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1.
Anticancer Res ; 44(7): 3205-3211, 2024 Jul.
Article in English | MEDLINE | ID: mdl-38925850

ABSTRACT

BACKGROUND/AIM: Complete surgical resection with negative margins remains the cornerstone for curative treatment of rectal cancer; however, local recurrence can pose a significant challenge. Herein, we aimed to introduce a novel surgical technique for combined resection of the pubic arch and ischial bone in the context of treating recurrent rectal cancer. CASE REPORT: We present a case of a patient with a fourth local recurrence of rectal cancer, with no evidence of distant metastasis. The tumor directly invaded the posterior wall of the pubic arch. To achieve complete tumor resection, an osteotomy was performed using a thread wire saw at the bilateral pubic rami and ischial bones. Intraoperative frozen section analysis (rapid tissue examination) was conducted on tissue samples from the lateral margins of the planned osteotomy line. Samples were negative for adenocarcinoma (cancerous cells). The combined resection of the pubic arch and ischial bone was successfully performed with negative margins for adenocarcinoma, as confirmed by frozen section analysis. CONCLUSION: Mastery of the surgical technique for combined resection of the pubic arch and ischial bone may be clinically significant for achieving complete resection in cases of multiple resections for locally recurrent rectal cancer.


Subject(s)
Ischium , Neoplasm Recurrence, Local , Pubic Bone , Rectal Neoplasms , Humans , Adenocarcinoma/surgery , Adenocarcinoma/pathology , Ischium/surgery , Ischium/pathology , Neoplasm Recurrence, Local/surgery , Neoplasm Recurrence, Local/pathology , Osteotomy/methods , Pubic Bone/surgery , Pubic Bone/pathology , Rectal Neoplasms/surgery , Rectal Neoplasms/pathology
2.
Clin Radiol ; 78(10): 724-729, 2023 10.
Article in English | MEDLINE | ID: mdl-37453806

ABSTRACT

The osseous pelvis is a well-known area of various primary and secondary bone tumours, tumour mimics, and infections. Isolated lesions of the pubis (ILP) are rare, with few case reports in the literature. Given their sparsity, such lesions may pose a great diagnostic challenge due to varied clinical presentations and imaging features. In this study, we report the largest case series of ILP. We discuss the patient demographics, differentials, surgical approaches, and management.


Subject(s)
Bone Neoplasms , Pubic Bone , Humans , Pubic Bone/pathology , Bone Neoplasms/diagnostic imaging , Bone Neoplasms/pathology , Pelvis
3.
Knee Surg Sports Traumatol Arthrosc ; 29(5): 1474-1482, 2021 May.
Article in English | MEDLINE | ID: mdl-33452578

ABSTRACT

PURPOSE: To investigate the prevalence of magnetic resonance imaging (MRI) findings and define prognostic factors of the return-to-play time in young athletes with groin pain. METHODS: A total of 1091 consecutive athletes were retrospectively screened; 651 athletes, aged 16-40 years, with pain in the groin regions were assessed using MRI. Of these athletes, 356 were included for analysing the time to return-to-play. Univariate and multiple linear regression analyses were used to determine the associations between the time to return-to-play (primary outcome variable) and the following variables: age, sex, body mass index, type of sports, Hip Sports Activity Scale, clear trauma history, and 12 MRI findings. RESULTS: Four MRI findings, including cleft sign, pubic bone marrow oedema of both the superior and inferior ramus, and central disc protrusion of the pubic symphysis, appeared together in more than 44% of the cases. The median time to return-to-play was 24.7 weeks for athletes with a cleft sign on MRI, which was significantly longer than the 11.9 weeks for athletes without the sign. The median time to return-to-play was 20.8 weeks for athletes with BMI > 24, which was significantly longer than the 13.6 weeks for athletes with BMI â‰¦ 24. In multiple linear regression analysis of 356 athletes, in whom hip-related groin pain was excluded, and who were followed-up until the return-to-play, the body mass index and cleft sign were the independent factors associated with a delayed return-to-play. In contrast, iliopsoas muscle strain and other muscle injuries were associated with a shorter return-to-play. CONCLUSIONS: Multiple MRI findings were present in almost half of all cases. Body mass index and the cleft sign were independently associated with a delayed return-to-play time in young athletes suffering from groin pain. LEVEL OF EVIDENCE: III.


