Optically stimulated luminescence detectors for dosimetry and LET measurements in light ion beams.

Objective.This work investigates the use of Al2O3:C and Al2O3:C,Mg optically stimulated luminescence (OSL) detectors to determine both the dose and the radiation quality in light ion beams. The radiation quality is here expressed through either the linear energy transfer (LET) or the closely related metricQeff, which depends on the particle's speed and effective charge. The derived LET andQeffvalues are applied to improve the dosimetry in light ion beams.Approach.OSL detectors were irradiated in mono-energetic1H-,4He-,12C-, and16O-ion beams. The OSL signal is associated with two emission bands that were separated using a pulsed stimulation technique and subjected to automatic corrections based on reference irradiations. Each emission band was investigated independently for dosimetry, and the ratio of the two emission intensities was parameterized as a function of fluence- and dose-averaged LET, as well asQeff. The determined radiation quality was subsequently applied to correct the dose for ionization quenching.Main results.For both materials, theQeffdeterminations in1H- and4He-ion beams are within 5 % of the Monte Carlo simulated values. Using the determined radiation quality metrics to correct the nonlinear (ionization quenched) detector response leads to doses within 2 % of the reference doses.Significance.Al2O3:C and Al2O3:C,Mg OSL detectors are applicable for dosimetry and radiation quality estimations in1H- and4He-ions. Only Al2O3:C,Mg shows promising results for dosimetry in12C-ions. Across both materials and the investigated ions, the estimatedQeffvalues were less sensitive to the ion types than the estimated LET values were. The reduced uncertainties suggest new possibilities for simultaneously estimating the physical and biological dose in particle therapy with OSL detectors.

A real-time method to simultaneously measure linear energy transfer and dose for proton therapy using organic scintillators.

PURPOSE: Currently, no detectors are capable of simultaneously measuring dose and linear energy transfer (LET) in real time. In this study, we evaluated the feasibility of exploiting the difference in the response of various organic plastic scintillation detectors to measure LET and dose in therapeutic proton beams. The hypothesis behind this work was that the ratio of the responses of different scintillators exposed to the same proton beam can be used to obtain a LET vs ratio calibration curve that can then be used to infer LET under any other measurement conditions. METHODS: We first used similar scintillators with different ionization quenching factors. LET values for different irradiation conditions were calculated using a validated Monte Carlo model of the proton beam line. The quenching factors in the Birks equation for different scintillators as a function of LET were obtained from measurements in a 100-MeV pristine proton beam. We then used four different organic scintillation materials - polystyrene (BCF-12), poly (methyl methacrylate), polyvinyltoluene, and a liquid scintillator - for which the LET response varied with regard to not only quenching but also differences in material density and relative stopping power. We simultaneously exposed the four different organic scintillators and a plane-parallel ion chamber to passively scattered proton beams at fluence-averaged LET. Comparisons to the expected values obtained from the Monte Carlo simulations were made on the basis of both dose and LET. RESULTS: The maximum difference in the quenching factor was 20%, resulting in a 5% change in LET with a response ratio over a range of 5 keV/µm. Among all the scintillators investigated, the ratio of PMMA to BCF-12 provided the best correlation with LET values and was therefore used to construct the LET calibration curve. The expected LET values in the validation set were within 2% ± 6%, which resulted in dose accuracy of 1.5% ± 5.8% for the range of LET values investigated in this work. CONCLUSIONS: We demonstrated the feasibility of using the ratio of the light outputs of two organic scintillators to simultaneously measure LET and dose in therapeutic proton beams for fluence-averaged LET values from 0.47 to 1.26 keV/µm. Further studies are needed to verify the response for higher LET values and the reproducibility of this method.

Extension of the TDCR model to compute counting efficiencies for radionuclides with complex decay schemes.

The triple-to-double coincidence ratio (TDCR) method is frequently used to measure the activity of radionuclides decaying by pure ß emission or electron capture (EC). Some radionuclides with more complex decays have also been studied, but accurate calculations of decay branches which are accompanied by many coincident γ transitions have not yet been investigated. This paper describes recent extensions of the model to make efficiency computations for more complex decay schemes possible. In particular, the MICELLE2 program that applies a stochastic approach of the free parameter model was extended. With an improved code, efficiencies for ß(-), ß(+) and EC branches with up to seven coincident γ transitions can be calculated. Moreover, a new parametrization for the computation of electron stopping powers has been implemented to compute the ionization quenching function of 10 commercial scintillation cocktails. In order to demonstrate the capabilities of the TDCR method, the following radionuclides are discussed: (166m)Ho (complex ß(-)/γ), (59)Fe (complex ß(-)/γ), (64)Cu (ß(-), ß(+), EC and EC/γ) and (229)Th in equilibrium with its progenies (decay chain with many α, ß and complex ß(-)/γ transitions).