Vertebral Angiomatosis in a Dog.

A 3 yr old spayed female Cavalier King Charles spaniel was referred for insidious ataxia and paraparesis. A thoracolumbar lesion was suspected. Computed tomography showed focal osteolysis of the vertebral body and pedicles of T5. In addition, a hyperdense, extradural material within the vertebral canal, causing spinal cord compression on the right side, was present. The lesion was confirmed with magnetic resonance imaging. A T4-T5 hemi-dorsal laminectomy was performed to decompress the spinal cord. Histopathological examination was consistent with vertebral angiomatosis. After the surgery, the dog rapidly improved; however, 5 mo later the clinical signs relapsed. Vertebral angiomatosis is a vasoproliferative disorder, rarely reported as a cause of myelopathy in cats. This condition has not previously been reported in dogs. This case report describes the clinical features, the diagnostic findings, and the follow-up of a young dog with vertebral angiomatosis.

Equine small intestinal angiomatosis.

Multiple red, raised nodules multifocally distributed along the serosal surface of the normal and the nonviable jejunum were identified in a 24-year-old neutered male horse undergoing surgery for removal of the strangulating lipoma around the jejunum. Histologically, these nodules consisted of many significantly and variably dilated, blood-filled vascular channels lined by a single layer of flattened, well-differentiated endothelial cells with occasional thrombi within a mildly thickened fibrous stroma. A diagnosis of intestinal angiomatosis was proposed. To the best of the authors' knowledge, this is the second report of small intestinal angiomatosis in a horse.

Angiomatose du petit intestin équin. De multiples nodules rouges surélevés distribués de manière multifocale le long de la surface séreuse du jéjunum viable et non-viable furent identifiés chez un cheval mâle castré âgé de 24 ans soumis à une chirurgie pour le retrait d'un lipome étranglant autour du jéjunum. Histologiquement, ces nodules consistaient en de nombreux canaux vasculaires remplis de sang dilatés de manière significative et variable, et tapissés par une couche unique de cellules endothéliales aplaties et bien différenciées avec à l'occasion des thrombi à l'intérieur d'un stroma fibreux légèrement épaissi. Un diagnostic d'angiomatose intestinale fut proposé. Au meilleur de la connaissance des auteurs, ceci constitue le deuxième rapport d'angiomatose du petit intestin chez un cheval.(Traduit par Dr Serge Messier).

Progressive cutaneous angiomatosis in the metatarsal region of a cat.

CASE DESCRIPTION: A 1.5-year-old 4.0-kg (8.8-lb) castrated male mixed-breed cat was evaluated because of an 8-month history of repeated bleeding from a hole in the skin next to the left metatarsal pad. CLINICAL FINDINGS: The cat had swelling in the distal region of the left pelvic limb, and blood dripped from a 2-mm-diameter hole in the skin adjacent and proximal to the metatarsal pad. Radiographic findings for the distal aspect of the left pelvic limb were compatible with a soft tissue inflammatory process. Results of histologic examination of a wedge biopsy sample, including the affected skin and subcutaneous tissue, indicated cutaneous angiomatosis. Angiography revealed anomalous vessels in the metatarsal region. TREATMENT AND OUTCOME: Surgical resection of the skin, subcutaneous tissue, and anomalous vessels in the affected metatarsal region of the left pelvic limb was performed. However, similar abnormal clinical signs recurred and did not respond to treatment, including prednisolone (2.0 mg/kg [0.9 mg/lb], PO, q 12 h for 4 days) and doxycycline (10 mg/kg [4.5 mg/lb], PO, q 24 h). The left pelvic limb was amputated, and no recurrence of similar abnormalities in the cat's other limbs was evident within a 15-month follow-up period. CLINICAL RELEVANCE: Findings in the cat of the present report highlighted that cutaneous angiomatosis could recur in a short period of time and that amputation of the affected limb was a viable treatment option when surgical resection was not successful.

Radiation therapy for the treatment of canine progressive cutaneous angiomatosis: Description of 2 cases.

