RESUMO
Cyclosporine prolonged the survival of ectopic small bowel allografts in a canine model. A 9-fold increase in mean survival as compared with controls was obtained. Addition of prednisone to cyclosporine did not result in further graft prolongation, but improved the gross and histological appearance of the allograft. Monitoring the motility and histology of the allograft appears to be useful in predicting approaching rejection. Xylose absorption was not helpful in this regard. A new technique for measuring fat absorption in the transplant is described. Following allografting, fat absorption is resumed by 14 days posttransplantation.
Assuntos
Ciclosporinas/uso terapêutico , Intestino Delgado/transplante , Animais , Cães , Feminino , Motilidade Gastrointestinal , Rejeição de Enxerto/efeitos dos fármacos , Absorção Intestinal , Intestino Delgado/patologia , Masculino , Ácido Oleico , Ácidos Oleicos/metabolismo , Xilose/metabolismoRESUMO
Two groups of puppies were studied regarding survival of the heart and the animal after epinephrine induced shock. All puppies in the control study died. In each of the eight puppies in the experimental group, the heart was removed and transplanted orthotopically into a healthy recipient. Six of the eight recipients died within hours, and the two which survived 14 days exhibited extensive cardiac structural changes at autopsy. The failure of recipients of hearts from these spinephrine-shock puppies to survive was in sharp contrast to the almost uniform survival of animals receiving orthotopic heart transplants from dogs subjected to irreversible hemorrhagic or endotoxin shock. This diference was due to the fact that the high levels of epinephrine infused were found to have produced extensive structural damage in the donor heart.