Investigation of melamine and cyanuric acid concentration in several brands of liquid milk and its non-carcinogenic risk assessment in adults and infants.

In this study, the melamine and cyanuric acid concentration of widely used milk brands and the probability of non-carcinogenic risk of the brands for adults and infants were investigated. These values were 1.37 mg/L, 1.10 mg/L, and 1.09 mg/L, which corresponded to creamy sterilized sample, high-fat (creamy) pasteurized sample, and low-fat (less-creamy) pasteurized sample, respectively. Similarly, the highest amount of cyanuric acid occurred in brand A with the values of 0.79 mg/L, 0.65 mg/L, and 0.64 mg/L, which was reported in the same samples mentioned for melamine. The HQ (Hazard Quotient) of melamine in the brands of A, B, C and D for adults was 0.0025, 0.0011, 0.0006 and 0.0008 respectively. These values for infants were reported as 2.2280, 0.9444, 0.5714 and 0.6714 respectively. The risk probability of melamine for adults was less than 1. However, the HQ in brand A for infants was greater than 1 (2.380), which indicate the high probability of non-carcinogenic risk. Furthermore, the HI (Hazard Index) values of the brands of A, B, C and D for infants were 2.7913, 1.1737, 0.7067 and 0.838, respectively. The simultaneous melamine and cyanuric acid in the brands A and B in for infants increase the non-carcinogenic risk probability by approximately 2.8 and 1.2 times, respectively. The results revealed that the melamine and cyanuric acid concentrations in creamy milk samples (0.5%) were higher than in less-creamy milk samples (2.5%). Moreover, the amount of the compounds in sterilized milk samples was higher than pasteurized. In this study, a conversion factor (0.7) was proposed in order to find out the concentration of cyanuric acid in milk sample with the amount of melamine is known but the cyanuric acid concentration is unknown.

Determination of melamine contamination in chocolates containing powdered milk by high-performance liquid chromatography (HPLC).

Melamine is widely being reported as a food adulterant. Although its toxicity is currently recognized, melamine adulterations of dairy products are ongoing to apparently increase the amount of protein. The study was conducted to investigate the determination of melamine amounts in chocolates containing powdered milk. In this study, 60 samples of chocolates containing powdered milk, both imported and domestic brands, were collected. The samples were prepared by solid phase extraction (SPE) and analyzed using high-performance liquid chromatography (HPLC). According to the results, melamine was found in about 94% of imported samples and about 77% of Iranian samples. Melamine concentration in imported samples ranged from 0.032 to 2.692 mg/kg, while in Iranian ones it ranged from 0.013 to 2.600 mg/kg. The mean melamine concentrations of foreign and Iranian samples were 0.685 ± 0.68 and 0.456 ± 0.73 mg/kg, respectively. Moreover, the limit of detection (LOD) and limit of quantification (LOQ) values of melamine were 0.017 and 0.052 µg/ml, respectively. The recovery rate (R%) at fortified levels of 1-2 mg/kg was found to be 89.20-95.69% with an RSD (Relative Standard Deviation) of 1.8-2.7%. Based on the study results, melamine was present in 85% of all samples and the melamine level in one Iranian brand and one imported brand was higher than the Codex Organization standard. However, the consumption of chocolates containing these low levels of melamine does not constitute a health risk for consumers.

Health consequences of shift-work: the case of iranian hospital security personnel.

BACKGROUND: Shift-work, which is an ergonomics issue in workplaces, can negatively affect workers. The security personnel of medical centers in Iran have multiple responsibilities and consequently are exposed to such unwanted situations as observing patients, disputing with patient's attendants, unwanted shift schedules, and being away from family for long periods. OBJECTIVE: This study assessed health problems of Iranian hospital security personnel (shift-worker personnel) using the Survey of Shift-workers (SOS) questionnaire (Persian version). METHODS: This cross-sectional study was conducted in seven medical centers (4 hospitals and 3 clinics). A total of 416 workers were surveyed: shift-workers (exposed group) (n=209) and non-shift-workers (unexposed group) (n=207). RESULTS: The prevalence of adverse health effects was higher in shift-workers than day-workers. The level of education and mean Body Mass Index (BMI) in shift-workers were significantly higher compared with day-workers. The prevalence of gastrointestinal disorders, cardiovascular and psychological problems were also significantly higher in shift-workers compared with day-workers. CONCLUSIONS: Overall, the prevalence of health problems among the security personnel of medical centers was high. Hence, it is recommended that personnel be put under periodic monitoring and receive medical counseling and treatment if there is any disorder.