Two dogs with histologically confirmed progressive cutaneous angiomatosis were presented because of extensive and progressive cutaneous lesions of 1 hind limb causing pain and lameness. Radiation therapy was offered to treat disease recurrence after amputation in the first case and as first treatment in the second case. Metronomic therapy was added in both dogs. Complete and partial regression of the cutaneous lesions was achieved, respectively, with a period of 31 months of disease-free interval (first case) and 12 months of stable disease (second case). Self-limiting grades I and II acute side effects were observed. Radiation therapy can be an alternative to surgery in the treatment of inoperable cutaneous progressive angiomatosis.

Radiothérapie pour le traitement de l'angiomatose cutanée progressive canine : description de 2 cas. Deux chiens ayant un diagnostic d'angiomatose cutanée progressive confirmé par histologie ont été présentés en raison de lésions cutanées vastes et progressives d'un membre postérieur qui causaient de la douleur et de la boiterie. La radiothérapie a été offerte pour traiter la récidive de la maladie après l'amputation dans le premier cas et comme premier traitement dans le deuxième cas. La thérapie métronomique a été ajoutée chez les deux chiens. Une régression complète et partielle des lésions cutanées a été obtenue, respectivement, avec un intervalle de 31 mois sans maladie (premier cas) et de 12 mois de maladie stable (deuxième cas). Des effets secondaires aigus spontanément résolutifs de grades I et II ont été observés. La radiothérapie peut représenter un traitement de remplacement à la chirurgie pour le traitement de l'angiomatose cutanée progressive inopérable.(Traduit par Isabelle Vallières).

Long-term outcome following surgical and radiation treatment of vertebral angiomatosis in a cat.

CASE DESCRIPTION A 2-year-old 5.2-kg (11.4-lb) neutered male domestic shorthair cat was referred because of a 6-week history of progressive paraparesis. CLINICAL FINDINGS Neurologic examination revealed moderate ambulatory paraparesis with marked spinal hyperesthesia at the thoracolumbar junction. The lesion was localized to the T3-L3 spinal cord segment. Clinicopathologic testing, thoracic radiography, and abdominal ultrasonography revealed no abnormalities to explain the observed clinical signs. Advanced spinal imaging with MRI revealed an extradural right-lateralized mass originating from the L2 vertebral pedicle and causing severe spinal cord compression. TREATMENT AND OUTCOME Surgical decompression was achieved by performance of a right-sided hemilaminectomy at L2. Histologic examination of biopsy samples obtained from the mass revealed an ill-defined zone of mature vascular proliferation extending through the preexisting vertebral bone, consistent with vertebral angiomatosis. After surgical recovery, adjuvant radiation therapy was initiated with a total dose of 48 Gy administered in 16 fractions of 3 Gy each over a 3-week period. Neurologic function rapidly improved to full ambulation with only minimal monoparesis of the right pelvic limb. Results of neurologic and MRI examination performed 26 months after surgery indicated no change in neurologic status or evidence of recurrence. CLINICAL RELEVANCE To the authors' knowledge, this report was the first to describe the long-term outcome for vertebral angiomatosis in a cat. Surgical decompression and radiation therapy provided an excellent outcome in this case. Vertebral angiomatosis should be considered as a differential diagnosis for any young cat with thoracolumbar myelopathy secondary to a mass associated with the vertebral pedicle.

Spontaneous progression of cutaneous angiomatosis to an infiltrative sarcoma-like tumour in a bull.