Subject(s)
Athletic Injuries/diagnostic imaging , Groin/injuries , Magnetic Resonance Imaging/methods , Pain/diagnostic imaging , Return to Sport , Adolescent , Adult , Athletes , Bone Marrow/pathology , Edema/diagnosis , Edema/pathology , Female , Groin/diagnostic imaging , Humans , Linear Models , Male , Pain/pathology , Pubic Bone/pathology , Pubic Symphysis/diagnostic imaging , Pubic Symphysis/injuries , Retrospective Studies , Thigh/injuries , Young Adult
4.
Vet Surg ; 49(3): 614-620, 2020 Apr.
Article in English | MEDLINE | ID: mdl-31738458

ABSTRACT

OBJECTIVE: To report the diagnostic findings and laparoscopic removal of an exostosis of the os pubis in a horse. STUDY DESIGN: Case report. ANIMAL: One 12-year-old Black Forest draught gelding. METHODS: History included recurrent colic before and during urination and poor performance. Findings at rectal examination included a pointed osseous prominence adjacent to the symphysis of the pecten ossis pubis. Cystoscopy revealed that this prominence caused a protrusion of the bladder wall into the lumen. Standing laparoscopy and laparoscopy under general anesthesia were performed. RESULTS: After a failed attempt at standing laparoscopy, the horse was anesthetized, and the exostosis of the os pubis was removed laparoscopically without complications. No recurrence of clinical signs associated with the exostosis was detected 12 months postoperatively. CONCLUSION: Minimally invasive surgical resection of an exostosis of the os pubis was achieved under general anesthesia with appropriately designed instruments. This treatment alleviated symptoms associated with the exostosis, including potential injury of the urinary bladder wall.


Subject(s)
Exostoses/veterinary , Horse Diseases/surgery , Pubic Bone/surgery , Animals , Exostoses/surgery , Horses , Humans , Male , Pubic Bone/pathology
5.
BMJ Case Rep ; 12(8)2019 Aug 28.
Article in English | MEDLINE | ID: mdl-31466986

ABSTRACT

Kerion is a severe hypersensitivity reaction to fungal infection that is rarely seen in the groin. Frequent shaving of pubic hair and religious conservatism surrounding genital hygiene are common among Bedouin women in the Negev Desert, and may predispose to kerion. This case highlights the clinical course of a 20-year-old Bedouin woman who presented with severe kerion celsi of the pubis and vulva with secondary bacterial infection. The patient was successfully treated with intravenous antibiotics, oral antifungal medication and wet topical dressings. The case outlines the risk factors and treatment for severe kerion celsi of the groin, as well as possible preventive measures that may reduce its incidence.


Subject(s)
Bacterial Infections/drug therapy , Pubic Bone/microbiology , Tinea Capitis/complications , Tinea/complications , Vulva/microbiology , Administration, Intravenous , Administration, Oral , Anti-Bacterial Agents/therapeutic use , Antifungal Agents/therapeutic use , Bacterial Infections/diagnosis , Bacterial Infections/etiology , Female , Groin/microbiology , Groin/pathology , Humans , Pubic Bone/pathology , Tinea/diagnosis , Tinea/drug therapy , Tinea Capitis/diagnosis , Tinea Capitis/drug therapy , Treatment Outcome , Trichophyton/isolation & purification , Vulva/pathology , Young Adult
6.
Intern Med ; 58(17): 2555-2560, 2019 Sep 01.
Article in English | MEDLINE | ID: mdl-31178507

ABSTRACT

A 73-year-old man was referred to our hospital with a persistent fever, anemia, and a mass in the left pubic region. The findings of biopsy evaluations of the mass and a left inguinal lymph node were consistent with Castleman disease (CD) of plasma cell type. His serum interleukin 6 (IL-6) level was remarkably elevated, supporting the diagnosis of CD. However, imaging analyses revealed destruction of the pubic bone by the mass, which was atypical for CD. Therefore, another deeper biopsy was performed, which finally led to the diagnosis of IL-6-producing osteosarcoma. We conclude that clinicians should carefully exclude malignancies prior to making a CD diagnosis.


