss function. After adding BERT and span BERT to the module designed in this article, F1 increased by 0.5% and 0.2%, respectively.

A novel model for relation prediction in knowledge graphs exploiting semantic and structural feature integration.

Relation prediction is a critical task in knowledge graph completion and associated downstream tasks that rely on knowledge representation. Previous studies indicate that both structural features and semantic information are meaningful for predicting missing relations in knowledge graphs. This has led to the development of two types of methods: structure-based methods and semantics-based methods. Since these two approaches represent two distinct learning paradigms, it is difficult to fully utilize both sets of features within a single learning model, especially deep features. As a result, existing studies usually focus on only one type of feature. This leads to an insufficient representation of knowledge in current methods and makes them prone to overlooking certain patterns when predicting missing relations. In this study, we introduce a novel model, RP-ISS, which combines deep semantic and structural features for relation prediction. The RP-ISS model utilizes a two-part architecture, with the first component being a RoBERTa module that is responsible for extracting semantic features from entity nodes. The second part of the system employs an edge-based relational message-passing network designed to capture and interpret structural information within the data. To alleviate the computational burden of the message-passing network on the RoBERTa module during the sampling process, RP-ISS introduces a node embedding memory bank, which updates asynchronously to circumvent excessive computation. The model was assessed on three publicly accessible datasets (WN18RR, WN18, and FB15k-237), and the results revealed that RP-ISS surpasses all baseline methods across all evaluation metrics. Moreover, RP-ISS showcases robust performance in graph inductive learning.

A novel framework based on explainable AI and genetic algorithms for designing neurological medicines.

The advent of the fourth industrial revolution, characterized by artificial intelligence (AI) as its central component, has resulted in the mechanization of numerous previously labor-intensive activities. The use of in silico tools has become prevalent in the design of biopharmaceuticals. Upon conducting a comprehensive analysis of the genomes of many organisms, it has been discovered that their tissues can generate specific peptides that confer protection against certain diseases. This study aims to identify a selected group of neuropeptides (NPs) possessing favorable characteristics that render them ideal for production as neurological biopharmaceuticals. Until now, the construction of NP classifiers has been the primary focus, neglecting to optimize these characteristics. Therefore, in this study, the task of creating ideal NPs has been formulated as a multi-objective optimization problem. The proposed framework, NPpred, comprises two distinct components: NSGA-NeuroPred and BERT-NeuroPred. The former employs the NSGA-II algorithm to explore and change a population of NPs, while the latter is an interpretable deep learning-based model. The utilization of explainable AI and motifs has led to the proposal of two novel operators, namely p-crossover and p-mutation. An online application has been deployed at https://neuropred.anvil.app for designing an ideal collection of synthesizable NPs from protein sequences.

Pre-trained language models in medicine: A survey.

With the rapid progress in Natural Language Processing (NLP), Pre-trained Language Models (PLM) such as BERT, BioBERT, and ChatGPT have shown great potential in various medical NLP tasks. This paper surveys the cutting-edge achievements in applying PLMs to various medical NLP tasks. Specifically, we first brief PLMS and outline the research of PLMs in medicine. Next, we categorise and discuss the types of tasks in medical NLP, covering text summarisation, question-answering, machine translation, sentiment analysis, named entity recognition, information extraction, medical education, relation extraction, and text mining. For each type of task, we first provide an overview of the basic concepts, the main methodologies, the advantages of applying PLMs, the basic steps of applying PLMs application, the datasets for training and testing, and the metrics for task evaluation. Subsequently, a summary of recent important research findings is presented, analysing their motivations, strengths vs weaknesses, similarities vs differences, and discussing potential limitations. Also, we assess the quality and influence of the research reviewed in this paper by comparing the citation count of the papers reviewed and the reputation and impact of the conferences and journals where they are published. Through these indicators, we further identify the most concerned research topics currently. Finally, we look forward to future research directions, including enhancing models' reliability, explainability, and fairness, to promote the application of PLMs in clinical practice. In addition, this survey also collect some download links of some model codes and the relevant datasets, which are valuable references for researchers applying NLP techniques in medicine and medical professionals seeking to enhance their expertise and healthcare service through AI technology.

End-to-end pseudonymization of fine-tuned clinical BERT models : Privacy preservation with maintained data utility.