CASE HISTORY: A 5-month-old valuable Red Holstein bull presented with a cutaneous mass on the fetlock of the right hind limb. The mass was removed and histologically diagnosed as a benign angiomatosis. Four months later, the mass reoccurred on the same leg. PATHOLOGICAL FINDINGS: The first excision biopsy consisted of numerous blood vessels of different diameters and wall thicknesses. Often, the smaller vessels were oriented around a larger, vein-like vessel. The endothelial cells were elongated with small oval to elongated nuclei with dense chromatin. Following recurrence, the mass showed clear signs of infiltrative growth, including solid bundles of cells, increased polymorphism and round to oval nuclei with coarse chromatin and distinctive nucleoli. The neoplastic cells were immunohistochemically positive for von Willebrand Factor (vWF). DIAGNOSIS: Angiomatosis with focal progression to an infiltrative growing sarcoma-like tumour. CLINICAL RELEVANCE: This case represents the progression of a benign vascular proliferation, often considered as a reactive process, into a more aggressively behaving neoplasm. The clinical behaviour and histopathological morphology were strikingly similar to previous cases described in human and veterinary medicine.

Bacterial sepsis resulting in severe systemic illness and euthanasia in a dog with cutaneous angiomatosis.

A Labrador retriever dog was euthanized after unsuccessful treatment for severe, progressive, lethargy, gastroenteritis, icterus, and swelling of a previously diagnosed cutaneous angiomatosis lesion. The body was submitted for necropsy. This is the first report that suggests that cutaneous angiomatosis lesions may have caused life-threatening systemic complications in a dog.

Septicémie bactérienne produisant une maladie systémique grave et l'euthanasie chez un chien atteint d'angiomatose cutanée. Un chien Labrador retriever a été euthanasié après l'échec du traitement pour un abattement sévère progressif, une gastro-entérite, l'ictère et l'enflure d'une lésion d'angiomatose cutanée diagnostiquée antérieurement. Le corps a été soumis à l'autopsie. C'est le premier rapport qui suggère que les lésions d'angiomatose cutanée peuvent avoir causé des complications systémiques potentiellement mortelles chez un chien.(Traduit par Isabelle Vallières).

Multi-system progressive angiomatosis in a dog resembling blue rubber bleb nevus syndrome in humans.

A six-year-old, neutered, female golden retriever was presented with generalised, dark purple to black cutaneous nodules and gastrointestinal haemorrhage. Histopathologically, all cutaneous nodules were diagnosed as benign cavernous haemangiomas. Endoscopic analysis revealed similar nodules in the oesophagus, stomach and duodenum. At laparotomy, similar nodules were seen on the visceral peritoneal lining of abdominal organs. Metastatic haemangiosarcoma was ruled out based on histological features and lack of primary tumour in spleen, liver or heart ultrasonographically. Blood loss associated with gastrointestinal haemorrhage was managed with blood transfusion. To the authors' knowledge, this is the first canine case of multi-system progressive angiomatosis resembling blue rubber bleb nevus syndrome in humans.

Thalamic astrocytic hamartoma and associated meningoangiomatosis in a German shepherd dog.

The present paper describes an astrocytic thalamic hamartoma associated with tectal meningoangiomatosis in a 3-month-old female German shepherd dog showing strabismus, opistotonus, circling, and fore limb hypermetria. MR images of the brain showed a well-defined intra-axial mass in the tectal region. The mass was hypointense to gray matter on T2-weighted images and hyperintense to gray matter on precontrast T1-weighted images. Histologically, glial cells arranged in a multinodular pattern characterized the mass. More caudally the lesion merged with subpial abnormal newly formed plaque-like shaped tissue characterized by thick branching bundles of spindle-shaped cells surrounding a central vessel. In the nodules, GFAP and vimentin were diffusely expressed. In the vascular proliferation Factor VIII-positive reaction was limited to endothelial cells while the remaining spindle-shaped cells were diffusely SMA-positive. The glial nodules did not express lysozyme and MAC387, nor neurofilaments and nestin.

Pulmonary angiomatosis and hemangioma in common dolphins (Delphinus delphis) stranded in Canary Islands.

Vascular tumors and disorders, like angiomatosis, are rarely described in cetacean species. A retrospective histological study was carried out on lung samples from 35 common dolphins (Delphinus delphis) stranded in the Canary Islands coasts looking for morphological vascular changes and likely related causes. Twenty-five out of thirty-five (71%) common dolphins showed focal or multifocal angiomatosis-like lesions. A high association between this type of vascular proliferation and parasitic infestation was observed. In addition, a single pulmonary cavernous hemangioma not previously reported in common dolphins is presented.

