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1.
PLoS One ; 19(9): e0310081, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-39298392

RESUMO

BACKGROUND: Kidney function assessment is crucial in critical illness patients and is required before administering renally excreted medication, especially antibiotics and antiepileptics. Conventional clinical practice often focuses on renal impairment with low creatinine clearance (CrCl) and overlooks the augmented renal clearance (ARC), which is defined by (CrCl) more than 130 ml/min. This typical demonstration neglects individuals who experience hyperfunctioning kidneys. Among critically ill patients, the prevalence of (ARC) is approximately 20% to 65% of cases. This study aims to evaluate physicians' and clinical pharmacists' knowledge about ARC-associated risk factors, antibiotic regimen modification in ARC patients, and attitudes towards ARC workshops and guidelines in Al-Ain, UAE. METHODS: A cross-sectional, online self-administered survey-based study was designed to achieve this study's aim. The questionnaire was constructed on profound literature analysis, validated, and piloted. The survey was emailed to physicians and pharmacists working in two hospitals, private and governmental, and distributed through different social media platforms over three months, December 2022-February 2023. RESULTS: Of the 92 complete responses (32 clinical pharmacists, 60 physicians), 57 (61.9%), were aware of ARC, but 72 (78%) demonstrated poor knowledge overall. Clinical pharmacists had a higher mean rank of knowledge than the physician's group. Meanwhile, 70 (76.1%) participants were unaware of the eGFR threshold to determine ARC. There is a noticeable positive attitude toward seeking more information about antibiotic dose adjustment in ARC patients at 85 (92%) of the respondents. Remarkably, only 28 (30.4%) were directly involved with ARC patients' treatment plans. CONCLUSION: In conclusion, clinical pharmacists showed better knowledge than physicians. However, overall, the participating healthcare providers lacked knowledge about ARC, so a reliable source of information regarding ARC should be utilized. Future research could explore the implementation of professional development workshops for healthcare providers and national guidelines and then assess their impact on patient outcomes.


Assuntos
Conhecimentos, Atitudes e Prática em Saúde , Farmacêuticos , Médicos , Humanos , Estudos Transversais , Masculino , Feminino , Médicos/psicologia , Adulto , Inquéritos e Questionários , Emirados Árabes Unidos , Pessoa de Meia-Idade , Rim/fisiopatologia , Rim/metabolismo , Atitude do Pessoal de Saúde , Testes de Função Renal
2.
Discov Ment Health ; 4(1): 28, 2024 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-39145898

RESUMO

BACKGROUND: Tiredness, poor concentration, disturbed sleep and poor appetite can all be caused by depression, which is a common mental disorder and a leading cause of disability worldwide. This study aimed to assess the prevalence of major depressive disorder, suicidal ideation, and risk factors in Sudanese children and adolescents during the Sudanese army conflict. METHODS: A descriptive cross-sectional community-based study was carried out among Sudanese children between 11 and 17 years old who living in Sudan at the start of the conflict by using a self-administered questionnaire under the guidance of parents, if necessary. The questionnaire was adapted from the Patients Health Questionnaire-9 (PHQ-9) checklist for the assessment of major depression disorder symptoms according to the Diagnostic and Statistical Manual Edition 5th Edition (DSM-5). The questionnaire was translated into Arabic by two expert translators, and its validity and reliability were confirmed. Data analysis was performed using Statistical Package for the Social Sciences version 25 software, and descriptive analysis and any appropriate statistical tests were performed. RESULTS: Among the 963 participants, the mean age was 15.18 ± 2.1 years, 65.5% were female, and 67.7% had major depressive disorder. There was a significant relationship between MDD score, age, sex, current residency status, and traumatic event exposure, with P values less than 0.001 for all variables. CONCLUSION: Major depressive disorder was highly prevalent among Sudanese children and adolescents included in the present study. Additionally, suicidal ideation, which requires immediate intervention, was reported to be very high. The findings will help the government to provide proper mental health interventions for affected people.