Many state-of-the-art results in natural language processing (NLP) rely on large pre-trained language models (PLMs). These models consist of large amounts of parameters that are tuned using vast amounts of training data. These factors cause the models to memorize parts of their training data, making them vulnerable to various privacy attacks. This is cause for concern, especially when these models are applied in the clinical domain, where data are very sensitive. Training data pseudonymization is a privacy-preserving technique that aims to mitigate these problems. This technique automatically identifies and replaces sensitive entities with realistic but non-sensitive surrogates. Pseudonymization has yielded promising results in previous studies. However, no previous study has applied pseudonymization to both the pre-training data of PLMs and the fine-tuning data used to solve clinical NLP tasks. This study evaluates the effects on the predictive performance of end-to-end pseudonymization of Swedish clinical BERT models fine-tuned for five clinical NLP tasks. A large number of statistical tests are performed, revealing minimal harm to performance when using pseudonymized fine-tuning data. The results also find no deterioration from end-to-end pseudonymization of pre-training and fine-tuning data. These results demonstrate that pseudonymizing training data to reduce privacy risks can be done without harming data utility for training PLMs.

Large language models in psychiatry: Opportunities and challenges.

The ability of Large Language Models (LLMs) to analyze and respond to freely written text is causing increasing excitement in the field of psychiatry; the application of such models presents unique opportunities and challenges for psychiatric applications. This review article seeks to offer a comprehensive overview of LLMs in psychiatry, their model architecture, potential use cases, and clinical considerations. LLM frameworks such as ChatGPT/GPT-4 are trained on huge amounts of text data that are sometimes fine-tuned for specific tasks. This opens up a wide range of possible psychiatric applications, such as accurately predicting individual patient risk factors for specific disorders, engaging in therapeutic intervention, and analyzing therapeutic material, to name a few. However, adoption in the psychiatric setting presents many challenges, including inherent limitations and biases in LLMs, concerns about explainability and privacy, and the potential damage resulting from produced misinformation. This review covers potential opportunities and limitations and highlights potential considerations when these models are applied in a real-world psychiatric context.

A BERT-based pretraining model for extracting molecular structural information from a SMILES sequence.

Among the various molecular properties and their combinations, it is a costly process to obtain the desired molecular properties through theory or experiment. Using machine learning to analyze molecular structure features and to predict molecular properties is a potentially efficient alternative for accelerating the prediction of molecular properties. In this study, we analyze molecular properties through the molecular structure from the perspective of machine learning. We use SMILES sequences as inputs to an artificial neural network in extracting molecular structural features and predicting molecular properties. A SMILES sequence comprises symbols representing molecular structures. To address the problem that a SMILES sequence is different from actual molecular structural data, we propose a pretraining model for a SMILES sequence based on the BERT model, which is widely used in natural language processing, such that the model learns to extract the molecular structural information contained in the SMILES sequence. In an experiment, we first pretrain the proposed model with 100,000 SMILES sequences and then use the pretrained model to predict molecular properties on 22 data sets and the odor characteristics of molecules (98 types of odor descriptor). The experimental results show that our proposed pretraining model effectively improves the performance of molecular property prediction SCIENTIFIC CONTRIBUTION: The 2-encoder pretraining is proposed by focusing on the lower dependency of symbols to the contextual environment in a SMILES than one in a natural language sentence and the corresponding of one compound to multiple SMILES sequences. The model pretrained with 2-encoder shows higher robustness in tasks of molecular properties prediction compared to BERT which is adept at natural language.

Extracting patient lifestyle characteristics from Dutch clinical text with BERT models.

