RESUMO
A 62-year-old male was diagnosed as AFP-producing gastric cancer with lymph node metastases and multiple liver metastases. He was treated with S-1 and CDDP combination chemotherapy. At the end of the first course, both primary and metastatic lesions were remarkably decreased in size, and the serum AFP level was also decreased. The chemotherapy was effective against the cancer and led to a partial response (PR) according to the RECIST guideline. Following the nine months of PR, the primary lesion which had once nearly disappeared, emerged again. Because distant lymph node metastases and liver metastases were considered to have disappeared, distal gastrectomy with D2 lymphadenectomy was performed. The patient received S-1 monotherapy for 6 months after the operation. At present the patient has achieved progression-free survival for 1 year and 3 months after the operation. Though AFP-producing gastric cancer is known for its poor prognosis, combination treatment such as operation or hepatic arterial infusion chemotherapy may improve the prognosis in patients with advanced AFP-producing gastric cancer when systemic chemotherapy is effective.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Cisplatino/uso terapêutico , Ácido Oxônico/uso terapêutico , Neoplasias Gástricas/tratamento farmacológico , Tegafur/uso terapêutico , alfa-Fetoproteínas/biossíntese , Cisplatino/administração & dosagem , Combinação de Medicamentos , Humanos , Masculino , Pessoa de Meia-Idade , Ácido Oxônico/administração & dosagem , Neoplasias Gástricas/diagnóstico por imagem , Neoplasias Gástricas/metabolismo , Neoplasias Gástricas/cirurgia , Tegafur/administração & dosagem , Tomografia Computadorizada por Raios XRESUMO
In this study, we have developed a meander-shaped dynamic microfluidic technology that allows us to pair two different types of microbeads in a trapping site. The dynamic microfluidic technology comprises implemented modifications of a conventional dynamic microarray design such as: (i) the combination of a meander-shaped by-pass channel and a trapping channel with a hydrodynamic trapping site and (ii) line-symmetrical formation of the by-pass and trapping channels. Using these modifications, we have successfully trapped different types of sample in one trapping site, and constructed an array of paired beads of different type such as polystyrene beads or hydrogel beads made of agarose, collagen or alginate. We found that this meander-shaped dynamic microfluidic technology is applicable for the observation of interactions between the paired beads such as molecular diffusion.