Skeletal-extraskeletal angiomatosis in a dog.

An 8-year-old castrated male mixed-breed dog had an ill-defined hemorrhagic and painful lesion in the base of the claw of the second digit of the right forelimb. Radiographically, the expansile and lytic lesion affected the distal phalanx. The digit was amputated and submitted for histologic examination. Histologically, the distal phalanx was largely replaced by a mass composed of variably sized cavernous vascular spaces lined by a single layer of flattened endothelial cells. A similar mass was in the subcutis adjacent to the distal phalanx. The benign vascular proliferation involving the medulla of bone and a second tissue type in this dog is consistent with skeletal-extraskeletal angiomatosis as described in humans. To the authors' knowledge, this is the first report of skeletal-extraskeletal angiomatosis in the veterinary literature.

Cutaneous progressive angiomatosis on the muzzle of a dog, treated by laser photocoagulation therapy.

A 10-year old, female, cocker spaniel was presented with a bleeding lesion on the muzzle and nasal planum observed initially as a small raised nodule at 1 year of age. This became clinically more pronounced at 5 years of age, progressively enlarged thereafter and was diagnosed initially as a vascular tumour. On clinical examination, multiple confluent nodules of variable diameter (0.5-1.5 cm) deformed the outline of the nose. Histological examination revealed a progressive angiomatosis with multifocal infiltrative growth of increased dermal vascularization with different sized and type of anastomosing vessels lined by a monolayer of reactive endothelium, often arranged as papillary projections into the lumina. Partial nosectomy, the first therapeutic approach, was unsuccessful and the lesion relapsed within 6 months. However, subsequent laser photocoagulation therapy provided a good cosmetic outcome, no relapse 1 year later, and appeared to provide an effective alternative to ablation surgery.

Spinal cord compression in a cat due to vertebral angiomatosis.

A 1-year-old cat was presented with general discomfort but no neurologic deficits on physical examination. An extradural spinal cord compression at the level of T10-11 and T11-12 was evident on myelography and computed tomography examination. Hemilaminectomy was performed to decompress the spinal cord. Histopathology of the abnormal pedicle and lamina revealed vertebral angiomatosis. This rare vascular malformation was the cause of the spinal cord compression in this cat. It is seen in cats less than 2 years of age and affected the thoracic spine in all four previously reported cases.

Cutaneous angiomatosis in a llama (Lama glama).

Cutaneous angiomatosis was diagnosed in an adult female llama (Lama glama). Lesions were raised or plaque-like, erythematous, firm to soft in consistency and were observed on the face and skin of the axillary, abdominal, perineal and inguinal regions. The lesions were not painful or pruritic. Microscopical examination revealed an irregular parakeratotic lamellar hyperkeratosis associated with diffuse proliferation of arterioles and venules in the superficial dermis. Immunohistochemical analysis determined that the cells forming these vessels and perivascular cells expressed factor VIII-related antigen, vascular endothelial growth factor (VEGF), CD31 and smooth-muscle alpha-actin. These studies confirmed the diagnosis of cutaneous angiomatosis.

Invasive cutaneous angiomatosis and thrombocytopenia in a cat.