BACKGROUND: BERT models have seen widespread use on unstructured text within the clinical domain. However, little to no research has been conducted into classifying unstructured clinical notes on the basis of patient lifestyle indicators, especially in Dutch. This article aims to test the feasibility of deep BERT models on the task of patient lifestyle classification, as well as introducing an experimental framework that is easily reproducible in future research. METHODS: This study makes use of unstructured general patient text data from HagaZiekenhuis, a large hospital in The Netherlands. Over 148 000 notes were provided to us, which were each automatically labelled on the basis of the respective patients' smoking, alcohol usage and drug usage statuses. In this paper we test feasibility of automatically assigning labels, and justify it using hand-labelled input. Ultimately, we compare macro F1-scores of string matching, SGD and several BERT models on the task of classifying smoking, alcohol and drug usage. We test Dutch BERT models and English models with translated input. RESULTS: We find that our further pre-trained MedRoBERTa.nl-HAGA model outperformed every other model on smoking (0.93) and drug usage (0.77). Interestingly, our ClinicalBERT model that was merely fine-tuned on translated text performed best on the alcohol task (0.80). In t-SNE visualisations, we show our MedRoBERTa.nl-HAGA model is the best model to differentiate between classes in the embedding space, explaining its superior classification performance. CONCLUSIONS: We suggest MedRoBERTa.nl-HAGA to be used as a baseline in future research on Dutch free text patient lifestyle classification. We furthermore strongly suggest further exploring the application of translation to input text in non-English clinical BERT research, as we only translated a subset of the full set and yet achieved very promising results.

ShallowBKGC: a BERT-enhanced shallow neural network model for knowledge graph completion.

Knowledge graph completion aims to predict missing relations between entities in a knowledge graph. One of the effective ways for knowledge graph completion is knowledge graph embedding. However, existing embedding methods usually focus on developing deeper and more complex neural networks, or leveraging additional information, which inevitably increases computational complexity and is unfriendly to real-time applications. In this article, we propose an effective BERT-enhanced shallow neural network model for knowledge graph completion named ShallowBKGC. Specifically, given an entity pair, we first apply the pre-trained language model BERT to extract text features of head and tail entities. At the same time, we use the embedding layer to extract structure features of head and tail entities. Then the text and structure features are integrated into one entity-pair representation via average operation followed by a non-linear transformation. Finally, based on the entity-pair representation, we calculate probability of each relation through multi-label modeling to predict relations for the given entity pair. Experimental results on three benchmark datasets show that our model achieves a superior performance in comparison with baseline methods. The source code of this article can be obtained from https://github.com/Joni-gogogo/ShallowBKGC.

Deep-GenMut: Automated genetic mutation classification in oncology: A deep learning comparative study.

Early cancer detection and treatment depend on the discovery of specific genes that cause cancer. The classification of genetic mutations was initially done manually. However, this process relies on pathologists and can be a time-consuming task. Therefore, to improve the precision of clinical interpretation, researchers have developed computational algorithms that leverage next-generation sequencing technologies for automated mutation analysis. This paper utilized four deep learning classification models with training collections of biomedical texts. These models comprise bidirectional encoder representations from transformers for Biomedical text mining (BioBERT), a specialized language model implemented for biological contexts. Impressive results in multiple tasks, including text classification, language inference, and question answering, can be obtained by simply adding an extra layer to the BioBERT model. Moreover, bidirectional encoder representations from transformers (BERT), long short-term memory (LSTM), and bidirectional LSTM (BiLSTM) have been leveraged to produce very good results in categorizing genetic mutations based on textual evidence. The dataset used in the work was created by Memorial Sloan Kettering Cancer Center (MSKCC), which contains several mutations. Furthermore, this dataset poses a major classification challenge in the Kaggle research prediction competitions. In carrying out the work, three challenges were identified: enormous text length, biased representation of the data, and repeated data instances. Based on the commonly used evaluation metrics, the experimental results show that the BioBERT model outperforms other models with an F1 score of 0.87 and 0.850 MCC, which can be considered as improved performance compared to similar results in the literature that have an F1 score of 0.70 achieved with the BERT model.

Sentiment analysis of online reviews of energy-saving products based on transfer learning and LBBA model.