Subject(s)
Bone Neoplasms/diagnosis , Castleman Disease/diagnosis , Osteosarcoma/diagnosis , Pubic Bone/pathology , Aged , Anemia/etiology , Biopsy , Bone Neoplasms/diagnostic imaging , Bone Neoplasms/pathology , Castleman Disease/pathology , Diagnosis, Differential , Fever/etiology , Humans , Inflammation/pathology , Interleukin-6/blood , Lymph Nodes/pathology , Male , Osteosarcoma/diagnostic imaging , Osteosarcoma/pathology , Plasma Cells/pathology , Pubic Bone/diagnostic imaging
7.
J Biol Regul Homeost Agents ; 33(2 Suppl. 1): 183-186. XIX Congresso Nazionale S.I.C.O.O.P. Societa' Italiana Chirurghi Ortopedici Dell'ospedalita' Privata Accreditata, 2019.
Article in English | MEDLINE | ID: mdl-31172930

ABSTRACT

Pubic osteolysis is a rare pathology characterized by a painful radiographic destructive changes in the pubic rami, pubis or pubic symphysis that often follows a post-traumatic event. The etiology is unclear but it is a benign lesion, frequently misinterpreted as malignant. We report a case of a 54-year-old woman with pubic osteolysis mimicking a malignant lesion, diagnosed after open bone biopsy, conservatively treated without any sequelae and followed-up 10 years after the end of treatment. Although in the majority of the reported cases, a previous trauma has been commonly referred, in our case the patient did not refer to any cause before the onset of clinical symptoms. Knowledge of this entity is important to avoid invasive diagnostic procedures, costly investigations or overtreatment.


Subject(s)
Osteolysis/diagnosis , Pubic Bone/pathology , Bone Neoplasms , Female , Follow-Up Studies , Humans , Middle Aged
8.
Arch Ital Urol Androl ; 91(1): 63-67, 2019 Mar 29.
Article in English | MEDLINE | ID: mdl-30932436

ABSTRACT

Pubic bone osteomyelitis is a rare infectious condition which is characterized by a complex diagnostic and therapeutic workup, due to its various clinical manifestations. Among the many causes of this condition, urinary fistula is the most common in case of previous urological procedures. In order to solve this complication, it is crucial to treat both the fistula and (moreover) the infectious locus arising from it, because treating the fistula alone does not provide any control on the infectious noxa. We present the first case of pubic bone osteomyelitis arising from a urinary fistula after a robotic radical cystectomy with intra corporeal continent neobladder, which has been successfully treated through a multidisciplinary approach.


Subject(s)
Cystectomy/methods , Osteomyelitis/etiology , Urinary Diversion/methods , Urinary Fistula/complications , Aged , Cystectomy/adverse effects , Humans , Male , Osteomyelitis/diagnosis , Osteomyelitis/therapy , Postoperative Complications/pathology , Postoperative Complications/therapy , Pubic Bone/pathology , Robotic Surgical Procedures/methods , Urinary Bladder Neoplasms/surgery , Urinary Fistula/etiology , Urinary Fistula/therapy
9.
Orthopade ; 48(8): 704-707, 2019 Aug.
Article in English | MEDLINE | ID: mdl-30843104

ABSTRACT

Percutaneous osteoplasty (POP) has been proven to relieve pain due to osteolytic metastases by injecting bone cement to stabilize the pathological fracture. Nevertheless, there have been few reports about POP of metastases in the pubis. This article presents a case involving the use of POP to manage a metastasis in the pubis. After POP the patient experienced significant pain relief and improvement in the quality of life.


Subject(s)
Bone Neoplasms , Cementoplasty , Pubic Bone/pathology , Aged , Bone Cements , Female , Humans , Quality of Life , Treatment Outcome
12.
Gynecol Obstet Fertil Senol ; 46(12): 900-912, 2018 12.
Article in French | MEDLINE | ID: mdl-30396762