CASE DESCRIPTION: A 9-year-old 6.9-kg (15.18-lb) castrated male Siamese cat was evaluated because of a 3-year history of repeated hemorrhage from the right metacarpal pad. CLINICAL FINDINGS: Physical examination findings were unremarkable except for a 2-mm-diameter erosion of the right metacarpal pad. A CBC revealed marked thrombocytopenia. Serum biochemical analyses, retroviral screening, thoracic radiography, and abdominal ultrasonography revealed no abnormalities. Via ultrasonographic examination, the vasculature in the right metacarpal pad appeared increased, compared with that of the left pad; an aberrant arterial plexus that was confined to the metacarpal pad was identified via arterial angiography. TREATMENT AND OUTCOME: Surgical resection of the metacarpal pad (without digital pad transposition) with primary closure was performed. Histologic evaluation of the pad tissue revealed invasive cutaneous angiomatosis. The incision healed without complications, and limb function was considered normal. Administration of prednisone (2 mg/kg [0.91 mg/lb], PO, q 24 h) was initiated 4 weeks prior to surgery to treat suspected immune-mediated thrombocytopenia and continued afterwards with a tapering dosage. Platelet count was within reference limits 4 months after surgery; at 12 months, there was no evidence of recurrence of abnormal vasculature in the right metacarpal pad region. CLINICAL RELEVANCE: Complete resection of the metacarpal pad (without pad transposition) resulted in successful and well-tolerated treatment of cutaneous angiomatosis of the metacarpal pad of a cat. Recurrence of abnormal vasculature was not evident at a 12-month follow-up examination. Thrombocytopenia is commonly associated with vascular anomalies in humans and may have been a contributing factor in this cat.

Cerebral meningioangiomatosis in a CD-1 mouse: a case report and comparison with humans and dogs.

Meningioangiomatosis is a rare proliferative disorder of the central nervous system. Several cases have been described in humans, a few in dogs, one case in a cow and one in a horse; meningioangiomatosis has never been recorded in rodents. The pathogenesis of this condition remains obscure and it is uncertain whether it represents a neoplastic or malformative process. Meningioangiomatosis is usually characterized by a plaque-like leptomeningeal proliferation of mainly spindle-shaped cells and small blood vessels, extending along the Virchow-Robin spaces into the adjacent neural parenchyma. In this report, we presented a brain lesion displaying the histopathological key features of the meningioangiomatosis and involving the base of the cerebrum (fronto-basal area) and the brainstem, found in a male CD-1 mouse. The histopathological and immunohistochemical results are discussed, and compared with those previously reported in other cases of meningioangiomatosis.

Ovarian and intestinal angiomatosis in a horse.

Dozens of red, raised nodules scattered along the serosal surface of the small intestine and the right and left ovaries were observed as incidental findings on gross examination in a 21-year-old Thoroughbred mare euthanatized for severe lameness. Histologically, these nodules were composed of numerous, variably sized, redundant vascular profiles filled with red blood cells and fibrin thrombi. Based on the presence of multiple nodules composed of benign vascular channels scattered within the small intestine and ovary, a diagnosis of angiomatosis is proposed. To the authors' knowledge, this is the first report of small intestinal and ovarian angiomatosis in a horse.

Cutaneous angiomatosis in a young dog.

A 1-year-old, spayed, female, mixed-breed dog had two reddish-purple cutaneous lesions, one on the right dorsal antebrachium and the other on the right shoulder. The lesions consisted of approximately 13 x 3 cm and 15 x 10 cm, irregular, patchy regions of 0.5-3.0 cm, circular, sometimes raised, reddish-purple swellings resembling ecchymoses. The lesion on the antebrachium had been noticed since the dog was adopted at 6 months of age and appeared to have increased in size over an 11-week period, at which time skin punch biopsy revealed an infiltrative pattern of well-differentiated blood vessels leading to an interpretation that the lesion was a well-differentiated hemangiosarcoma. The second lesion was revealed when the dog had its fur shaved in that area during surgical preparation to excise the antebrachial lesion. No other skin lesions were found on the dog. Microscopically, there was a widely disseminated and infiltrative-like pattern of benign-appearing small blood vessels, which were throughout the superficial and deep dermis and subcutis. Although the disseminated nature suggested malignancy, the histologic appearance of well-differentiated small blood vessels and nonprogressive clinical features indicate that the lesions were benign. The dog has been followed for 6 years and to date has no evidence of progression of the antebrachial lesion or shoulder lesion. To the authors' knowledge, this is the first report of a congenital angiomatosis-like lesion in a young dog, with extensive involvement of the forelimb.