3.
J Fluoresc ; 2024 Jul 03.
Artigo em Inglês | MEDLINE | ID: mdl-38958904

RESUMO

A new eco-friendly sensor, 3-((6-((4-chlorobenzylidene)amino)pyridin-2-yl)imino)indolin-2-one (CBAPI) was synthesized and well characterized. The CBAPI sensor was employed for detecting Zn2+ and Fe3+ ions. It exhibited a low limit of detection at pH 6.0, with values of 2.90, for Zn2+ and 3.59 nmol L-1 for Fe3+ ions. The sensor demonstrated high selectivity over other interfering cations. Additionally, the high binding constants reflect the great affinity of sensor towards Zn2+ and Fe3+ ions. To further validate its quantification ability for Zn2+ ions, the synthesized CBAPI sensor was used to determine Zn levels in human hair samples, and the results were confirmed using atomic absorption spectroscopy (AAS). The AGREE metric tool was used to assess the method's environmental impact and practical applicability. These positive outcomes indicated that the new method for detecting Zn2+ and Fe3+ ions is environmentally friendly and safe for humans. The developed CBAPI sensor represents a potential development in metal ion detection, combining sensitivity, selectivity, and rapidity.

4.
Hum Genomics ; 17(1): 63, 2023 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-37454085

RESUMO

INTRODUCTION: The adoption and implementation of genomic medicine and pharmacogenomics (PGx) in healthcare systems have been very slow and limited worldwide. Major barriers to knowledge translation into clinical practice lie in the level of literacy of the public of genetics and genomics. The aim of this study was to assess the knowledge, attitudes, and perceptions of the United Arab Emirates (UAE) multi-ethnic communities toward genomic medicine and genetic testing. METHOD: A cross-sectional study using validated questionnaires was distributed to the participants. Descriptive statistics were performed, and multivariable logistic regression models were used to identify factors associated with knowledge of genomics. RESULTS: 757 individuals completed the survey. Only 7% of the participants had a good knowledge level in genetics and genomics (95% CI 5.3-9.0%). However, 76.9% of the participants were willing to take a genetic test if their relatives had a genetic disease. In addition, the majority indicated that they would disclose their genetic test results to their spouses (61.5%) and siblings (53.4%). CONCLUSIONS: This study sets the stage for the stakeholders to plan health promotion and educational campaigns to improve the genomic literacy of the community of the UAE as part of their efforts for implementing precision and personalized medicine in the country.


Assuntos
Medicina Genômica , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Emirados Árabes Unidos/epidemiologia , Estudos Transversais , Inquéritos e Questionários
5.
Asian Pac J Cancer Prev ; 24(2): 479-487, 2023 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-36853296

RESUMO

Breast cancer is considered the most dangerous cancer for women, driving the highest number of mortalities in women worldwide. According to the WHO 2020 report, breast cancer showed the highest five-year prevalence in the UAE, among other cancers. This research assessed breast cancer awareness, potential risk factors, screening approaches and practices, barriers to screening, and attitudes toward seeking medical help among UAE women. A cross-sectional community-based study was conducted through a web-based validated questionnaire. Data analysis was carried out using IBM SPSS version 27. The questionnaire was sent through social media platforms. The eligible completed were 616 responses. This study showed a prevalence of breast cancer of 3.1% among the study population. Regarding Breast cancer knowledge, most of the participants, 65.8% had moderate knowledge, 19% had poor knowledge, and only 7.6% had good knowledge. Breast cancer screening methods were the most recognized section at 76%, followed by knowledge of symptoms and while the least known section was the BC risk factors. Twenty-five percent of respondents had at least one breast cancer symptom. About 37.1% of women aged more than 40 years had never undergone mammography. In potential, most participants and 81.7% were having more than five of the BC risk factors had adequate knowledge about breast cancer with relatively higher knowledge scores for screening methods and symptoms. Participants who received information from healthcare providers or attended awareness events had a higher knowledge score. In contrast, insufficient mammography screening had been revealed. At the same time, potential risk evaluation revealed a high percentage of participants suffering from many potential risk factors.


Assuntos
Neoplasias da Mama , Detecção Precoce de Câncer , Humanos , Feminino , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/epidemiologia , Estudos Transversais , Mamografia , Fatores de Risco
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