With the exacerbation of global climate change and the growing environmental awareness among the general public, the concept of green consumption has gained significant attention across various sectors of society. As a representative example of green consumer products, energy-saving products play a crucial role in the timely realization of dual carbon goals. However, an analysis of online comments regarding energy-saving products reveals that the majority of these products still exhibit shortcomings in terms of efficacy, noise level, cost-effectiveness, and particularly, energy-saving appliances. This study focuses on the user-generated online comments data from the Taobao e-commerce platform for Grade 1 energy-saving refrigerators. By employing text mining techniques, the study aims to extract the essential information and sentiments expressed in the comments, in order to explore the consumption characteristics of Grade 1 energy-saving refrigerators. Moreover, the LBBA (LDA-Bert-BiLSTM-Attention) model is utilized to investigate the consumer topics of interest and emotional features. Initially, the LDA model is adopted to identify the attributes and weights of consumer concerns. Subsequently, the Bert model is pre-trained with the online comment data, and combined with the BiLSTM algorithm and Attention mechanism to predict sentiment categories. Finally, a transfer learning approach is utilized to determine the sentiment inclination of user-generated online comments and to identify the primary driving factors behind each sentiment category. This research employs sentiment analysis on online comments data regarding energy-saving products to uncover consumer sentiment attributes and emotional characteristics. It provides decision-makers with a comprehensive and systematic understanding of public consumption intentions, offering decision support for the efficient operation and management of the energy-saving product market.

iDNA-OpenPrompt: OpenPrompt learning model for identifying DNA methylation.

Introduction: DNA methylation is a critical epigenetic modification involving the addition of a methyl group to the DNA molecule, playing a key role in regulating gene expression without changing the DNA sequence. The main difficulty in identifying DNA methylation sites lies in the subtle and complex nature of methylation patterns, which may vary across different tissues, developmental stages, and environmental conditions. Traditional methods for methylation site identification, such as bisulfite sequencing, are typically labor-intensive, costly, and require large amounts of DNA, hindering high-throughput analysis. Moreover, these methods may not always provide the resolution needed to detect methylation at specific sites, especially in genomic regions that are rich in repetitive sequences or have low levels of methylation. Furthermore, current deep learning approaches generally lack sufficient accuracy. Methods: This study introduces the iDNA-OpenPrompt model, leveraging the novel OpenPrompt learning framework. The model combines a prompt template, prompt verbalizer, and Pre-trained Language Model (PLM) to construct the prompt-learning framework for DNA methylation sequences. Moreover, a DNA vocabulary library, BERT tokenizer, and specific label words are also introduced into the model to enable accurate identification of DNA methylation sites. Results and Discussion: An extensive analysis is conducted to evaluate the predictive, reliability, and consistency capabilities of the iDNA-OpenPrompt model. The experimental outcomes, covering 17 benchmark datasets that include various species and three DNA methylation modifications (4mC, 5hmC, 6mA), consistently indicate that our model surpasses outstanding performance and robustness approaches.

Oversampling effect in pretraining for bidirectional encoder representations from transformers (BERT) to localize medical BERT and enhance biomedical BERT.

BACKGROUND: Pretraining large-scale neural language models on raw texts has made a significant contribution to improving transfer learning in natural language processing. With the introduction of transformer-based language models, such as bidirectional encoder representations from transformers (BERT), the performance of information extraction from free text has improved significantly in both the general and medical domains. However, it is difficult to train specific BERT models to perform well in domains for which few databases of a high quality and large size are publicly available. OBJECTIVE: We hypothesized that this problem could be addressed by oversampling a domain-specific corpus and using it for pretraining with a larger corpus in a balanced manner. In the present study, we verified our hypothesis by developing pretraining models using our method and evaluating their performance. METHODS: Our proposed method was based on the simultaneous pretraining of models with knowledge from distinct domains after oversampling. We conducted three experiments in which we generated (1) English biomedical BERT from a small biomedical corpus, (2) Japanese medical BERT from a small medical corpus, and (3) enhanced biomedical BERT pretrained with complete PubMed abstracts in a balanced manner. We then compared their performance with those of conventional models. RESULTS: Our English BERT pretrained using both general and small medical domain corpora performed sufficiently well for practical use on the biomedical language understanding evaluation (BLUE) benchmark. Moreover, our proposed method was more effective than the conventional methods for each biomedical corpus of the same corpus size in the general domain. Our Japanese medical BERT outperformed the other BERT models built using a conventional method for almost all the medical tasks. The model demonstrated the same trend as that of the first experiment in English. Further, our enhanced biomedical BERT model, which was not pretrained on clinical notes, achieved superior clinical and biomedical scores on the BLUE benchmark with an increase of 0.3 points in the clinical score and 0.5 points in the biomedical score. These scores were above those of the models trained without our proposed method. CONCLUSIONS: Well-balanced pretraining using oversampling instances derived from a corpus appropriate for the target task allowed us to construct a high-performance BERT model.