ABSTRACT

OBJECTIVES: To assess whether pelvic size and shape, spinal curvature, perineal body length and genital hiatus size are associated with the incidence of childbirth pelvic floor trauma. Special situations, such as obesity, ethnicity and hyperlaxity, will also be studied. METHODS: A bibliographic research using Pubmed and Cochrane Library databases was conducted until May 2018. Publications in English and French were selected by initial reading of the abstracts. Randomized trials, meta-analyzes, case-control studies and large cohorts were studied in a privileged way. RESULTS: A pubic arch angle<90° (measured clinically) does not appear to increase the risk of OASIS (Level 3), but appears to be a risk factor for postnatal anal incontinence at short-term, but not at long-term (Level 3). Measurement of pelvic dimensions and the subpubic angle is not recommended to predict OASIS or to choose the mode of delivery for the purpose of protecting the perineum (GradeC). Prenatal measurement of both perineal body (Level 3) and genital hiatus (Level 2) does not predict the incidence of 2nd or 3rd degree OASIS. Therefore, the routine prenatal measurement of the length of the perineal body or the genital hiatus is not recommended for any objective related to perineal protection (Grade C). Levator avulsion, resulting in a widening of the genital hiatus, is potentially a source of long-term pelvic floor dysfunction. Biomechanical models suggest that performing a mediolateral episiotomy and applying the fingers to the posterior perineum at the time of expulsive phase may reduce pelvic floor trauma. Obese women have a longer perineal body (Level 3), and obesity does not seem to increase the risk of OASIS (Level 2). There is no difference between Asian and non-Asian women perineal body (Level 3). No studies have validated that the liberal practice of episiotomy in Asian women reduced the risk of OASIS. It is therefore not recommended to practice an episiotomy for simple ethnic reasons in Asian women (GradeC). Compared to white women, black women do not appear to have an increased risk of OASIS and even appear to have a decreased risk of perineal tears of all stages (Level 2). Ligament hyperlaxity seems to be associated with an increased risk of OASIS (Level 2). CONCLUSIONS: Prenatal assessment of pelvis bone, spine curvature, perineal body and genital hiatus do not allow to predict the incidence of childbirth pelvic floor trauma. Obesity and ethnicity are not risk factors for OASIS.


Subject(s)
Obstetrics/methods , Pelvic Floor/injuries , Perineum/injuries , Case-Control Studies , Delivery, Obstetric/methods , Episiotomy , Ethnicity , Fecal Incontinence/etiology , Female , France , Humans , Lacerations , Obesity/complications , Pelvis/pathology , Perineum/pathology , Pregnancy , Pregnancy Complications , Pubic Bone/pathology , Risk Factors
13.
J Am Acad Orthop Surg ; 26(11): e246-e248, 2018 Jun 01.
Article in English | MEDLINE | ID: mdl-29697500

ABSTRACT

The hip is a common location for heterotopic ossification after surgical trauma, blunt trauma, or muscle injury. However, the region around the pubic rami is an unusual location for heterotopic bone formation. Here, we present a case of a young, active man in the Armed Forces Reserve with a large heterotopic bone involving the left inferior pubic ramus who underwent surgical excision through an unusual approach via the perineum. The patient had notable pain relief postoperatively and returned to his active duties 1 month after surgery without discomfort or functional limitation.


Subject(s)
Ossification, Heterotopic/pathology , Pubic Bone/pathology , Adult , Humans , Male , Ossification, Heterotopic/surgery , Perineum/surgery , Pubic Bone/surgery , Treatment Outcome
15.
BMC Cancer ; 17(1): 454, 2017 Jun 29.
Article in English | MEDLINE | ID: mdl-28662644

ABSTRACT

BACKGROUND: The pathological and oncological outcomes of retro-pubic radical prostatectomy (RRP) and robot-assisted radical prostatectomy (RARP) have not been sufficiently investigated. METHODS: Treatment-naïve patients with localized prostate cancer (PC) (n = 908; RRP, n = 490; and RARP, n = 418) were enrolled in the study. The clinicopathological outcomes, rate and localization of the positive surgical margin (PSM), localization of PSM, and biochemical recurrence (BCR)-free survival groups were compared between RRP and RARP. RESULTS: The median patient age and serum PSA level (ng/mL) at diagnosis were 67 years and 7.9 ng/ml, respectively, for RRP, and 67 years and 7.6 ng/ml, respectively, for RARP. The overall PSM rate with RARP was 21%, which was 11% for pT2a, 12% for pT2b, 9.8% for pT2c, 43% for pT3a, 55% for pT3b, and 0% for pT4. The overall PSM rate with RRP was 44%, which was 12% for pT2a, 18% for pT2b, 43% for pT2c, 78% for pT3a, 50% for pT3b, and 40% for pT4. The PSM rate was significantly lower for RARP in men with pT2c and pT3a (p < 0.0001 for both). Multivariate analysis showed that RARP reduced the risk of BCR (hazard ratio; 0.6, p = 0.009). CONCLUSIONS: RARP versus RRP is associated with an improved PSM rate and BCR. To examine the cancer-specific survival, further investigations are needed.