Coding with the machines: machine-assisted coding of rare event data.

While machine coding of data has dramatically advanced in recent years, the literature raises significant concerns about validation of LLM classification showing, for example, that reliability varies greatly by prompt and temperature tuning, across subject areas and tasks-especially in "zero-shot" applications. This paper contributes to the discussion of validation in several different ways. To test the relative performance of supervised and semi-supervised algorithms when coding political data, we compare three models' performances to each other over multiple iterations for each model and to trained expert coding of data. We also examine changes in performance resulting from prompt engineering and pre-processing of source data. To ameliorate concerns regarding LLM's pre-training on test data, we assess performance by updating an existing dataset beyond what is publicly available. Overall, we find that only GPT-4 approaches trained expert coders when coding contexts familiar to human coders and codes more consistently across contexts. We conclude by discussing some benefits and drawbacks of machine coding moving forward.

Evaluating the accuracy of a state-of-the-art large language model for prediction of admissions from the emergency room.

BACKGROUND: Artificial intelligence (AI) and large language models (LLMs) can play a critical role in emergency room operations by augmenting decision-making about patient admission. However, there are no studies for LLMs using real-world data and scenarios, in comparison to and being informed by traditional supervised machine learning (ML) models. We evaluated the performance of GPT-4 for predicting patient admissions from emergency department (ED) visits. We compared performance to traditional ML models both naively and when informed by few-shot examples and/or numerical probabilities. METHODS: We conducted a retrospective study using electronic health records across 7 NYC hospitals. We trained Bio-Clinical-BERT and XGBoost (XGB) models on unstructured and structured data, respectively, and created an ensemble model reflecting ML performance. We then assessed GPT-4 capabilities in many scenarios: through Zero-shot, Few-shot with and without retrieval-augmented generation (RAG), and with and without ML numerical probabilities. RESULTS: The Ensemble ML model achieved an area under the receiver operating characteristic curve (AUC) of 0.88, an area under the precision-recall curve (AUPRC) of 0.72 and an accuracy of 82.9%. The naïve GPT-4's performance (0.79 AUC, 0.48 AUPRC, and 77.5% accuracy) showed substantial improvement when given limited, relevant data to learn from (ie, RAG) and underlying ML probabilities (0.87 AUC, 0.71 AUPRC, and 83.1% accuracy). Interestingly, RAG alone boosted performance to near peak levels (0.82 AUC, 0.56 AUPRC, and 81.3% accuracy). CONCLUSIONS: The naïve LLM had limited performance but showed significant improvement in predicting ED admissions when supplemented with real-world examples to learn from, particularly through RAG, and/or numerical probabilities from traditional ML models. Its peak performance, although slightly lower than the pure ML model, is noteworthy given its potential for providing reasoning behind predictions. Further refinement of LLMs with real-world data is necessary for successful integration as decision-support tools in care settings.

Automating Fault Test Cases Generation and Execution for Automotive Safety Validation via NLP and HIL Simulation.

The complexity and the criticality of automotive electronic implanted systems are steadily advancing and that is especially the case for automotive software development. ISO 26262 describes requirements for the development process to confirm the safety of such complex systems. Among these requirements, fault injection is a reliable technique to assess the effectiveness of safety mechanisms and verify the correct implementation of the safety requirements. However, the method of injecting the fault in the system under test in many cases is still manual and depends on an expert, requiring a high level of knowledge of the system. In complex systems, it consumes time, is difficult to execute, and takes effort, because the testers limit the fault injection experiments and inject the minimum number of possible test cases. Fault injection enables testers to identify and address potential issues with a system under test before they become actual problems. In the automotive industry, failures can have serious hazards. In these systems, it is essential to ensure that the system can operate safely even in the presence of faults. We propose an approach using natural language processing (NLP) technologies to automatically derive the fault test cases from the functional safety requirements (FSRs) and execute them automatically by hardware-in-the-loop (HIL) in real time according to the black-box concept and the ISO 26262 standard. The approach demonstrates effectiveness in automatically identifying fault injection locations and conditions, simplifying the testing process, and providing a scalable solution for various safety-critical systems.