Subject(s)
Neoplasm Recurrence, Local/surgery , Prostatectomy , Prostatic Neoplasms/surgery , Pubic Bone/surgery , Robotics , Aged , Aged, 80 and over , Follow-Up Studies , Humans , Laparoscopy , Male , Middle Aged , Neoplasm Recurrence, Local/pathology , Prostatic Neoplasms/pathology , Pubic Bone/pathology , Retrospective Studies , Survival Rate , Treatment Outcome
16.
Magn Reson Med Sci ; 16(4): 317-324, 2017 Oct 10.
Article in English | MEDLINE | ID: mdl-28190854

ABSTRACT

PURPOSE: Our aims were to determine the feasibility of diffusion-weighted magnetic resonance imaging (DWI) in the detection of bone marrow edema (BME) and explore the apparent diffusion coefficient (ADC) alterations in patients with osteitis pubis (OP). MATERIALS AND METHODS: 42 consecutive patients clinically suspected to have athletic pubalgia and 31 control subjects were enrolled in the study. All subjects underwent diagnostic focused magnetic resonance imaging (MRI) and DWI at b values of 0 and 600 s/mm2. Two radiologists reviewed the images for the presence of active OP. The presence of subchondral BME and contrast enhancement were considered to indicate active OP. ADC values were measured from public bodies of both groups. DWI results were correlated with routine MRI findings. Receiver-operating-characteristic curves were formed. Cut-off values for ADC, sensitivity and specificity values were measured. RESULTS: 36/42 (85%) of the cases had BME/enhancement on routine MRIs and identified as active OP. ADC measurements of the patients were greater than the controls (P < 0.05). For the optimal cut-off values DWI showed sensitivity and specificity values of 97.3%, and 90.3%, for the right, and 97.1%, and 96.7% for the left side, respectively (Area under the curve 0.965 and 0.973). Intra-and inter-rater reliability for readers were substantial-perfect for all sessions. CONCLUSION: DWI is fast, accurate, and highly reproducible technique for the detection of BME in patients with active OP. It allows distinct bone marrow contrast without the use of gadolinium contrast, increases visual perception of active lesions, gives objective information by quantifying the diffusion coefficients, thus increase diagnostic confidence. We suggest the use of DWI as a cost-effective adjunctive tool for the diagnosis of active OP particularly in early cases and inconclusive diagnostic MRI. Future studies are necessary to determine the utility of DWI to evaluate severity of the disease and treatment response before returning athletes to play.


Subject(s)
Athletic Injuries/diagnostic imaging , Bone Marrow/diagnostic imaging , Diffusion Magnetic Resonance Imaging/methods , Edema/diagnosis , Osteitis/diagnostic imaging , Osteitis/pathology , Pubic Bone/diagnostic imaging , Adult , Aged , Athletic Injuries/pathology , Bone Marrow/pathology , Edema/pathology , Female , Humans , Male , Middle Aged , Prospective Studies , Pubic Bone/pathology , ROC Curve , Reproducibility of Results , Sensitivity and Specificity , Young Adult
17.
Knee Surg Sports Traumatol Arthrosc ; 25(6): 1958-1966, 2017 Jun.
Article in English | MEDLINE | ID: mdl-28093636

ABSTRACT

PURPOSE: The incidence of groin pain in athletes is steadily increasing. Symptomatic pubic overload with groin pain and aseptic osteitis pubis represent well-known and frequently misdiagnosed overuse injuries in athletes. This study investigated the benefits of standardised non-surgical treatment for swift return-to-football. METHODS: In a prospective double-blinded controlled study, 143 amateur football players with groin pain as well as radiological signs and clinical symptoms of pubic overload were analysed for 1 year. Two randomised study groups participated in an intensive physical rehabilitation programme, either with or without shock wave therapy. The control group did not participate in any standardised rehabilitation programme but only stopped participating in sports activity. Follow-up examinations took place 1, 3 months and 1 year after the beginning of therapy. Endpoints were visual analogue scale (VAS), functional tests, the time of return-to-football, recurrent complaints and changes in the MR image. RESULTS: Forty-four football players with groin pain and aseptic osteitis pubis were randomised into two study groups; 26 received shock wave therapy, 18 did not. Clinical examination showed pubic overload as a multi-located disease. Players receiving shock wave therapy showed earlier pain relief in the VAS (p < 0.001) and returned to football significantly earlier (p = 0.048) than players without this therapy. Forty-two of 44 players of both study groups returned to football within 4 months after the beginning of therapy and had no recurrent groin pain within 1 year after trauma. Fifty-one players of the control group returned to football after 240 days (p < 0.001), of whom 26 (51%) experienced recurrent groin pain. Follow-up MRI scans did not show any effect of shock wave therapy. CONCLUSION: Non-surgical therapy is successful in treating pubic overload and osteitis pubis in athletes. Shock wave therapy as a local treatment significantly reduced pain, thus enabling return-to-football within 3 months after trauma. Early and correct diagnosis is essential for successful intensive physiotherapy. LEVEL OF EVIDENCE: I.


Subject(s)
Cumulative Trauma Disorders/therapy , Extracorporeal Shockwave Therapy , Groin/injuries , Pain Management , Physical Therapy Modalities , Soccer/injuries , Cumulative Trauma Disorders/complications , Cumulative Trauma Disorders/diagnostic imaging , Double-Blind Method , Groin/diagnostic imaging , Humans , Magnetic Resonance Imaging , Male , Osteitis/diagnostic imaging , Osteitis/etiology , Pain/etiology , Prospective Studies , Pubic Bone/pathology , Radiography , Young Adult
18.
Surg Technol Int ; 31: 365-373, 2017 Dec 12.
Article in English | MEDLINE | ID: mdl-29316596

ABSTRACT

V an Neck-Odelberg disease (VND) is a benign skeletal overgrowth of the ischiopubic synchondrosis (IPS) in prepubescent patients. There is a paucity of long-term follow-up data and reviews on management decision-making. We report on a 15-year-old female, with a history of sickle-cell disease (HbSS), presenting with unilateral groin pain. Patient's physical examination, radiographs, and a literature-review determined a diagnosis of VND. Conservative treatment was issued. Clinical symptoms resolved at three months, followed by complete lesion resolution at three years. Additionally, a search of Medline (PubMed), EMBASE, and OVID databases was performed. Reports including VND/IPS diagnosis, treatment, or follow-up decisions were identified. Systematic-review found 17 relevant articles, reporting on 29 patients. Patients presented with groin (51.7%) or buttock (20.7%) pain, and were diagnosed using X-ray (n=23) and magnetic resonance imaging (MRI) (n=17). Twenty-five patients were treated conservatively, with two (8.0%) reports of surgical intervention. Average follow-up was 6.25 months. Our case report and systematic-review support conservative treatment for VND.


Subject(s)
Ischium , Osteochondrosis , Pubic Bone , Adolescent , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Conservative Treatment , Female , Humans , Ischium/diagnostic imaging , Ischium/pathology , Ischium/physiopathology , Osteochondrosis/diagnostic imaging , Osteochondrosis/pathology , Osteochondrosis/physiopathology , Osteochondrosis/therapy , Pubic Bone/diagnostic imaging , Pubic Bone/pathology , Pubic Bone/physiopathology , Radiography , Weight-Bearing
20.
Orv Hetil ; 157(21): 836-9, 2016 May 22.
Article in Hungarian | MEDLINE | ID: mdl-27177791

ABSTRACT

Osteochondritis ischiopubica or van Neck-Odelberg disease is characterized by atypical ossification of the ischiopubic synchondrosis. Clinical symptoms are usually pain, limping and limited range of motion of the hip joint. Radiologic images may be confused with the possibility of fracture, tumor or inflammation. In some cases it may be difficult to set up the accurate diagnosis, and during the diagnostic process it is essential that van Neck-Odelberg disease should be considered. In this paper the authors draw attention to this rare disorder and they present the history of two patients who posed diagnostic difficulties.


Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Bed Rest , Bone Regeneration , Osteochondrosis/diagnosis , Osteochondrosis/therapy , Pain/etiology , Adolescent , Biomarkers/blood , Bone Remodeling , Child , Diagnosis, Differential , Female , Fibrosis/diagnosis , Humans , Ischium/pathology , Ischium/physiopathology , Magnetic Resonance Imaging , Male , Necrosis/diagnosis , Osteochondritis/diagnosis , Osteochondritis/therapy , Osteochondrosis/complications , Osteochondrosis/pathology , Osteochondrosis/physiopathology , Pubic Bone/pathology , Pubic Bone/physiopathology , Rare Diseases/diagnosis , Rare Diseases/therapy , Tomography, X-Ray Computed
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